ITPR3_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ITPR3_RAT
• UniProt AC: Q63269
• Protein Name: Inositol 1,4,5-trisphosphate receptor type 3
• Gene Name: Itpr3
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 2670
• Subcellular Localization: Endoplasmic reticulum membrane; Multi-pass membrane protein.
• Protein Description: Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium..
• Protein Sequence: MNEMSSFLHIGDIVSLYAEGSVNGFISTLGLVDDRCVVEPAAGDLDNPPKKFRDCLFKVCPMNRYSAQKQYWKAKQTKQDKEKIADVVLLQKLQHAAQMEQKQNDTENKKVHGDVVKYGSVIQLLHMKSNKYLTVNKRLPALLEKNAMRVTLDATGNEGSWLFIQPFWKLRSNGDNVVVGDKVILNPVNAGQPLHASNYELSDNVGCKEVNSVNCNTSWKINLFMQFRDHLEEVLKGGDVVRLFHAEQEKFLTCDEYRGKLQVFLRTTLRQSATSATSSNALWEVEVVHHDPCRGGAGHWNGLYRFKHLATGNYLAAEENPSYKGDVSDPKAAGPGAQSRTGRRNAGEKIKYRLVAVPHGNDIASLFELDPTTLQKTDSFVPRNSYVRLRHLCTNTWIQSTNAPIDVEEERPIRLMLGTCPTKEDKEAFAIVSVPVSEIRDLDFANDASSMLASAVEKLNEGFISQNDRRFVIQLLEDLVFFVSDVPNNGQNVLDIMVTKPNRERQKLMRDENILKQIFGILKAPFRDKGGEGPLVRLEELSDQKNAPYQYMFRLCYRVLRHSQEDYRKNQEHIAKQFGMMQSQIGYDILAEDTITALLHNNRKLLEKHITKTEVETFVSLVRKNREPRFLDYLSDLCVSNRIAIPVTQELICKCVLDPKNSDILIQTELRPVKEMAQSHEYLSIEYSEEEVWLTWTDRNNEHHEKSVRQLAQEARAGNAHDENVLSYYRYQLKLFARMCLDRQYLAIDEISKQLGVELLFLCMADEMLPFDLRASFCHLMLHVHVDRDPQELVTPVKFARLWTEIPTAITIKDYDSNLNASRDDKKNKFASTMEFVEDYLNNVVGEAVPFANDEKNILTFEVVSLAHNLIYFGFYSFSELLRLTRTLLGIIDCIQAPAAVLQAYEEPGGKNVRRSIQGVGHMMSTMVLSRKQSVFGASSLPTGVGVPEQLDRSKFEDNEHTVVMETKLKILEILQFILNVRLDYRISYLLSVFKKEFVEVFPMQDSGADGTAPAFDSSTANMNLDRIGEQAEAMFGVGKTSSMLEVDDEGGRMFLRVLLHLTMHDYPPLVSGALQLLFKHFSQRQEAMHTFKQVQLLISAQDVENYKVIKSELDRLRTMVEKSELWVDKKGSVKGEEGEAGASKDKKERPSDEEGFLQPHGEKSSENYQIVKGILERLNKMCGVGEQMRKKQQRLLKNMDAHKVMLDLLQIPYDKNDNKMMEILRYTHQFLQKFCAGNPGNQALLHKHLQLFLTPGLLEAETMQHIFLNNYQLCSEISEPVLQHFVHCWPTHGRHVQYLDFLHTVIKAEGKYVKKCQDMIMTELTNAGDDVVVFYNDKASLAHLLDMMKAARDGVEDHSPLMYHISLVDLLAACAEGKNVYTEIKCTSLLPLEDVVSVVTHEDCITEVKMAYVNFVNHCYVDTEVEMKEIYTSNHIWTLFENFTLDMALVCNKREKRLSDPTLEKYVLTVVLDTISAFFSSPFSENSTSLQTHQTIVVQLLQSTTRLLECPWLQQQHKGSVEACVRTLAMVAKSRAILLPMDLDAHMSALLSSGGSCSAAAQRSAANYKTATRTFPRVIPTANQWDYKNIIEKLQDIITALEERLKPLVQAELSVLVDMLHWPELLFLEGSEAYQRCESGGFLSKLIRHTKGLMESEEKLCVKVLRTLQQMLQKKSKYGDRGNQLRKMLLQNYLQNRKSGPRGELTDPTGSGVDQDWSAIAATQCRLDKEGATKLVCDLITSTKNEKIFQESIGLAIRLLDGGNTEIQKSFYNLMTSDKKSERFFKVLHDRMKRAQQETKSTVAVNMSDLGSQPREDREPADPTTKGRVSSFSMPSSSRYSLGPGLHRGHDVSERAQNNEMGTSVLIMRPILRFLQLLCENHNRDLQNFLRCQNNKTNYNLVCETLQFLDIMCGSTTGGLGLLGLYINEDNVGLVIQTLETLTEYCQGPCHENQTCIVTHESNGIDIITALILNDISPLCKYRMDLVLQLKDNASKLLLALMESRHDSENAERILISLRPQELVDVIKKAYLQEEERENSEVSPREVGHNIYILALQLSRHNKQLQHLLKPVKRIQEEEAEGISSMLSLNNKQLSQMLKSSAPAQEEEEDPLAYYENHTSQIEIVRQDRSMEQIVFPVPAICQFLTEETKHRLFTTTEQDEQGSKVSDFFDQSSFLHNEMEWQRRLRSMPLIYWFSRRMTLWGSISFNLAVFINIIIAFFYPYVEGASTGVLGSPLISLLFWILICFSIAALFTKHYSVRPLIVALVLRSIYYLGIGPTLNILGALNLTNKIVFVVSFVGNRGTFIRGYKAMVMDMEFLYHVGYILTSVLGLFAHELFYSILLFDLIYREETLFNVIKSVTRNGRSILLTALLALILVYLFSIVGFLFLKDDFILEVDRLPGNHSRASTLGMPHGAATFMGTCSGDKMDCVSEVSVPEILEEDEELDSTERACDTLLMCIVTVMNHGLRNGGGVGDILRKPSKDESLFPARVVYDLLFFFIVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVSFEEHIKLEHNMWNYLYFIVLVRVKNKTDYTGPESYVAQMIKNKNLDWFPRMRAMSLVSGEGEGEQNEIRILQEKLGSTMKLVSHLTAQLNELKEQMTEQRKRRQRLGFVDVQNCMSR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
352	Nitration	NAGEKIKYRLVAVPH CCCCCCEEEEEEECC	16.80	18165258
352	Nitrated tyrosine	NAGEKIKYRLVAVPH CCCCCCEEEEEEECC	16.80	-
465	Phosphorylation	KLNEGFISQNDRRFV HHHHCCCCCCCHHHH	22.22	28432305
916	Phosphorylation	GGKNVRRSIQGVGHM CCHHHHHHHHHHHHH	14.54	28432305
934	Phosphorylation	MVLSRKQSVFGASSL HHHCCCCCCCCCCCC	23.58	28826663
939	Phosphorylation	KQSVFGASSLPTGVG CCCCCCCCCCCCCCC	32.55	23984901
940	Phosphorylation	QSVFGASSLPTGVGV CCCCCCCCCCCCCCC	37.52	30181290
1111	Acetylation	VENYKVIKSELDRLR HHCHHHHHHHHHHHH	40.65	22902405
1152	Phosphorylation	KDKKERPSDEEGFLQ CCCCCCCCCCCCCCC	64.97	-
1214	Phosphorylation	LDLLQIPYDKNDNKM HHHHCCCCCCCCCHH	40.97	23800682
1730	Acetylation	ATQCRLDKEGATKLV HHHCCCCCCCCCHHH	63.74	22902405
1787	Acetylation	KKSERFFKVLHDRMK HHHHHHHHHHHHHHH	40.97	22902405
1813	Phosphorylation	VNMSDLGSQPREDRE ECHHHCCCCCCCCCC	44.29	-
1831	Phosphorylation	PTTKGRVSSFSMPSS CCCCCCCCCCCCCCC	25.06	17683130
1832	Phosphorylation	TTKGRVSSFSMPSSS CCCCCCCCCCCCCCC	20.62	17683130
1834	Phosphorylation	KGRVSSFSMPSSSRY CCCCCCCCCCCCCCC	31.56	23984901
1838	Phosphorylation	SSFSMPSSSRYSLGP CCCCCCCCCCCCCCC	16.99	17683130
1839	Phosphorylation	SFSMPSSSRYSLGPG CCCCCCCCCCCCCCC	39.31	17683130
1841	Phosphorylation	SMPSSSRYSLGPGLH CCCCCCCCCCCCCCC	15.36	28432305
1842	Phosphorylation	MPSSSRYSLGPGLHR CCCCCCCCCCCCCCC	26.24	28432305
2089	Phosphorylation	EGISSMLSLNNKQLS CCHHHHHHCCHHHHH	22.02	22108457
2608	Phosphorylation	FPRMRAMSLVSGEGE HHHHHHHHCCCCCCC	25.32	28432305
2669	Phosphorylation	VDVQNCMSR------ CCHHHHCCC------	36.72	22108457

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
916	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
934	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
1832	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ITPR3_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ITPR3_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBC_RAT	Ubc	physical	10191279
UBC_RAT	Ubc	physical	21071436

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.