ITIH4_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ITIH4_MOUSE
• UniProt AC: A6X935
• Protein Name: Inter alpha-trypsin inhibitor, heavy chain 4
• Gene Name: Itih4
• Organism: Mus musculus (Mouse).
• Sequence Length: 942
• Subcellular Localization: Secreted.
• Protein Description: Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in liver development or regeneration..
• Protein Sequence: MKSPAPAHMWNLVLFLPSLLAVLPTTTAEKNGIDIYSLTVDSRVSSRFAHTVVTSRVVNRADAVQEATFQVELPRKAFITNFSMIIDGVTYPGVVKEKAEAQKQYSAAVGRGESAGIVKTTGRQTEKFEVSVNVAPGSKITFELIYQELLQRRLGMYELLLKVRPQQLVKHLQMDIYIFEPQGISILETESTFMTPELANALTTSQNKTKAHIRFKPTLSQQQKSQSEQDTVLNGDFIVRYDVNRSDSGGSIQIEEGYFVHHFAPENLPTMSKNVIFVIDKSGSMSGKKIQQTREALVKILKDLSPQDQFNLIEFSGEANQWKQSLVQATEENLNKAVNYASRIRAHGGTNINNAVLLAVELLDRSNQAELLPSKSVSLIILLTDGDPTVGETNPTIIQNNVREAINGQYSLFCLGFGFDVNYPFLEKMALDNGGLARRIYEDSDSALQLQDFYHEVANPLLSSVAFEYPSDAVEEVTRYKFQHHFKGSEMVVAGKLQDQGPDVLLAKVSGQMHMQNITFQTEASVAQQEKEFKSPKYIFHNFMERLWALLTIQQQLEQRISASGAELEALEAQVLNLSLKYNFVTPLTHMVVTKPEGQEQFQVAEKPVEVGDGMQRLPLAAQAHPFRPPVRGSKLMTVLKGSRSQIPRLGDAVRASRQYIPPGFPGPPGPPGFPAPPGPPGFPAPPGPPLASGSDFSLQPSYERMLSLPSVAAQYPADPHLVVTEKSKESTIPEESPNPDHPQVPTITLPLPGSSVDQLCVDILHSEKPMKLFVDPSQGLEVTGKYENTGFSWLEVTIQKPHLQVHATPERLVVTRGRKNTEYKWKKTLFSVLPGLKMTMNMMGLLQLSGPDKVTIGLLSLDDPQRGLMLLLNDTQHFSNNVKGELGQFYRDIVWEPPVEPDNTKRTVKVQGVDYLATRELKLSYQEGFPGAEISCWTVEI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
56	Methylation	AHTVVTSRVVNRADA CCEEEEEHHHCHHHH		18967735
81	N-linked_Glycosylation	PRKAFITNFSMIIDG CCCEEEEEEEEEECC		16944957
103	Ubiquitination	KEKAEAQKQYSAAVG HHHHHHHHHHHCHHC		22790023
103	Ubiquitination	KEKAEAQKQYSAAVG HHHHHHHHHHHCHHC		22790023
185	Phosphorylation	IFEPQGISILETEST EECCCCEEEEECCCC		-
224	Ubiquitination	PTLSQQQKSQSEQDT CCCCHHHCCHHHCCC		22790023
224	Ubiquitination	PTLSQQQKSQSEQDT CCCCHHHCCHHHCCC		22790023
336	Ubiquitination	ATEENLNKAVNYASR HHHHHHHHHHHHHHH		22790023
336	Ubiquitination	ATEENLNKAVNYASR HHHHHHHHHHHHHHH		22790023
517	N-linked_Glycosylation	SGQMHMQNITFQTEA CCCEEEEEEEEECHH		16944957
577	N-linked_Glycosylation	ALEAQVLNLSLKYNF HHHHHHHCHHCEECE		16944957
607	Ubiquitination	EQFQVAEKPVEVGDG CCEEEECCCEECCCH		22790023
607	Ubiquitination	EQFQVAEKPVEVGDG CCEEEECCCEECCCH		22790023
641	Ubiquitination	SKLMTVLKGSRSQIP CHHHHEECCCHHHCC		22790023
641	Ubiquitination	SKLMTVLKGSRSQIP CHHHHEECCCHHHCC		22790023
643	Phosphorylation	LMTVLKGSRSQIPRL HHHEECCCHHHCCCH		24719451
702	Phosphorylation	SDFSLQPSYERMLSL CCCCCCCCHHHHHCC		-
708	Phosphorylation	PSYERMLSLPSVAAQ CCHHHHHCCCHHHHC		24719451
732	O-linked_Glycosylation	TEKSKESTIPEESPN ECCCCCCCCCCCCCC		-
798	Phosphorylation	GFSWLEVTIQKPHLQ CEEEEEEEEECCCEE		-
829	Phosphorylation	TEYKWKKTLFSVLPG CCCCHHHHHHHHHHC		18266315
832	Phosphorylation	KWKKTLFSVLPGLKM CHHHHHHHHHHCHHH		18266315
874	N-linked_Glycosylation	RGLMLLLNDTQHFSN CCEEEECCCCHHHHH		16944957

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ITIH4_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ITIH4_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ITIH4_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ITIH4_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.