ISW2_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ISW2_ARATH
• UniProt AC: Q8RWY3
• Protein Name: ISWI chromatin-remodeling complex ATPase CHR11 {ECO:0000305}
• Gene Name: CHR11 {ECO:0000303|PubMed:16286646}
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 1056
• Subcellular Localization: Nucleus .
• Protein Description: Possesses intrinsic ATP-dependent nucleosome-remodeling activity. Constitutes the catalytic subunit of several complexes capable of forming ordered nucleosome arrays on chromatin (By similarity). Involved in the formation of nucleosome distribution patterns. [PubMed: 24606212 Involved in nuclear proliferation during megagametogenesis and cell expansion in the sporophyte]
• Protein Sequence: MARNSNSDEAFSSEEEEERVKDNEEEDEEELEAVARSSGSDDDEVAAADESPVSDGEAAPVEDDYEDEEDEEKAEISKREKARLKEMQKLKKQKIQEMLESQNASIDADMNNKGKGRLKYLLQQTELFAHFAKSDGSSSQKKAKGRGRHASKITEEEEDEEYLKEEEDGLTGSGNTRLLTQPSCIQGKMRDYQLAGLNWLIRLYENGINGILADEMGLGKTLQTISLLAYLHEYRGINGPHMVVAPKSTLGNWMNEIRRFCPVLRAVKFLGNPEERRHIREDLLVAGKFDICVTSFEMAIKEKTALRRFSWRYIIIDEAHRIKNENSLLSKTMRLFSTNYRLLITGTPLQNNLHELWALLNFLLPEIFSSAETFDEWFQISGENDQQEVVQQLHKVLRPFLLRRLKSDVEKGLPPKKETILKVGMSQMQKQYYKALLQKDLEAVNAGGERKRLLNIAMQLRKCCNHPYLFQGAEPGPPYTTGDHLITNAGKMVLLDKLLPKLKERDSRVLIFSQMTRLLDILEDYLMYRGYLYCRIDGNTGGDERDASIEAYNKPGSEKFVFLLSTRAGGLGINLATADVVILYDSDWNPQVDLQAQDRAHRIGQKKEVQVFRFCTESAIEEKVIERAYKKLALDALVIQQGRLAEQKTVNKDELLQMVRYGAEMVFSSKDSTITDEDIDRIIAKGEEATAELDAKMKKFTEDAIQFKMDDSADFYDFDDDNKDENKLDFKKIVSDNWNDPPKRERKRNYSESEYFKQTLRQGAPAKPKEPRIPRMPQLHDFQFFNIQRLTELYEKEVRYLMQTHQKNQLKDTIDVEEPEEGGDPLTTEEVEEKEGLLEEGFSTWSRRDFNTFLRACEKYGRNDIKSIASEMEGKTEEEVERYAKVFKERYKELNDYDRIIKNIERGEARISRKDEIMKAIGKKLDRYRNPWLELKIQYGQNKGKLYNEECDRFMICMIHKLGYGNWDELKAAFRTSSVFRFDWFVKSRTSQELARRCDTLIRLIEKENQEFDERERQARKEKKLAKSATPSKRPLGRQASESPSSTKKRKHLSMR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MARNSNSDEAFS ---CCCCCCCCCCCC	31.96	23776212
7	Phosphorylation	-MARNSNSDEAFSSE -CCCCCCCCCCCCCH	36.33	23776212
12	Phosphorylation	SNSDEAFSSEEEEER CCCCCCCCCHHHHHH	43.84	23776212
13	Phosphorylation	NSDEAFSSEEEEERV CCCCCCCCHHHHHHH	42.44	23776212
712	Phosphorylation	IQFKMDDSADFYDFD HCCCCCCCCCCCCCC	26.02	30407730
716	Phosphorylation	MDDSADFYDFDDDNK CCCCCCCCCCCCCCC	19.09	30407730
800	Phosphorylation	LYEKEVRYLMQTHQK HHHHHHHHHHHHHCC	16.23	19880383
1041	Phosphorylation	RPLGRQASESPSSTK CCCCCCCCCCCCCHH	70.46	25561503
1043	Phosphorylation	LGRQASESPSSTKKR CCCCCCCCCCCHHHC	28.40	25561503
1045	Phosphorylation	RQASESPSSTKKRKH CCCCCCCCCHHHCCC	47.86	25561503
1046	Phosphorylation	QASESPSSTKKRKHL CCCCCCCCHHHCCCC	44.94	25561503
1047	Phosphorylation	ASESPSSTKKRKHLS CCCCCCCHHHCCCCC	53.15	19880383

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ISW2_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ISW2_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ISW2_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.