dbPTM

ISLR2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ISLR2_HUMAN
UniProt AC	Q6UXK2
Protein Name	Immunoglobulin superfamily containing leucine-rich repeat protein 2
Gene Name	ISLR2
Organism	Homo sapiens (Human).
Sequence Length	745
Subcellular Localization	Cell membrane Single-pass membrane protein.
Protein Description	Required for axon extension during neural development..
Protein Sequence	MFPLRALWLVWALLGVAGSCPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSLSANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSDLRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQLYHNPFHCGCGLVWLQAWAASTRVSLPEPDSIACASPPALQGVPVYRLPALPCAPPSVHLSAEPPLEAPGTPLRAGLAFVLHCIADGHPTPRLQWQLQIPGGTVVLEPPVLSGEDDGVGAEEGEGEGDGDLLTQTQAQTPTPAPAWPAPPATPRFLALANGSLLVPLLSAKEAGVYTCRAHNELGANSTSIRVAVAATGPPKHAPGAGGEPDGQAPTSERKSTAKGRGNSVLPSKPEGKIKGQGLAKVSILGETETEPEEDTSEGEEAEDQILADPAEEQRCGNGDPSRYVSNHAFNQSAELKPHVFELGVIALDVAEREARVQLTPLAARWGPGPGGAGGAPRPGRRPLRLLYLCPAGGGAAVQWSRVEEGVNAYWFRGLRPGTNYSVCLALAGEACHVQVVFSTKKELPSLLVIVAVSVFLLVLATVPLLGAACCHLLAKHPGKPYRLILRPQAPDPMEKRIAADFDPRASYLESEKSYPAGGEAGGEEPEDVQGEGLDEDAEQGDPSGDLQREESLAACSLVESQSKANQEEFEAGSEYSDRLPLGAEAVNIAQEINGNYRQTAG

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
52	N-linked_Glycosylation	VPEGLPANVTTLSLS CCCCCCCCCEEEEEC	29.72	UniProtKB CARBOHYD
99	Phosphorylation	PGALAVLSQLKNLDL CCHHHHHHHHCCCCC	27.20	24719451
121	N-linked_Glycosylation	FPWSDLRNLSALQLL CCHHHHCCHHHHHHH	45.72	UniProtKB CARBOHYD
137	Phosphorylation	MNHNRLGSLPRDALG CCCCCCCCCCHHHHC	39.53	24719451
337	N-linked_Glycosylation	PRFLALANGSLLVPL HHHHHCCCCCEEEEC	41.24	UniProtKB CARBOHYD
364	N-linked_Glycosylation	AHNELGANSTSIRVA CCCCCCCCCCEEEEE	43.98	UniProtKB CARBOHYD
375	Phosphorylation	IRVAVAATGPPKHAP EEEEEECCCCCCCCC	40.25	23403867
411	Phosphorylation	RGNSVLPSKPEGKIK CCCCCCCCCCCCCCC	57.59	24719451
474	N-linked_Glycosylation	YVSNHAFNQSAELKP HHHCCCCCCCCCCCC	35.36	UniProtKB CARBOHYD
563	N-linked_Glycosylation	RGLRPGTNYSVCLAL CCCCCCCCHHHHHHH	32.75	UniProtKB CARBOHYD
650	Phosphorylation	ADFDPRASYLESEKS CCCCCCHHHHHCCCC	31.37	25921289
651	Phosphorylation	DFDPRASYLESEKSY CCCCCHHHHHCCCCC	17.32	25884760
654	Phosphorylation	PRASYLESEKSYPAG CCHHHHHCCCCCCCC	47.96	25921289
717	Phosphorylation	QEEFEAGSEYSDRLP HHHHHHCCCCHHCCC	40.17	25921289
719	Phosphorylation	EFEAGSEYSDRLPLG HHHHCCCCHHCCCCC	19.98	-
720	Phosphorylation	FEAGSEYSDRLPLGA HHHCCCCHHCCCCCH	16.53	25921289
740	Phosphorylation	AQEINGNYRQTAG-- HHHHCCCCCCCCC--	12.90	25884760

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ISLR2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ISLR2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ISLR2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of ISLR2_HUMAN !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ISLR2_HUMAN

Related Literatures of Post-Translational Modification