IRX4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IRX4_HUMAN
• UniProt AC: P78413
• Protein Name: Iroquois-class homeodomain protein IRX-4
• Gene Name: IRX4
• Organism: Homo sapiens (Human).
• Sequence Length: 519
• Subcellular Localization: Nucleus .
• Protein Description: Likely to be an important mediator of ventricular differentiation during cardiac development..
• Protein Sequence: MSYPQFGYPYSSAPQFLMATNSLSTCCESGGRTLADSGPAASAQAPVYCPVYESRLLATARHELNSAAALGVYGGPYGGSQGYGNYVTYGSEASAFYSLNSFDSKDGSGSAHGGLAPAAAAYYPYEPALGQYPYDRYGTMDSGTRRKNATRETTSTLKAWLQEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWPPRNKCADEKRPYAEGEEEEGGEEEAREEPLKSSKNAEPVGKEEKELELSDLDDFDPLEAEPPACELKPPFHSLDGGLERVPAAPDGPVKEASGALRMSLAAGGGAALDEDLERARSCLRSAAAGPEPLPGAEGGPQVCEAKLGFVPAGASAGLEAKPRIWSLAHTATAAAAAATSLSQTEFPSCMLKRQGPAAPAAVSSAPATSPSVALPHSGALDRHQDSPVTSLRNWVDGVFHDPILRHSTLNQAWATAKGALLDPGPLGRSLGAGANVLTAPLARAFPPAVPQDAPAAGAARELLALPKAGGKPFCA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSYPQFGYP ------CCCCCCCCC	45.58	24043423
3	Phosphorylation	-----MSYPQFGYPY -----CCCCCCCCCC	10.35	24043423
8	Phosphorylation	MSYPQFGYPYSSAPQ CCCCCCCCCCCCCCH	10.57	24043423
10	Phosphorylation	YPQFGYPYSSAPQFL CCCCCCCCCCCCHHH	13.53	24043423
11	Phosphorylation	PQFGYPYSSAPQFLM CCCCCCCCCCCHHHH	18.60	24043423
12	Phosphorylation	QFGYPYSSAPQFLMA CCCCCCCCCCHHHHH	37.82	24043423
20	Phosphorylation	APQFLMATNSLSTCC CCHHHHHCCCHHHHH	16.04	24043423
22	Phosphorylation	QFLMATNSLSTCCES HHHHHCCCHHHHHHC	21.24	24043423
24	Phosphorylation	LMATNSLSTCCESGG HHHCCCHHHHHHCCC	21.15	24043423
25	Phosphorylation	MATNSLSTCCESGGR HHCCCHHHHHHCCCC	26.86	24043423
29	Phosphorylation	SLSTCCESGGRTLAD CHHHHHHCCCCEECC	32.41	24043423
122	Phosphorylation	LAPAAAAYYPYEPAL CCCCHHHHCCCCCCC	10.55	27642862
125	Phosphorylation	AAAAYYPYEPALGQY CHHHHCCCCCCCCCC	20.58	27642862
132	Phosphorylation	YEPALGQYPYDRYGT CCCCCCCCCCCCCCC	11.27	24905233
144	Phosphorylation	YGTMDSGTRRKNATR CCCCCCCCCCCCCCH	31.11	24905233
153	Phosphorylation	RKNATRETTSTLKAW CCCCCHHHHHHHHHH	23.82	-
153 (in isoform 2)	Phosphorylation	-	23.82	25627689
154	Phosphorylation	KNATRETTSTLKAWL CCCCHHHHHHHHHHH	18.24	19664995
158 (in isoform 2)	Phosphorylation	-	37.29	25159151
163 (in isoform 2)	Phosphorylation	-	43.41	30257219
165 (in isoform 2)	Phosphorylation	-	39.43	30257219
240	Ubiquitination	EAREEPLKSSKNAEP HHHHCCCCCCCCCCC	64.50	22817900
243	Ubiquitination	EEPLKSSKNAEPVGK HCCCCCCCCCCCCCH	68.23	21906983
258	Phosphorylation	EEKELELSDLDDFDP HHHEECCCCCCCCCC	27.10	20873877
266	Ubiquitination	DLDDFDPLEAEPPAC CCCCCCCCCCCCCCC	11.95	22817900
269	Ubiquitination	DFDPLEAEPPACELK CCCCCCCCCCCCCCC	42.30	22817900
301	Phosphorylation	DGPVKEASGALRMSL CCCHHCHHHHHHHHH	26.20	22210691
408	Phosphorylation	AAPAAVSSAPATSPS CCCHHHCCCCCCCCC	31.50	28348404
412	Phosphorylation	AVSSAPATSPSVALP HHCCCCCCCCCCCCC	39.86	28348404
413	Phosphorylation	VSSAPATSPSVALPH HCCCCCCCCCCCCCC	19.79	25159151
415	Phosphorylation	SAPATSPSVALPHSG CCCCCCCCCCCCCCC	21.57	28348404
430	Phosphorylation	ALDRHQDSPVTSLRN CCCCCCCCCCHHHHH	18.07	20873877
473	Phosphorylation	DPGPLGRSLGAGANV CCCHHHHHCCCCCCE	29.38	25159151

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IRX4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IRX4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IRX4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RARA_HUMAN	RARA	physical	11382777

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.