IRE1A_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IRE1A_ARATH
• UniProt AC: Q9C5S2
• Protein Name: Serine/threonine-protein kinase/endoribonuclease IRE1a
• Gene Name: IRE1A
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 841
• Subcellular Localization: Endoplasmic reticulum membrane ; Single-pass type I membrane protein .
• Protein Description: Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices bZIP60 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator which then induces transcription of UPR target genes. Involved in organ growth regulation. Plays a role in plant immunity and abiotic stress responses..
• Protein Sequence: MPPRCPFLRHLFFLLLLLSPWIMSPCGGAADDVTYPIVPSSPGRRSILQIRREPPTEPNTKLVVDRDGKVFLKQQPKETPYWSFSTGSPMHSLYQAPANNNTENATEITRPHIIVEYLNNSKAATTVDGYHNWTVQEFFRQKPLVTDDGVTLGSETTSAYLVDGRSGRLIHVYKSTGDTKITNALVKPASTEDFVNEPLLIRRTDSKLEHFSKTTGKLVWNLTVSHFRAALLCDPVFNSGYDLGPKLQTGIYMPLLCGSQIDVRGPEIVIRVLHDQPMNVKMLPSPSLNHFESENSIMPFGKARESRKLQEQHKQKYTYLFGQWSPVKLLAPLVLLGVVVSVFIKKFSSRGSDVSLKAGPSKKKKNRKSAKDTNRQSVPRGQDQFELIEGGQMLLGFNNFQSGATDGRKIGKLFLSSKEIAKGSNGTVVFEGIYEGRPVAVKRLVRSHHEVAFKEIQNLIASDQHTNIIRWYGVEYDQDFVYLSLERCTCSLDDLIKSYLEFSMTKVLENNDSTEGVAAYKIQLDSLEGVIKGNNFWKVGGHPSPLMLKLMRDIVCGIVHLHELGIVHRDLKPQNVLISKDMTLSAKLSDMGISKRMSRDMSSLGHLATGSGSSGWQAPEQLLQGRQTRAVDMFSLGCVIFYTITGCKHPFGDDLERDVNIVKNKVDLFLVEHVPEASDLISRLLNPDPDLRPSATEVLLHPMFWNSEMRLSFLRDASDRVELENREADSEILKAMESTAPVAIGGKWDEKLEPVFITNIGRYRRYKYDSIRDLLRVIRNKLNHHRELPPEIQELVGTVPEGFDEYFAVRFPKLLIEVYRVISLHCREEEVFRKYFKCDII

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
100	N-linked_Glycosylation	LYQAPANNNTENATE CEECCCCCCCCCCCC		-
104	N-linked_Glycosylation	PANNNTENATEITRP CCCCCCCCCCCCCCC		-
119	N-linked_Glycosylation	HIIVEYLNNSKAATT EEEEEECCCCCCCEE		-
132	N-linked_Glycosylation	TTVDGYHNWTVQEFF EEECCCCCCCHHHHH		-
221	N-linked_Glycosylation	TTGKLVWNLTVSHFR HCCCHHHEEEHHHHH		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IRE1A_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IRE1A_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IRE1A_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of IRE1A_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.