| UniProt ID | IRAK3_MOUSE | |
|---|---|---|
| UniProt AC | Q8K4B2 | |
| Protein Name | Interleukin-1 receptor-associated kinase 3 | |
| Gene Name | Irak3 {ECO:0000312|MGI:MGI:1921164} | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 609 | |
| Subcellular Localization | ||
| Protein Description | Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex.. | |
| Protein Sequence | MAGRCGARGALSPQLLLFDLPPALLGELCGILDSCDGPLGWRGLAERLSNSWLDVRHIEKYVNQGKSGTRELLWSWAQKNKTIGDLLEVLQDMGHQRAIHLIINYGVSWTPSVQTHHELPFPSFPPEVKHACRENDPGPLEPANVTVDNVLVPEHNEKGTLQKTPISFQSILEGTKHFHKDFLIGEGEIFEVYRVDIRNQAYAVKLFKQEKKMQLKKHWKRFLSELEVLLLFRHPHILELAAYFTETEKLCLVYPYMSNGTLFDRLQCTNGTTPLSWHVRISVLIGIAKAIQYLHNTQPCAVICGNVSSANILLDDQLQPKLTDFAAAHFRPNLEQQSSTINMTGGGRKHLWYMPEEYIRQGRLSVKTDVYSFGIVIMEVLTGCKVVLDDPKHVQLRDLLMELMEKRGLDSCLSFLDRKIPPCPRNFSAKLFSLAGRCVATKAKLRPTMDEVLSSLESTQPSLYFAEDPPTSLKSFRCPSPLFLDNVPSIPVEDDENQNNHSVPPKEVLGTDRVTQKTPFECSQSEVTFLGLDRNRGNRGSEADCNVPSSSHEECWSPELVAPSQDLSPTVISLGSSWEVPGHSYGSKPMEKRCSSGLFCSEHEQSKKQ | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 51 | Phosphorylation | LAERLSNSWLDVRHI HHHHHHCCCEEHHHH | 26.16 | 22942356 | |
| 164 | Phosphorylation | EKGTLQKTPISFQSI CCCCCCCCCCCHHHH | 16.94 | 29472430 | |
| 167 | Phosphorylation | TLQKTPISFQSILEG CCCCCCCCHHHHHCC | 20.59 | 29472430 | |
| 170 | Phosphorylation | KTPISFQSILEGTKH CCCCCHHHHHCCCCC | 27.42 | 22982522 | |
| 428 | Phosphorylation | PPCPRNFSAKLFSLA CCCCCCHHHHHHHHH | 28.22 | 24719451 | |
| 475 | Phosphorylation | DPPTSLKSFRCPSPL CCCCCCHHCCCCCCC | 24.18 | 26745281 | |
| 480 | Phosphorylation | LKSFRCPSPLFLDNV CHHCCCCCCCCCCCC | 37.55 | 26745281 | |
| 489 | Phosphorylation | LFLDNVPSIPVEDDE CCCCCCCCCCCCCCC | 34.93 | 26745281 | |
| 523 | Phosphorylation | QKTPFECSQSEVTFL CCCCCCCCCCCEEEE | 29.55 | 24719451 | |
| 595 | Phosphorylation | KPMEKRCSSGLFCSE CCCHHHCCCCCCCCH | 31.32 | 26745281 | |
| 596 | Phosphorylation | PMEKRCSSGLFCSEH CCHHHCCCCCCCCHH | 43.04 | 26745281 | |
| 601 | Phosphorylation | CSSGLFCSEHEQSKK CCCCCCCCHHHHHCC | 34.35 | 26745281 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of IRAK3_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of IRAK3_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of IRAK3_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of IRAK3_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Protein phosphorylation and expression profiling by Yin-yangmultidimensional liquid chromatography (Yin-yang MDLC) massspectrometry."; Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.; J. Proteome Res. 6:250-262(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-601, AND MASSSPECTROMETRY. | |
