IQEC2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IQEC2_HUMAN
• UniProt AC: Q5JU85
• Protein Name: IQ motif and SEC7 domain-containing protein 2
• Gene Name: IQSEC2
• Organism: Homo sapiens (Human).
• Sequence Length: 1488
• Subcellular Localization: Cytoplasm .
• Protein Description: Is a guanine nucleotide exchange factor for the ARF GTP-binding proteins..
• Protein Sequence: MEAGSGPPGGPGSESPNRAVEYLLELNNIIESQQQLLETQRRRIEELEGQLDQLTQENRDLREESQLHRGELHRDPHGARDSPGRESQYQNLRETQFHHRELRESQFHQAARDVGYPNREGAYQNREAVYRDKERDASYPLQDTTGYTARERDVAQCHLHHENPALGRERGGREAGPAHPGREKEAGYSAAVGVGPRPPRERGQLSRGASRSSSPGAGGGHSTSTSTSPATTLQRKSDGENSRTVSVEGDAPGSDLSTAVDSPGSQPPYRLSQLPPSSSHMGGPPAGVGLPWAQRARLQPASVALRKQEEEEIKRSKALSDSYELSTDLQDKKVEMLERKYGGSFLSRRAARTIQTAFRQYRMNKNFERLRSSASESRMSRRIILSNMRMQFSFEEYEKAQNPAYFEGKPASLDEGAMAGARSHRLERGLPYGGSCGGGIDGGGSSVTTSGEFSNDITELEDSFSKQVKSLAESIDEALNCHPSGPMSEEPGSAQLEKRESKEQQEDSSATSFSDLPLYLDDTVPQQSPERLPSTEPPPQGRPEFWAPAPLPPVPPPVPSGTREDGSREEGTRRGPGCLECRDFRLRAAHLPLLTIEPPSDSSVDLSDRSDRGSVHRQLVYEADGCSPHGTLKHKGPPGRAPIPHRHYPAPEGPAPAPPGPLPPAPNSGTGPSGVAGGRRLGKCEAAGENSDGGDNESLESSSNSNETINCSSGSSSRDSLREPPATGLCKQTYQRETRHSWDSPAFNNDVVQRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCNPALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDLLVGIYQRIQGRELRTNDDHVSQVQAVERMIVGKKPVLSLPHRRLVCCCQLYEVPDPNRPQRLGLHQREVFLFNDLLVVTKIFQKKKILVTYSFRQSFPLVEMHMQLFQNSYYQFGIKLLSAVPGGERKVLIIFNAPSLQDRLRFTSDLRESIAEVQEMEKYRVESELEKQKGMMRPNASQPGGAKDSVNGTMARSSLEDTYGAGDGLKRGALSSSLRDLSDAGKRGRRNSVGSLDSTIEGSVISSPRPHQRMPPPPPPPPPEEYKSQRPVSNSSSFLGSLFGSKRGKGPFQMPPPPTGQASASSSSASSTHHHHHHHHHGHSHGGLGVLPDGQSKLQALHAQYCQGPGPAPPPYLPPQQPSLPPPPQQPPPLPQLGSIPPPPASAPPVGPHRHFHAHGPVPGPQHYTLGRPGRAPRRGAGGHPQFAPHGRHPLHQPTSPLPLYSPAPQHPPAHKQGPKHFIFSHHPQMMPAAGAAGGPGSRPPGGSYSHPHHPQSPLSPHSPIPPHPSYPPLPPPSPHTPHSPLPPTSPHGPLHASGPPGTANPPSANPKAKPSRISTVV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	PGGPGSESPNRAVEY CCCCCCCCHHHHHHH	29.22	-
40 (in isoform 3)	Phosphorylation	-	27.75	28348404
41 (in isoform 3)	Phosphorylation	-	36.95	28348404
55	Phosphorylation	EGQLDQLTQENRDLR HHHHHHHHHHCHHHH	28.36	29449344
82	Phosphorylation	DPHGARDSPGRESQY CCCCCCCCCCCHHHH	24.57	29449344
87	Phosphorylation	RDSPGRESQYQNLRE CCCCCCHHHHHHHHH	32.59	28152594
89	Phosphorylation	SPGRESQYQNLRETQ CCCCHHHHHHHHHHH	14.51	24927040
105	Phosphorylation	HHRELRESQFHQAAR HHHHHHHHHHHHHHH	31.54	24719451
138	Phosphorylation	RDKERDASYPLQDTT CCCCCCCCCCCCCCC	31.41	-
139	Phosphorylation	DKERDASYPLQDTTG CCCCCCCCCCCCCCC	15.07	-
144	Phosphorylation	ASYPLQDTTGYTARE CCCCCCCCCCCCHHH	14.79	30576142
188	Phosphorylation	GREKEAGYSAAVGVG CCCCCCCCCCCCCCC	11.37	18083107
189	Phosphorylation	REKEAGYSAAVGVGP CCCCCCCCCCCCCCC	14.61	24719451
207	Methylation	RERGQLSRGASRSSS CCCCCCCCCCCCCCC	53.97	115480451
210	Phosphorylation	GQLSRGASRSSSPGA CCCCCCCCCCCCCCC	35.20	30257219
212	Phosphorylation	LSRGASRSSSPGAGG CCCCCCCCCCCCCCC	32.45	28450419
212 (in isoform 2)	Phosphorylation	-	32.45	21406692
213	Phosphorylation	SRGASRSSSPGAGGG CCCCCCCCCCCCCCC	39.17	28450419
213 (in isoform 2)	Phosphorylation	-	39.17	21406692
214	Phosphorylation	RGASRSSSPGAGGGH CCCCCCCCCCCCCCC	28.71	28188228
214 (in isoform 2)	Phosphorylation	-	28.71	21406692
222	Phosphorylation	PGAGGGHSTSTSTSP CCCCCCCCCCCCCCC	27.59	28450419
222 (in isoform 2)	Phosphorylation	-	27.59	21406692
223	Phosphorylation	GAGGGHSTSTSTSPA CCCCCCCCCCCCCCC	30.28	28450419
223 (in isoform 2)	Phosphorylation	-	30.28	21406692
224	Phosphorylation	AGGGHSTSTSTSPAT CCCCCCCCCCCCCCC	24.31	28450419
224 (in isoform 2)	Phosphorylation	-	24.31	21406692
225	Phosphorylation	GGGHSTSTSTSPATT CCCCCCCCCCCCCCC	35.79	28450419
225 (in isoform 2)	Phosphorylation	-	35.79	21406692
226	Phosphorylation	GGHSTSTSTSPATTL CCCCCCCCCCCCCCE	27.01	28450419
226 (in isoform 2)	Phosphorylation	-	27.01	21406692
227	Phosphorylation	GHSTSTSTSPATTLQ CCCCCCCCCCCCCEE	38.53	28450419
227 (in isoform 2)	Phosphorylation	-	38.53	21406692
228	Phosphorylation	HSTSTSTSPATTLQR CCCCCCCCCCCCEEE	16.59	28450419
228 (in isoform 2)	Phosphorylation	-	16.59	21406692
231	Phosphorylation	STSTSPATTLQRKSD CCCCCCCCCEEECCC	31.27	28450419
231 (in isoform 2)	Phosphorylation	-	31.27	21406692
232	Phosphorylation	TSTSPATTLQRKSDG CCCCCCCCEEECCCC	24.01	28450419
232 (in isoform 2)	Phosphorylation	-	24.01	21406692
244 (in isoform 2)	Phosphorylation	-	34.03	24719451
246 (in isoform 2)	Phosphorylation	-	5.40	26657352
248	Phosphorylation	NSRTVSVEGDAPGSD CCCEEEEECCCCCCC	37.69	28985074
254 (in isoform 2)	Phosphorylation	-	42.75	24076635
262 (in isoform 2)	Phosphorylation	-	22.22	24719451
265 (in isoform 2)	Phosphorylation	-	21.06	24076635
292	Phosphorylation	PAGVGLPWAQRARLQ CCCCCCCHHHHHCCC	18.01	22985185
310	Phosphorylation	VALRKQEEEEIKRSK HHHHHHHHHHHHHHH	29.39	27499020
312	Phosphorylation	LRKQEEEEIKRSKAL HHHHHHHHHHHHHHH	19.68	27499020
313	Phosphorylation	RKQEEEEIKRSKALS HHHHHHHHHHHHHHH	26.36	25307156
316	Phosphorylation	EEEEIKRSKALSDSY HHHHHHHHHHHHHHH	14.13	28348404
317	Phosphorylation	EEEIKRSKALSDSYE HHHHHHHHHHHHHHH	54.04	27251275
331	Phosphorylation	ELSTDLQDKKVEMLE HCCHHHHHHHHHHHH	32.70	23186163
334	Phosphorylation	TDLQDKKVEMLERKY HHHHHHHHHHHHHHH	20.74	22617229
337	Phosphorylation	QDKKVEMLERKYGGS HHHHHHHHHHHHCCC	20.08	23090842
344	Phosphorylation	LERKYGGSFLSRRAA HHHHHCCCHHHHHHH	2.60	23186163
362	Phosphorylation	QTAFRQYRMNKNFER HHHHHHHHHCCCHHH	34.54	30576142
363	Phosphorylation	TAFRQYRMNKNFERL HHHHHHHHCCCHHHH	29.40	30576142
383	Phosphorylation	ESRMSRRIILSNMRM HHHHHHHHHHHHCCE	18.17	30266825
387	Phosphorylation	SRRIILSNMRMQFSF HHHHHHHHCCEEECH	18.61	29978859
393	Phosphorylation	SNMRMQFSFEEYEKA HHCCEEECHHHHHHH	19.09	21406692
395	Phosphorylation	MRMQFSFEEYEKAQN CCEEECHHHHHHHCC	11.92	23312004
399	Acetylation	FSFEEYEKAQNPAYF ECHHHHHHHCCCHHH	30.16	20167786
402	Phosphorylation	EEYEKAQNPAYFEGK HHHHHHCCCHHHCCC	44.90	22617229
412	Phosphorylation	YFEGKPASLDEGAMA HHCCCCCCCCCCCCC	31.88	23186163
425	Phosphorylation	MAGARSHRLERGLPY CCHHHHHCCCCCCCC	12.77	29802988
435	Phosphorylation	RGLPYGGSCGGGIDG CCCCCCCCCCCCCCC	25.55	28348404
436	Phosphorylation	GLPYGGSCGGGIDGG CCCCCCCCCCCCCCC	27.10	29802988
438	Phosphorylation	PYGGSCGGGIDGGGS CCCCCCCCCCCCCCC	19.72	28348404
439	Phosphorylation	YGGSCGGGIDGGGSS CCCCCCCCCCCCCCC	32.36	28348404
440	Phosphorylation	GGSCGGGIDGGGSSV CCCCCCCCCCCCCCC	27.28	28348404
444	Phosphorylation	GGGIDGGGSSVTTSG CCCCCCCCCCCCCCC	29.32	28348404
448	Phosphorylation	DGGGSSVTTSGEFSN CCCCCCCCCCCCCCC	37.06	28348404
453	Phosphorylation	SVTTSGEFSNDITEL CCCCCCCCCCCCHHH	23.26	24719451
460	Phosphorylation	FSNDITELEDSFSKQ CCCCCHHHHHHHHHH	33.67	27499020
464	Phosphorylation	ITELEDSFSKQVKSL CHHHHHHHHHHHHHH	29.72	28857561
491	Phosphorylation	SGPMSEEPGSAQLEK CCCCCCCCCCHHHHH	45.59	-
501	Phosphorylation	AQLEKRESKEQQEDS HHHHHHHCHHHHCCC	32.05	-
518	Phosphorylation	TSFSDLPLYLDDTVP CCHHHCCCCCCCCCC	24.39	-
528	Phosphorylation	DDTVPQQSPERLPST CCCCCCCCCCCCCCC	27.84	-
590	Phosphorylation	DFRLRAAHLPLLTIE HHCCEECCCCEEEEC	61.92	24076635
592	Phosphorylation	RLRAAHLPLLTIEPP CCEECCCCEEEECCC	36.28	28348404
593	Phosphorylation	LRAAHLPLLTIEPPS CEECCCCEEEECCCC	25.33	28348404
597	Phosphorylation	HLPLLTIEPPSDSSV CCCEEEECCCCCCCC	26.89	27251275
600	Phosphorylation	LLTIEPPSDSSVDLS EEEECCCCCCCCCCC	36.33	27251275
604	Phosphorylation	EPPSDSSVDLSDRSD CCCCCCCCCCCCCCC	18.68	27251275
607	Phosphorylation	SDSSVDLSDRSDRGS CCCCCCCCCCCCCCC	29.40	-
611	Phosphorylation	VDLSDRSDRGSVHRQ CCCCCCCCCCCHHHH	17.62	21945579
617	Phosphorylation	SDRGSVHRQLVYEAD CCCCCHHHHHHHCCC	26.01	21945579
621	Phosphorylation	SVHRQLVYEADGCSP CHHHHHHHCCCCCCC	29.60	21945579
623	Methylation	HRQLVYEADGCSPHG HHHHHHCCCCCCCCC	43.01	-
627	Phosphorylation	VYEADGCSPHGTLKH HHCCCCCCCCCCCCC	32.73	-
681	Phosphorylation	GVAGGRRLGKCEAAG CCCCCCCCCCCEECC	33.07	28348404
688	Phosphorylation	LGKCEAAGENSDGGD CCCCEECCCCCCCCC	43.63	28348404
691	Phosphorylation	CEAAGENSDGGDNES CEECCCCCCCCCCCC	44.34	28348404
692	Phosphorylation	EAAGENSDGGDNESL EECCCCCCCCCCCCC	24.94	28348404
693	Phosphorylation	AAGENSDGGDNESLE ECCCCCCCCCCCCCC	54.26	28348404
695	Phosphorylation	GENSDGGDNESLESS CCCCCCCCCCCCCCC	37.68	28348404
710	Phosphorylation	SNSNETINCSSGSSS CCCCCCEECCCCCCC	28.37	28985074
717	Phosphorylation	NCSSGSSSRDSLREP ECCCCCCCCHHCCCC	36.14	22985185
728	Phosphorylation	LREPPATGLCKQTYQ CCCCCCCCCCHHHHC	35.55	30183078
731	Phosphorylation	PPATGLCKQTYQRET CCCCCCCHHHHCCCC	29.32	30183078
734	Phosphorylation	TGLCKQTYQRETRHS CCCCHHHHCCCCCCC	16.33	28450419
741	Phosphorylation	YQRETRHSWDSPAFN HCCCCCCCCCCCCCC	4.25	-
744	Phosphorylation	ETRHSWDSPAFNNDV CCCCCCCCCCCCCHH	18.74	-
883	Phosphorylation	RNPDTIFILAFAIIL CCHHHHHHHHHHHHH	23.32	29083192
886	Phosphorylation	DTIFILAFAIILLNT HHHHHHHHHHHHHCC	21.90	29083192
887	Phosphorylation	TIFILAFAIILLNTD HHHHHHHHHHHHCCC	12.22	29083192
889	Phosphorylation	FILAFAIILLNTDMY HHHHHHHHHHCCCCC	30.24	29083192
897	Acetylation	LLNTDMYSPSVKAER HHCCCCCCCCHHHHH	52.37	-
923	Phosphorylation	RGVDNGEDIPRDLLV CCCCCCCCCCHHHHH	5.94	27196784
936 (in isoform 3)	Phosphorylation	-	46.27	28450419
937 (in isoform 3)	Phosphorylation	-	24.80	28450419
938 (in isoform 3)	Phosphorylation	-	5.72	19664995
943 (in isoform 3)	Phosphorylation	-	13.29	28102081
949 (in isoform 3)	Phosphorylation	-	7.22	28102081
969	Phosphorylation	KPVLSLPHRRLVCCC CCCCCCCCCCEEEEE	6.76	28152594
1097	Phosphorylation	RVESELEKQKGMMRP HHHHHHHHHCCCCCC	43.48	23186163
1107	Phosphorylation	GMMRPNASQPGGAKD CCCCCCCCCCCCCHH	44.14	23186163
1113	Phosphorylation	ASQPGGAKDSVNGTM CCCCCCCHHCCCCCC	29.72	28857561
1114	Phosphorylation	SQPGGAKDSVNGTMA CCCCCCHHCCCCCCC	30.17	28857561
1118	Phosphorylation	GAKDSVNGTMARSSL CCHHCCCCCCCCHHH	17.93	24719451
1119	Phosphorylation	AKDSVNGTMARSSLE CHHCCCCCCCCHHHH	19.80	29978859
1123	Phosphorylation	VNGTMARSSLEDTYG CCCCCCCHHHHHCCC	59.73	18452278
1129	Phosphorylation	RSSLEDTYGAGDGLK CHHHHHCCCCCCHHH	14.33	18452278
1131	Phosphorylation	SLEDTYGAGDGLKRG HHHHCCCCCCHHHHC	19.83	30266825
1132	Phosphorylation	LEDTYGAGDGLKRGA HHHCCCCCCHHHHCH	33.95	30266825
1133	Phosphorylation	EDTYGAGDGLKRGAL HHCCCCCCHHHHCHH	24.85	30266825
1138	Phosphorylation	AGDGLKRGALSSSLR CCCHHHHCHHHHHHH	29.69	23663014
1142	Ubiquitination	LKRGALSSSLRDLSD HHHCHHHHHHHHHHH	54.09	-
1143	Phosphorylation	KRGALSSSLRDLSDA HHCHHHHHHHHHHHH	42.82	23186163
1148	Phosphorylation	SSSLRDLSDAGKRGR HHHHHHHHHHHHHCC	26.50	21406692
1151	Phosphorylation	LRDLSDAGKRGRRNS HHHHHHHHHHCCCCC	27.18	21406692
1154	Phosphorylation	LSDAGKRGRRNSVGS HHHHHHHCCCCCCCC	36.26	29449344
1155	Phosphorylation	SDAGKRGRRNSVGSL HHHHHHCCCCCCCCC	23.78	22210691
1158	Phosphorylation	GKRGRRNSVGSLDST HHHCCCCCCCCCCCC	24.30	-
1161	Phosphorylation	GRRNSVGSLDSTIEG CCCCCCCCCCCCCCC	3.46	-
1162	Phosphorylation	RRNSVGSLDSTIEGS CCCCCCCCCCCCCCC	31.94	24719451
1163	Phosphorylation	RNSVGSLDSTIEGSV CCCCCCCCCCCCCCC	17.50	24719451
1172	Phosphorylation	TIEGSVISSPRPHQR CCCCCCCCCCCCCCC	44.69	-
1173	Phosphorylation	IEGSVISSPRPHQRM CCCCCCCCCCCCCCC	48.43	-
1182	Phosphorylation	RPHQRMPPPPPPPPP CCCCCCCCCCCCCCC	17.80	28165663
1335	Methylation	VPGPQHYTLGRPGRA CCCCCCCCCCCCCCC	37.95	-
1345	Methylation	RPGRAPRRGAGGHPQ CCCCCCCCCCCCCCC	31.58	-
1446	Phosphorylation	PLPPPSPHTPHSPLP CCCCCCCCCCCCCCC	22.22	-
1468	Methylation	LHASGPPGTANPPSA CCCCCCCCCCCCCCC	69.70	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IQEC2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IQEC2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IQEC2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CCDC8_HUMAN	CCDC8	physical	27173435
RAC1_HUMAN	RAC1	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 309530: Mental retardation, X-linked 1 (MRX1)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.