dbPTM

IPP_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	IPP_MOUSE
UniProt AC	P28575
Protein Name	Actin-binding protein IPP
Gene Name	Ipp
Organism	Mus musculus (Mouse).
Sequence Length	584
Subcellular Localization	Cytoplasm, cytoskeleton.
Protein Description	May play a role in organizing the actin cytoskeleton..
Protein Sequence	MSKEECPKAADNSFSSDKHAQLILAQMNKMRSGQHFCDVQLQVGKETFQVHRLVLAASSPYFAALFTGGMKESSKDVVQILGVEAGIFQLLLDFIYTGVVNIAVTNVQELIVAADMLQLTEVVNLCCDFLKGQIDPQNCIGLFQFSEQIACHDLLEFTENYIHVHFLEVHTGEEFLGLTKDQLIKILRSEELSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPVRFPLLPSQRLLKYIEGVSDFNLRVALQTLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARCGLGVAVVGGMVYAIGGEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGSMAVSRYYFGCCEMQGLIYAVGGISNEGLELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYAIGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCAVTVNGLLYVSGGRSSSHDFLAPGTLDSVEVYNPHSDTWTEIGNMITSRCEGGVAVL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
233	Phosphorylation	VRFPLLPSQRLLKYI CCCCCCCHHHHHHHH	28.09	24719451
265	Phosphorylation	EYCEVCKSPKENKFC HHHHHCCCCCCCCCC	35.76	25266776
267	Acetylation	CEVCKSPKENKFCSF HHHCCCCCCCCCCCH	79.57	15216301
279	Acetylation	CSFLQTSKVRPRKKA CCHHHCCCCCCCHHH	3.11	15216293
428	Phosphorylation	GSMAVSRYYFGCCEM EEHHHHHHHCCHHHH	8.81	25293948
429	Phosphorylation	SMAVSRYYFGCCEMQ EHHHHHHHCCHHHHC	7.74	25293948
440	Phosphorylation	CEMQGLIYAVGGISN HHHCCCEEEECCCCC	10.56	25293948
446	Phosphorylation	IYAVGGISNEGLELR EEEECCCCCCCCEEE	31.91	25293948

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of IPP_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of IPP_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of IPP_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
ACTS_MOUSE	Acta1	physical	11536049

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of IPP_MOUSE

Related Literatures of Post-Translational Modification