IPIL2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IPIL2_HUMAN
• UniProt AC: Q3MIP1
• Protein Name: Inositol 1,4,5-trisphosphate receptor-interacting protein-like 2
• Gene Name: ITPRIPL2
• Organism: Homo sapiens (Human).
• Sequence Length: 535
• Subcellular Localization: Membrane; Single-pass type I membrane protein.
• Protein Sequence: MSVHYTLNLRVFWPLVTGLCTALVCLYHVLRGSGGARAEPADGVDGGFPLLKVAVLLLLSYVLLRCRHAVRQRFLPGSPRLEGHAAFSSRHFREPGLSILLESYYEHEVRLSPHVLGHSKAHVSRIVGELVRAGRARGSPGLIPGGALALAFRGDFIQVGSAYEQHKIRRPDSFDVLVPLRLPPLVALEPRSLGEEPALAPAFRGCFLCALKAPPSPSGASGGHWLRDCKPFADAFCVDVRGRRHLSATLVLRWFQSHLQRSLATVRYSLEGRCRVTLTPGGLEQPPTLHILPCRTDYGCCRLSMAVRLIPAVHLGDGVFLVAPPPPPLPSAPLLELPEGLRAEALWGVNTARQEQKLLSWLQERAAPGACYLKCLQLLKALRDLGARGLDSAAATQWGRILSSYVLKTVLLAVLLRKGAPGQGWDEEHLGRCLEELVQFLRDCLLRRHTLFHCVLGPGGAAAEVGPLPKALREAAPVDLLAAFDGHARELAAARLLSTWQRLPQLLRAYGGPRYLARCPPPRSQRTQGFLEGEP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
60	Phosphorylation	VAVLLLLSYVLLRCR HHHHHHHHHHHHHHH	17.11	24670416
78	Phosphorylation	RQRFLPGSPRLEGHA HHCCCCCCCCCCCCC	12.61	30266825
88	Phosphorylation	LEGHAAFSSRHFREP CCCCCCCCCCCCCCC	23.03	24719451
89	Phosphorylation	EGHAAFSSRHFREPG CCCCCCCCCCCCCCC	24.26	28387310
139	Phosphorylation	RAGRARGSPGLIPGG HHHHCCCCCCCCCCH	15.39	25850435
167	Sumoylation	GSAYEQHKIRRPDSF CCHHHHCCCCCCCCC	37.29	-
167	Ubiquitination	GSAYEQHKIRRPDSF CCHHHHCCCCCCCCC	37.29	29901268
173	Phosphorylation	HKIRRPDSFDVLVPL CCCCCCCCCCEEEEC	26.48	23312004
216	Phosphorylation	CALKAPPSPSGASGG EEECCCCCCCCCCCC	30.55	26270265
218	Phosphorylation	LKAPPSPSGASGGHW ECCCCCCCCCCCCCC	51.86	26270265

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IPIL2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IPIL2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IPIL2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of IPIL2_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.