IP5PD_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IP5PD_ARATH
• UniProt AC: Q9SYK4
• Protein Name: Type I inositol polyphosphate 5-phosphatase 13 {ECO:0000303|PubMed:15574849}
• Gene Name: IP5P13 {ECO:0000305}
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 1136
• Subcellular Localization: Nucleus .
• Protein Description: Converts inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) to inositol 1,4-bisphosphate. Modulates cotyledon vein development through regulating auxin homeostasis. Involved in blue light responses. Decreases the amount of KIN10 degraded by the proteasome under low nutrient conditions. Participates with IP5P12 in the control of Ins(1,4,5)P3/Ca(2+) levels that is crucial for maintaining pollen dormancy and regulating early germination of pollen. May modulate auxin transport by regulating vesicle trafficking and thereby plays a role in root gravitropism..
• Protein Sequence: MDSLIIEEEDEEALATLVPVPPRRKTHSYSLQFDHKPHHQIRKHSLDEVPRSATLASEAVYFDSSDDEFSTGGNITENAADETNAGAEEYTIVNPPPNVGLGDDDTEPLPEFIGAGGGSGIFKVPVRAAVHPGRPPCLELRPHPLRETQTGRFLRNIACTETQLWAGQENGIRFWNLEDAYEAGCGIGGQVPRGDEDTAPFHESVTTSPTMCLVADQSNKLLWSGHKDGKIRAWKMDQSSVSHDDDDSDPFKERVSWLAHRGPVNSIVISSYGDMWSCSEGGVIKIWPWDTLEKSLLLKPEEKHMAALLVERSAIDLRSQVTVNGTCSISSSEVKFLLADSVRAKVWAVQSLSFSIWDARSKDLLKVLNVDGQVENRGDLPPIQDQQVDDEMKLKFFSASKREKPQGFLQRSRNAIMGAAGAVRRVATRSAGAFSEDTRKTEAIVLAVDGTIWTGSISGLIVQWDGNGNRLRDVNHHHRPVLCFCTFGDRIYVGYASGYIQVLDLDGKLISSWVSHNEPVIKLAAGGGFIFSLATHGGVRGWYVTSPGPLDNIIRTELSQKETLYARQDNVRILIGTWNVGQGRASHDALMSWLGSVTSDVGIVAVGLQEVEMGAGFLAMSAAKETVGLEGSAVGQWWIDAIGKALDEKNTFERMGSRQLAGLLISLWARKDIRTHVGDLDVAAVPCGFGRAIGNKGGVGLRIRVYDRIMCFVNCHLAAHLEAVNRRNADFNHIFRLMVFSRGQNLSNAAAAGVSTSAYTTKSNTIPSTGAEEIKSDLAAADMVAFFGDFNYRLFGITYDEARDFISQRSFDWLRERDQLRAEMKVGKVFQGMREALITFPPTYKFERNRSGLGGYDSGEKKRIPAWCDRVIYRDTQSSPFSESNLQCPVVSSVIMYEACMDVTESDHKPVRCKFHATIAHVDKSVRRQELGKIIRSNEKILSIFEDLRFVPETSVSTNNIVLQSQDTVILTITNNSPTSQAIFNILCGGQAVVKDDGEDADYNPRGSFGLPRWLEVSPAAGIINPEGSVDVKVHHEDFYSMEEYVDGIPQNWWCEDTRDKEAILMVNIRGSCSTTLRSHSVKVRHCFSARVCLLENRPTNLTKNLGGSRRYPTDITRNGSTRPRTEDSVRRGKSR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
26	Phosphorylation	PVPPRRKTHSYSLQF ECCCCCCCEEEEEEC	17.78	25368622
28	Phosphorylation	PPRRKTHSYSLQFDH CCCCCCEEEEEECCC	22.96	25368622
29	Phosphorylation	PRRKTHSYSLQFDHK CCCCCEEEEEECCCC	13.04	25368622
30	Phosphorylation	RRKTHSYSLQFDHKP CCCCEEEEEECCCCC	20.79	25368622
45	Phosphorylation	HHQIRKHSLDEVPRS CHHHCCCCCCCCCCC	40.32	19880383
757	Phosphorylation	AAAGVSTSAYTTKSN HHCCCCCCCCCCCCC	16.27	23111157
759	Phosphorylation	AGVSTSAYTTKSNTI CCCCCCCCCCCCCCC	18.08	23111157

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IP5PD_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IP5PD_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IP5PD_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of IP5PD_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.