IP3KA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IP3KA_HUMAN
• UniProt AC: P23677
• Protein Name: Inositol-trisphosphate 3-kinase A
• Gene Name: ITPKA
• Organism: Homo sapiens (Human).
• Sequence Length: 461
• Protein Sequence: MTLPGGPTGMARPGGARPCSPGLERAPRRSVGELRLLFEARCAAVAAAAAAGEPRARGAKRRGGQVPNGLPRAPPAPVIPQLTVTAEEPDVPPTSPGPPERERDCLPAAGSSHLQQPRRLSTSSVSSTGSSSLLEDSEDDLLSDSESRSRGNVQLEAGEDVGQKNHWQKIRTMVNLPVISPFKKRYAWVQLAGHTGSFKAAGTSGLILKRCSEPERYCLARLMADALRGCVPAFHGVVERDGESYLQLQDLLDGFDGPCVLDCKMGVRTYLEEELTKARERPKLRKDMYKKMLAVDPEAPTEEEHAQRAVTKPRYMQWREGISSSTTLGFRIEGIKKADGSCSTDFKTTRSREQVLRVFEEFVQGDEEVLRRYLNRLQQIRDTLEVSEFFRRHEVIGSSLLFVHDHCHRAGVWLIDFGKTTPLPDGQILDHRRPWEEGNREDGYLLGLDNLIGILASLAER

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
20	Phosphorylation	PGGARPCSPGLERAP CCCCCCCCCCCCCCC	25.37	30266825
35	Methylation	RRSVGELRLLFEARC CCCHHHHHHHHHHHH	25.66	-
55	Methylation	AAAAGEPRARGAKRR HHHCCCCCHHCCHHC	32.39	-
62	Methylation	RARGAKRRGGQVPNG CHHCCHHCCCCCCCC	53.54	58858031
83	Phosphorylation	APVIPQLTVTAEEPD CCCCCEEEEEECCCC	15.57	23312004
85	Phosphorylation	VIPQLTVTAEEPDVP CCCEEEEEECCCCCC	24.10	23312004
94	Phosphorylation	EEPDVPPTSPGPPER CCCCCCCCCCCCCHH	41.29	26657352
95	Phosphorylation	EPDVPPTSPGPPERE CCCCCCCCCCCCHHH	33.36	26657352
121	Phosphorylation	LQQPRRLSTSSVSST CCCCCCCCCCCCCCC	25.16	26657352
122	Phosphorylation	QQPRRLSTSSVSSTG CCCCCCCCCCCCCCC	29.61	26434776
123	Phosphorylation	QPRRLSTSSVSSTGS CCCCCCCCCCCCCCC	25.93	26434776
124	Phosphorylation	PRRLSTSSVSSTGSS CCCCCCCCCCCCCCC	26.55	26434776
126	Phosphorylation	RLSTSSVSSTGSSSL CCCCCCCCCCCCCHH	24.91	26434776
127	Phosphorylation	LSTSSVSSTGSSSLL CCCCCCCCCCCCHHC	34.33	26434776
128	Phosphorylation	STSSVSSTGSSSLLE CCCCCCCCCCCHHCC	33.31	26434776
130	Phosphorylation	SSVSSTGSSSLLEDS CCCCCCCCCHHCCCC	19.49	26434776
131	Phosphorylation	SVSSTGSSSLLEDSE CCCCCCCCHHCCCCC	26.75	26657352
132	Phosphorylation	VSSTGSSSLLEDSED CCCCCCCHHCCCCCC	38.38	26434776
137	Phosphorylation	SSSLLEDSEDDLLSD CCHHCCCCCCCCCCC	33.28	26434776
143	Phosphorylation	DSEDDLLSDSESRSR CCCCCCCCCCCHHCC	46.52	26434776
145	Phosphorylation	EDDLLSDSESRSRGN CCCCCCCCCHHCCCC	33.81	26434776
147	Phosphorylation	DLLSDSESRSRGNVQ CCCCCCCHHCCCCEE	39.24	26434776
180	Phosphorylation	MVNLPVISPFKKRYA HHCCCCCCCCHHCEE	25.23	22199227
195	Phosphorylation	WVQLAGHTGSFKAAG EEECCCCCCCCCCCC	33.34	28857561
197	Phosphorylation	QLAGHTGSFKAAGTS ECCCCCCCCCCCCCC	25.40	28857561
209	Ubiquitination	GTSGLILKRCSEPER CCCCEEEECCCCHHH	44.35	30230243
311	Phosphorylation	EHAQRAVTKPRYMQW HHHHHHHHCHHHHHH	34.05	9155020
323	Phosphorylation	MQWREGISSSTTLGF HHHHCCCCCCCEEEE	29.15	-
325	Phosphorylation	WREGISSSTTLGFRI HHCCCCCCCEEEEEE	20.72	28060719
326	Phosphorylation	REGISSSTTLGFRIE HCCCCCCCEEEEEEE	28.17	28060719
327	Phosphorylation	EGISSSTTLGFRIEG CCCCCCCEEEEEEEE	27.17	28060719
337	Ubiquitination	FRIEGIKKADGSCST EEEEEEECCCCCCCC	50.19	30230243
419	Ubiquitination	VWLIDFGKTTPLPDG EEEEECCCCCCCCCC	49.58	30230243

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
311	T	Phosphorylation	Kinase	KCC2A	Q9UQM7	PhosphoELM
311	T	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
311	T	Phosphorylation	Kinase	PKC_GROUP	-	PhosphoELM

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IP3KA_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IP3KA_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of IP3KA_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.