dbPTM

INT3_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	INT3_DROME
UniProt AC	Q7PLS8
Protein Name	Integrator complex subunit 3 {ECO:0000303\|PubMed:21078872}
Gene Name	IntS3 {ECO:0000312\|FlyBase:FBgn0262117}
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	1068
Subcellular Localization	Nucleus . Cytoplasm .
Protein Description	Component of the Integrator complex, a complex involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box-dependent processing. [PubMed: 21078872]
Protein Sequence	MEQQQSKNNAHVSKLFICTAVDCKDDIEEKFERSFVTLQMQISGLSDKEMHDMLSQAVCKEKQHEEISIGFLYIMLTDPSMASKTYRDVTLVSRDGMNGIVTNLTFLVAEKYTKLTEVARRQLIWLLREFVKHQVLSVENVIWNCLRQAGGGDVSSRNLFLIESLLDIFIEFRTWLETNPFLVQSTVYSFVRLIEDHANPALLSLRQKEVKFTISLIRERFHDIIPLGRDFVRLLQNVARIPEFEQLWRDILFNPKMLHQTFNGIWQLLHIRTSRRFLQCRLLPEMERKISFLASSVKFGNQKRYQDWFQDKYFATPESHSLRSDLIRFIINVIHPTNDMLCSDIIPRWAIIGWLISSCTNPIASANAKLSLFYDWLFFDPAKDNIMNIEPGILVMYHSIRNHPFVSSTLLDFLCRITKNFFVKHEDKIRIGVYNSLKLILEKQVIPNLQPLFESPKLDRELRNLIRDNFREFLSPPANHGQLLFTSLHPVQGHILKKESDQRILHCENMDLHETGLINISGTIDEDKKILLVPTDQEIESVFSDETAENLRRVHNIEDNTDDDDDLPLSEVRLKEKPKVELAEAIAESFDAFVTKRNSYTWEAFLKDFRPLPASAFEEFQLNYVISNTVLILRETLPQQNIFSESKTEEKHLAKSISYPLYGLFRFLYENDEKSKKPFQTLLSEICEGIPEIGYLLLYFMKIYCKLQTRKNSQQSYQFKTTIYRQICDAADEKIGNCLLRDLDLLEKENTNIFLWLLPDIYREFKSIATNNTDLLRITLRCIDAKNVRDILYSIAQGKLTIFKQDGLIDCIRQSLEFETYEQFCLWQIVQAHDVPLRCIQDILPELEAGSHPEALSHFLLLLKNEEPTNEIIRLMLSRESKSKGDPFVTSALRFWCQRYEEKLSEIIASLLTSKYPSSSPNKRKRPPKGISVSTSTPSADQVLNHLEHYRRSCRHGTGTGLYVHDMMQRALQSAYSHSNDSTKKQFCDLFALAAEEDTTVGRRGGSGRGRKQPGSKKDVNNHGTSKKNPEMVKTIYSSDDNSSEEDWSKSKILQTAKRRKKANNDSD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
561	Phosphorylation	VHNIEDNTDDDDDLP HHCCCCCCCCCCCCC	53.80	19429919
919	Phosphorylation	LTSKYPSSSPNKRKR HHCCCCCCCCCCCCC	45.36	25749252
1035	Phosphorylation	KNPEMVKTIYSSDDN CCHHHHEEEECCCCC	17.46	19429919
1037	Phosphorylation	PEMVKTIYSSDDNSS HHHHEEEECCCCCCC	13.83	19429919
1038	Phosphorylation	EMVKTIYSSDDNSSE HHHEEEECCCCCCCH	24.36	19429919
1039	Phosphorylation	MVKTIYSSDDNSSEE HHEEEECCCCCCCHH	31.82	19429919
1043	Phosphorylation	IYSSDDNSSEEDWSK EECCCCCCCHHHHHH	46.23	19429919
1044	Phosphorylation	YSSDDNSSEEDWSKS ECCCCCCCHHHHHHH	51.78	19429919
1049	Phosphorylation	NSSEEDWSKSKILQT CCCHHHHHHHHHHHH	39.10	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of INT3_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of INT3_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of INT3_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of INT3_DROME !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of INT3_DROME

Related Literatures of Post-Translational Modification