INT13_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: INT13_DROME
• UniProt AC: Q9VEX5
• Protein Name: Protein asunder {ECO:0000303|PubMed:19357193}
• Gene Name: Asun {ECO:0000312|FlyBase:FBgn0020407}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 689
• Subcellular Localization: Nucleus . Cytoplasm . Cytoplasm, perinuclear region . Colocalizes with dynein-dynactin on the nuclear surface at the meiotic G2/prophase transition in primary spermatocytes (PubMed:19357193). Nuclear location is required for recruitment of dynein mot
• Protein Description: Component of the Integrator complex, a complex involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box-dependent processing. [PubMed: 23097424 Involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1 and U5]
• Protein Sequence: MFERNQKTIFVLDHTRYFSIASEEYISMDFLKGKPSADGGATGAAGNATGSGGSQFSKSLWTCACESSIEYCRVVWDLFPGKKHVRFIVSDTAAHIVNTWRPSTQNMAHVMNAMLIVGVPSRNVPTSSDYSVIHGLRAAIEALAEPTDEQLAAMADFGTDELPRIPNKGRVICITSARDNTSMKSLEDIFNTVLVQQNTLAAPPSKKGLVIDHCHLVILNIVPLGVESLVTNRSLLKISPLLDVEIHTVSAPDISYKLTHLILNHYDLASTTVTNIPMKEEQNANSSANYDVEILHSRRAHSITCGPDFSLPTSIKQGATYETVTLKWCTPRGCGSADLQPCLGQFLVTPVDVTSRPSSCLINFLLNGRSVLLEMPRKTGSKATSHMLSARGGEIFVHSLCITRSCMDEAPSITDGPGGRVSDYRTAELGQLIKMSRVVPLKVKDPSAPPLTRRLPRYFPLTTSSSILFHLQRHISWLPHFLHLLVKEDMDKQDEVRCQQHIHELYKSASRGDVLPFTHTNGARLKLSKAKDQYRLLYRELEQLIQLNATTMHHKNLLESLQSLRAAYGDAPLKSEPGASLLRTYTESPLSPERLEPISSVGASGSSSSNSLLKASKRRMSSCGQRSLLDIISSAERSQSNKRLDFSGRLCTPLGQVAKLYPDFGTKDKDTVTTGASITPNVKEESVRS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
588	Phosphorylation	LLRTYTESPLSPERL HEEEECCCCCCHHHC		22817900
591	Phosphorylation	TYTESPLSPERLEPI EECCCCCCHHHCCCC		22817900
621	Phosphorylation	KASKRRMSSCGQRSL HHHHHHHHCCCCHHH		19429919
622	Phosphorylation	ASKRRMSSCGQRSLL HHHHHHHCCCCHHHH		19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of INT13_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of INT13_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of INT13_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DYHC_DROME	Dhc64C	genetic	19357193

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.