INP4B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: INP4B_HUMAN
• UniProt AC: O15327
• Protein Name: Type II inositol 3,4-bisphosphate 4-phosphatase
• Gene Name: INPP4B
• Organism: Homo sapiens (Human).
• Sequence Length: 924
• Protein Description: Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate..
• Protein Sequence: MEIKEEGASEEGQHFLPTAQANDPGDCQFTSIQKTPNEPQLEFILACKDLVAPVRDRKLNTLVQISVIHPVEQSLTRYSSTEIVEGTRDPLFLTGVTFPSEYPIYEETKIKLTVYDVKDKSHDTVRTSVLPEHKDPPPEVGRSFLGYASFKVGELLKSKEQLLVLSLRTSDGGKVVGTIEVSVVKMGEIEDGEADHITTDVQGQKCALVCECTAPESVSGKDNLPFLNSVLKNPVCKLYRFPTSDNKWMRIREQMSESILSFHIPKELISLHIKEDLCRNQEIKELGELSPHWDNLRKNVLTHCDQMVNMYQDILTELSKETGSSFKSSSSKGEKTLEFVPINLHLQRMQVHSPHLKDALYDVITVGAPAAHFQGFKNGGLRKLLHRFETERRNTGYQFIYYSPENTAKAKEVLSNINQLQPLIATHADLLLNSASQHSPDSLKNSLKMLSEKTELFVHAFKDQLVRSALLALYTARPGGILKKPPSPKSSTEESSPQDQPPVMRGQDSIPHHSDYDEEEWDRVWANVGKSLNCIIAMVDKLIERDGGSEGSGGNNDGEKEPSLTDAIPSHPREDWYEQLYPLILTLKDCMGEVVNRAKQSLTFVLLQELAYSLPQCLMLTLRRDIVFSQALAGLVCGFIIKLQTSLYDPGFLQQLHTVGLIVQYEGLLSTYSDEIGMLEDMAVGISDLKKVAFKIIEAKSNDVLPVITGRREHYVVEVKLPARMFESLPLQIKEGQLLHVYPVLFNVGINEQQTLAERFGDVSLQESINQENFELLQEYYKIFMEKMPPDYISHFQEQNDLKALLENLLQNIQSKKRKNVEIMWLAATICRKLNGIRFTCCKSAKDRTSMSVTLEQCSILRDEHQLHKDFFIRALDCMRREGCRIENVLKNIKCRKYAFNMLQLMAFPKYYRPPEGTYGKADT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
35	Phosphorylation	QFTSIQKTPNEPQLE CEEECEECCCCCCHH	18.25	27251275
61	Phosphorylation	VRDRKLNTLVQISVI CCCCCCCCEEEEEEE	38.45	-
66	Phosphorylation	LNTLVQISVIHPVEQ CCCEEEEEEEECCCC	9.64	-
74	Phosphorylation	VIHPVEQSLTRYSST EEECCCCCCCCCCCC	20.43	-
76	Phosphorylation	HPVEQSLTRYSSTEI ECCCCCCCCCCCCCC	32.57	-
79	Phosphorylation	EQSLTRYSSTEIVEG CCCCCCCCCCCCEEC	27.74	28348404
80	Phosphorylation	QSLTRYSSTEIVEGT CCCCCCCCCCCEECC	22.56	28348404
81	Phosphorylation	SLTRYSSTEIVEGTR CCCCCCCCCCEECCC	24.64	28348404
87	Phosphorylation	STEIVEGTRDPLFLT CCCCEECCCCCCEEE	20.56	28348404
94	Phosphorylation	TRDPLFLTGVTFPSE CCCCCEEECCCCCCC	23.44	26074081
97	Phosphorylation	PLFLTGVTFPSEYPI CCEEECCCCCCCCCC	31.04	26074081
100	Phosphorylation	LTGVTFPSEYPIYEE EECCCCCCCCCCCCC	45.64	26074081
102	Phosphorylation	GVTFPSEYPIYEETK CCCCCCCCCCCCCCE	10.16	26074081
105	Phosphorylation	FPSEYPIYEETKIKL CCCCCCCCCCCEEEE	11.83	26074081
108	Phosphorylation	EYPIYEETKIKLTVY CCCCCCCCEEEEEEE	26.57	26074081
113	Phosphorylation	EETKIKLTVYDVKDK CCCEEEEEEEECCCC	16.42	28102081
115	Phosphorylation	TKIKLTVYDVKDKSH CEEEEEEEECCCCCC	15.13	28102081
121	Phosphorylation	VYDVKDKSHDTVRTS EEECCCCCCCCEEEC	36.41	-
147	Phosphorylation	VGRSFLGYASFKVGE CCHHHHHHHHHHHHH	10.96	-
149	Phosphorylation	RSFLGYASFKVGELL HHHHHHHHHHHHHHH	19.67	24719451
198	Phosphorylation	DGEADHITTDVQGQK CCCCCCEEECCCCCE	17.33	18452278
237	Ubiquitination	VLKNPVCKLYRFPTS HHCCCCCEEEECCCC	49.11	-
270	Phosphorylation	HIPKELISLHIKEDL CCCHHHHHHHHHHHH	26.90	-
290	Phosphorylation	IKELGELSPHWDNLR HHHHHHCCCCHHHHH	15.49	23898821
353	Phosphorylation	LQRMQVHSPHLKDAL EEECCCCCHHHHHHH	18.37	-
361	Phosphorylation	PHLKDALYDVITVGA HHHHHHHHHHEECCC	15.19	27642862
397	Phosphorylation	TERRNTGYQFIYYSP HCCCCCCCEEEEECC	9.75	27642862
401	Phosphorylation	NTGYQFIYYSPENTA CCCCEEEEECCCCHH	10.12	27642862
448	Acetylation	DSLKNSLKMLSEKTE HHHHHHHHHHHHHHH	37.30	20167786
462	2-Hydroxyisobutyrylation	ELFVHAFKDQLVRSA HHHHHHHHHHHHHHH	45.40	-
468	Phosphorylation	FKDQLVRSALLALYT HHHHHHHHHHHHHHH	18.78	-
487	Phosphorylation	GILKKPPSPKSSTEE CCCCCCCCCCCCCCC	54.19	28176443
490	Phosphorylation	KKPPSPKSSTEESSP CCCCCCCCCCCCCCC	45.97	28270605
491	Phosphorylation	KPPSPKSSTEESSPQ CCCCCCCCCCCCCCC	46.06	28270605
492	Phosphorylation	PPSPKSSTEESSPQD CCCCCCCCCCCCCCC	51.36	28270605
495	Phosphorylation	PKSSTEESSPQDQPP CCCCCCCCCCCCCCC	40.88	30278072
496	Phosphorylation	KSSTEESSPQDQPPV CCCCCCCCCCCCCCC	29.84	25849741
509	Phosphorylation	PVMRGQDSIPHHSDY CCCCCCCCCCCCCCC	30.08	23401153
516	Phosphorylation	SIPHHSDYDEEEWDR CCCCCCCCCHHHHHH	28.41	27642862
552	Phosphorylation	RDGGSEGSGGNNDGE CCCCCCCCCCCCCCC	39.20	25056879
563	Phosphorylation	NDGEKEPSLTDAIPS CCCCCCCCHHHCCCC	45.02	27251275
565	Phosphorylation	GEKEPSLTDAIPSHP CCCCCCHHHCCCCCC	27.94	27251275
601	Phosphorylation	VVNRAKQSLTFVLLQ HHHHHHHHHHHHHHH	28.77	24043423
603	Phosphorylation	NRAKQSLTFVLLQEL HHHHHHHHHHHHHHH	19.56	24043423
612	Phosphorylation	VLLQELAYSLPQCLM HHHHHHHHCHHHHHH	24.30	24043423
613	Phosphorylation	LLQELAYSLPQCLML HHHHHHHCHHHHHHH	28.15	24043423
621	Phosphorylation	LPQCLMLTLRRDIVF HHHHHHHHHHHHHHH	12.31	23532336
629	Phosphorylation	LRRDIVFSQALAGLV HHHHHHHHHHHHHHH	12.03	25404012
792	Phosphorylation	MEKMPPDYISHFQEQ HHHCCHHHHHHHHHH	15.31	17322306
794	Phosphorylation	KMPPDYISHFQEQND HCCHHHHHHHHHHHH	16.42	17322306
898	Phosphorylation	KNIKCRKYAFNMLQL HHCCCHHHHHHHHHH	9.32	22817900
919	Phosphorylation	YRPPEGTYGKADT-- CCCCCCCCCCCCC--	27.73	27642862

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of INP4B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of INP4B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of INP4B_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of INP4B_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.