INO80_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: INO80_ARATH
• UniProt AC: Q8RXS6
• Protein Name: Chromatin-remodeling ATPase INO80 {ECO:0000305}
• Gene Name: INO80
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 1507
• Subcellular Localization: Nucleus .
• Protein Description: ATPase component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and DNA repair (By similarity). Binds DNA (By similarity). As part of the INO80 complex, remodels chromatin by shifting nucleosomes (By similarity). Positive regulator of homologous recombination, but not an essential component of homologous recombination. [PubMed: 15525519 Not involved in the illegitimate repair pathway]
• Protein Sequence: MDPSRRPPKDSPYANLFDLEPLMKFRIPKPEDEVDYYGSSSQDESRSTQGGVVANYSNGSKSRMNASSKKRKRWTEAEDAEDDDDLYNQHVTEEHYRSMLGEHVQKFKNRSKETQGNPPHLMGFPVLKSNVGSYRGRKPGNDYHGRFYDMDNSPNFAADVTPHRRGSYHDRDITPKIAYEPSYLDIGDGVIYKIPPSYDKLVASLNLPSFSDIHVEEFYLKGTLDLRSLAELMASDKRSGVRSRNGMGEPRPQYESLQARMKALSPSNSTPNFSLKVSEAAMNSAIPEGSAGSTARTILSEGGVLQVHYVKILEKGDTYEIVKRSLPKKLKAKNDPAVIEKTERDKIRKAWINIVRRDIAKHHRIFTTFHRKLSIDAKRFADGCQREVRMKVGRSYKIPRTAPIRTRKISRDMLLFWKRYDKQMAEERKKQEKEAAEAFKREQEQRESKRQQQRLNFLIKQTELYSHFMQNKTDSNPSEALPIGDENPIDEVLPETSAAEPSEVEDPEEAELKEKVLRAAQDAVSKQKQITDAFDTEYMKLRQTSEMEGPLNDISVSGSSNIDLHNPSTMPVTSTVQTPELFKGTLKEYQMKGLQWLVNCYEQGLNGILADEMGLGKTIQAMAFLAHLAEEKNIWGPFLVVAPASVLNNWADEISRFCPDLKTLPYWGGLQERTILRKNINPKRMYRRDAGFHILITSYQLLVTDEKYFRRVKWQYMVLDEAQAIKSSSSIRWKTLLSFNCRNRLLLTGTPIQNNMAELWALLHFIMPMLFDNHDQFNEWFSKGIENHAEHGGTLNEHQLNRLHAILKPFMLRRVKKDVVSELTTKTEVTVHCKLSSRQQAFYQAIKNKISLAELFDSNRGQFTDKKVLNLMNIVIQLRKVCNHPELFERNEGSSYLYFGVTSNSLLPHPFGELEDVHYSGGQNPIIYKIPKLLHQEVLQNSETFCSSVGRGISRESFLKHFNIYSPEYILKSIFPSDSGVDQVVSGSGAFGFSRLMDLSPSEVGYLALCSVAERLLFSILRWERQFLDELVNSLMESKDGDLSDNNIERVKTKAVTRMLLMPSKVETNFQKRRLSTGPTRPSFEALVISHQDRFLSSIKLLHSAYTYIPKARAPPVSIHCSDRNSAYRVTEELHQPWLKRLLIGFARTSEANGPRKPNSFPHPLIQEIDSELPVVQPALQLTHRIFGSCPPMQSFDPAKLLTDSGKLQTLDILLKRLRAGNHRVLLFAQMTKMLNILEDYMNYRKYKYLRLDGSSTIMDRRDMVRDFQHRSDIFVFLLSTRAGGLGINLTAADTVIFYESDWNPTLDLQAMDRAHRLGQTKDVTVYRLICKETVEEKILHRASQKNTVQQLVMTGGHVQGDDFLGAADVVSLLMDDAEAAQLEQKFRELPLQVKDRQKKKTKRIRIDAEGDATLEELEDVDRQDNGQEPLEEPEKPKSSNKKRRAASNPKARAPQKAKEEANGEDTPQRTKRVKRQTKSINESLEPVFSASVTESNKGFDPSSSAN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
39	Phosphorylation	DEVDYYGSSSQDESR HCCCCCCCCCCCCCC	15.64	27531888
40	Phosphorylation	EVDYYGSSSQDESRS CCCCCCCCCCCCCCC	27.88	27531888
41	Phosphorylation	VDYYGSSSQDESRST CCCCCCCCCCCCCCC	43.26	27531888
265	Phosphorylation	QARMKALSPSNSTPN HHHHHHHCCCCCCCC	31.01	30291188
1034	Phosphorylation	FLDELVNSLMESKDG HHHHHHHHHHHCCCC	22.93	19880383
1467	Phosphorylation	EEANGEDTPQRTKRV HHHCCCCCHHHHHHH	19.61	30407730
1504	Phosphorylation	NKGFDPSSSAN---- CCCCCCCCCCC----	38.57	25561503
1505	Phosphorylation	KGFDPSSSAN----- CCCCCCCCCC-----	35.85	25561503

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of INO80_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of INO80_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of INO80_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of INO80_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.