INO1_MOUSE - dbPTM
INO1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID INO1_MOUSE
UniProt AC Q9JHU9
Protein Name Inositol-3-phosphate synthase 1
Gene Name Isyna1
Organism Mus musculus (Mouse).
Sequence Length 557
Subcellular Localization Cytoplasm.
Protein Description Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner. Rate-limiting enzyme in the synthesis of all inositol-containing compounds (By similarity)..
Protein Sequence MEPAAEILVDSPDVVYSPETIEARYEYRTTRVSREGGVLRVQPRATRFTFRTARQVPRLGVMLVGWGGNNGSTLTAAVLANRLRLTWPTRTGRKEANYYGSLTQAGTVNLGLDENGREVFVPFSALLPMVAPNDLVFDGWDISSLNLAEAMRRAQVLDCGLQEQLWPHMESLRPRPSVYIPEFIAANQTARADNLIPGTRAQQLEQIRKDIRDFRSSAGLDKVIVLWTANTERFCEVVPGRNDTAENLLHTIQLGLEVSPSTLFAVASILEDCAFLNGSPQNTLVPGALELASQRHVFVGGDDFKSGQTKVKSVLVDFLIGSGLKTMSIVSYNHLGNNDGQNLSAPLQFRSKEVTKSSVVDDMVHSNHVLYAPGERPDHCVVIKYVPYVGDSKRALDEYTSELMLGGTNTLVLHNTCEDSLLAAPIMLDLVLLTELCQRVSFCTDSDPEPQGFHTVLSLLSFLFKAPLVPPGSPVVNALFRQRSCIENIFRACVGLPPQNHMLLEHKMERPGPGIKPGEVVATSPLPCKKEPTPATNGCTGDANGHPQAPTPKLSTA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
16PhosphorylationVDSPDVVYSPETIEA
ECCCCCCCCHHHHHH		20.5325293948
17PhosphorylationDSPDVVYSPETIEAR
CCCCCCCCHHHHHHH		12.4925293948
20PhosphorylationDVVYSPETIEARYEY
CCCCCHHHHHHHEEE		27.7425293948
25PhosphorylationPETIEARYEYRTTRV
HHHHHHHEEEECEEE		25.1022871156
29PhosphorylationEARYEYRTTRVSREG
HHHEEEECEEEEECC		20.3222871156
30PhosphorylationARYEYRTTRVSREGG
HHEEEECEEEEECCC		21.7822871156
159GlutathionylationRRAQVLDCGLQEQLW
HHHCHHHHHHHHHHH		5.2524333276
312UbiquitinationKSGQTKVKSVLVDFL
CCCCHHHHHHHHHHH		36.08-
380GlutathionylationPGERPDHCVVIKYVP
CCCCCCCEEEEEECC		3.2224333276
385PhosphorylationDHCVVIKYVPYVGDS
CCEEEEEECCCCCCH		8.7825195567
473PhosphorylationAPLVPPGSPVVNALF
CCCCCCCCHHHHHHH		21.9423984901
484PhosphorylationNALFRQRSCIENIFR
HHHHHCHHHHHHHHH		15.8822942356
485GlutathionylationALFRQRSCIENIFRA
HHHHCHHHHHHHHHH		5.0124333276
485S-palmitoylationALFRQRSCIENIFRA
HHHHCHHHHHHHHHH		5.0128680068
493GlutathionylationIENIFRACVGLPPQN
HHHHHHHHHCCCCCC		1.8624333276
523PhosphorylationKPGEVVATSPLPCKK
CCCCEEECCCCCCCC		21.1920469934
524PhosphorylationPGEVVATSPLPCKKE
CCCEEECCCCCCCCC		18.0726824392
533PhosphorylationLPCKKEPTPATNGCT
CCCCCCCCCCCCCCC		27.0125367039
536PhosphorylationKKEPTPATNGCTGDA
CCCCCCCCCCCCCCC		33.0925367039
539GlutathionylationPTPATNGCTGDANGH
CCCCCCCCCCCCCCC		4.1124333276
540PhosphorylationTPATNGCTGDANGHP
CCCCCCCCCCCCCCC		39.2225367039
551PhosphorylationNGHPQAPTPKLSTA-
CCCCCCCCCCCCCC-		35.7525367039
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of INO1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of INO1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of INO1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of INO1_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of INO1_MOUSE

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Related Literatures of Post-Translational Modification

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