INMT_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: INMT_MOUSE
• UniProt AC: P40936
• Protein Name: Indolethylamine N-methyltransferase
• Gene Name: Inmt
• Organism: Mus musculus (Mouse).
• Sequence Length: 264
• Subcellular Localization: Cytoplasm .
• Protein Description: Catalyzes the N-methylation of tryptamine and structurally related compounds (By similarity). Functions as thioether S-methyltransferase and is active with a variety of thioethers and the corresponding selenium and tellurium compounds, including 3-methylthiopropionaldehyde, dimethyl selenide, dimethyl telluride, 2-methylthioethylamine, 2-methylthioethanol, methyl-n-propyl sulfide and diethyl sulfide. Plays an important role in the detoxification of selenium compounds..
• Protein Sequence: MEGKVYIGGEDYEKEFTPKDYLTTYYSFHSGPVAEQEIVKFSLQNLYQTFSTGGVGGDVLIDIGSGPTIYQLLSACEVFREIIVTDYTPQNLQELQKWLKKEPGAYDWSSIVQHACELEGDRSRWQEKEAKLRRTVTRVLRCDVTKTPPLGSAQVPLADCVLTFLAMECACPDIDTYRAALRRLAGLLKPGGHLVTLVTLRFQHYMVGPKKFSGVYLEKEVVEKAIQDAGCQVLKCNCVSLSYSEAYCSHDGLCFVVARKGPSA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Succinylation	----MEGKVYIGGED ----CCCEEEECCCC	20.68	23954790
6	Phosphorylation	--MEGKVYIGGEDYE --CCCEEEECCCCCC	9.42	20469934
14	Ubiquitination	IGGEDYEKEFTPKDY ECCCCCCCCCCCHHH	52.47	-
14	Succinylation	IGGEDYEKEFTPKDY ECCCCCCCCCCCHHH	52.47	-
14	Malonylation	IGGEDYEKEFTPKDY ECCCCCCCCCCCHHH	52.47	26320211
14	Succinylation	IGGEDYEKEFTPKDY ECCCCCCCCCCCHHH	52.47	23806337
14	Acetylation	IGGEDYEKEFTPKDY ECCCCCCCCCCCHHH	52.47	23806337
19	Acetylation	YEKEFTPKDYLTTYY CCCCCCCHHHHEEEE	56.82	23954790
19	Ubiquitination	YEKEFTPKDYLTTYY CCCCCCCHHHHEEEE	56.82	22790023
30	Phosphorylation	TTYYSFHSGPVAEQE EEEEEECCCCCCHHH	42.66	23984901
87	Phosphorylation	REIIVTDYTPQNLQE HHHHCCCCCHHHHHH	15.79	25195567
97	Acetylation	QNLQELQKWLKKEPG HHHHHHHHHHHHCCC	68.09	23806337
97	Succinylation	QNLQELQKWLKKEPG HHHHHHHHHHHHCCC	68.09	-
97	Ubiquitination	QNLQELQKWLKKEPG HHHHHHHHHHHHCCC	68.09	-
97	Succinylation	QNLQELQKWLKKEPG HHHHHHHHHHHHCCC	68.09	23806337
101	Ubiquitination	ELQKWLKKEPGAYDW HHHHHHHHCCCCCCH	67.95	-
101	Malonylation	ELQKWLKKEPGAYDW HHHHHHHHCCCCCCH	67.95	26320211
106	Phosphorylation	LKKEPGAYDWSSIVQ HHHCCCCCCHHHHHH	24.70	25521595
109	Phosphorylation	EPGAYDWSSIVQHAC CCCCCCHHHHHHHHH	13.80	25521595
116	S-palmitoylation	SSIVQHACELEGDRS HHHHHHHHHHCCCHH	6.02	28526873
128	Succinylation	DRSRWQEKEAKLRRT CHHHHHHHHHHHHHH	48.12	23954790
145	Phosphorylation	RVLRCDVTKTPPLGS HHHCCCCCCCCCCCC	18.89	23984901
147	Phosphorylation	LRCDVTKTPPLGSAQ HCCCCCCCCCCCCCC	22.29	23984901
152	Phosphorylation	TKTPPLGSAQVPLAD CCCCCCCCCCCCHHH	24.18	23984901
163	Phosphorylation	PLADCVLTFLAMECA CHHHHHHHHHHHHHC	9.01	23984901
210	Ubiquitination	QHYMVGPKKFSGVYL CCEECCCCCCCCEEE	61.60	27667366
211	Acetylation	HYMVGPKKFSGVYLE CEECCCCCCCCEEEC	48.14	23806337
211	Succinylation	HYMVGPKKFSGVYLE CEECCCCCCCCEEEC	48.14	-
211	Malonylation	HYMVGPKKFSGVYLE CEECCCCCCCCEEEC	48.14	26320211
211	Ubiquitination	HYMVGPKKFSGVYLE CEECCCCCCCCEEEC	48.14	-
213	Phosphorylation	MVGPKKFSGVYLEKE ECCCCCCCCEEECHH	35.91	29472430
216	Phosphorylation	PKKFSGVYLEKEVVE CCCCCCEEECHHHHH	16.81	20469934
219	Ubiquitination	FSGVYLEKEVVEKAI CCCEEECHHHHHHHH	53.89	-
219	Acetylation	FSGVYLEKEVVEKAI CCCEEECHHHHHHHH	53.89	23864654
219	Malonylation	FSGVYLEKEVVEKAI CCCEEECHHHHHHHH	53.89	26320211
224	Ubiquitination	LEKEVVEKAIQDAGC ECHHHHHHHHHHCCC	38.90	-
224	Acetylation	LEKEVVEKAIQDAGC ECHHHHHHHHHHCCC	38.90	23864654
224	Malonylation	LEKEVVEKAIQDAGC ECHHHHHHHHHHCCC	38.90	26320211
231	S-nitrosylation	KAIQDAGCQVLKCNC HHHHHCCCCEEEECE	2.44	21278135
231	S-palmitoylation	KAIQDAGCQVLKCNC HHHHHCCCCEEEECE	2.44	28526873
231	S-nitrosocysteine	KAIQDAGCQVLKCNC HHHHHCCCCEEEECE	2.44	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of INMT_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of INMT_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of INMT_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of INMT_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.