INCE_CHICK - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: INCE_CHICK
• UniProt AC: P53352
• Protein Name: Inner centromere protein
• Gene Name: INCENP
• Organism: Gallus gallus (Chicken).
• Sequence Length: 877
• Subcellular Localization: Nucleus . Chromosome, centromere . Chromosome . Cytoplasm, cytoskeleton, spindle . Midbody . Chromosome, centromere, kinetochore . Is restricted to the nucleus in interphase, remains tightly bound to the chromosomes until early metaphase, and during
• Protein Description: Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB toward substrates near microtubules. The flexibility of the SAH domain is proposed to allow AURKB to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin. Activates AURKB..
• Protein Sequence: MAVATGLARLPVVCNQRLAELLRQVDDVDLLWLEEIHEEAARMFGSHYSDQPELMPKTPSQKNRKRRKRPSALRGESLELGRRRLSRRRTNNLKAVSSKRDSQRLQNKEDTEGLGTEAQELSSQTVSRRLTRSQVAAPADRSEVLPEHLRERVVPVVEISVCDRISAEFQFQKCASERAENHSASLPPSSDDKSPKESSAAESQPLPAASELIVPHTPEAKGAGKNKSAFKKTANVADTTVVLSEKELGLEEVDDSAQVQKHNERDDKEPSQRTTDSPETPTGSRLSRRSVRRSLMGKPSTIRRTSLAEKYSLARKRESTIRKSIARTVIKRKAPQKLSVSSSSVNGSGSEEVPEDEETVVNAGPPPVPQTPPKLDFQGLRMSLRSQTVNRNEQQQETSNNECDLSKSEKTQEPPQSARRKTSYKRAVDQRYDTQQAEDGGLSPLRKKTPSPPCPASKVVRPFKTFLHTVEKNQLLMTPSSVGRNGVIKSFIKYNTPLQHDPKEKERQKLQALRKKEEAEQLRKQKVEEEKKRRQEEAKLRREERLRKVLQARERAEQLEEERKRRIEQKLALFDEKTEKAREERLAEEKIKKRAAAKKMEEAEARRRQDEEARKQKALQQEEEERRHKELMQKKKEEEQERARKIAEQRQAEQEREKQLAAEREQERKKEQERKKEEERIQAEKQREQQEKAARLQKEVLAAKEQLQKEMEKKEKEEQLLAEMKRQEQEQKKLPEEQKAKDVAQTQHLENKENSPACNSYQMTPQYHKDPKPPKINPNNYGMDLNSDDSTDDESQPRKPIPAWASGNQLSQAVIRQYYNPPNVDALFGTIVSPKLEDIFYKSKPRYFKRTSSAVWNSPPFPGAKSVLGLPYSLKKY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Oops, there are no PTM records of INCE_CHICK !!

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of INCE_CHICK !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of INCE_CHICK !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of INCE_CHICK !!

Protein-Protein Interaction

Oops, there are no PPI records of INCE_CHICK !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.