IMP2L_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IMP2L_HUMAN
• UniProt AC: Q96T52
• Protein Name: Mitochondrial inner membrane protease subunit 2
• Gene Name: IMMP2L
• Organism: Homo sapiens (Human).
• Sequence Length: 175
• Subcellular Localization: Mitochondrion inner membrane ; Single-pass membrane protein .
• Protein Description: Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO..
• Protein Sequence: MAQSQGWVKRYIKAFCKGFFVAVPVAVTFLDRVACVARVEGASMQPSLNPGGSQSSDVVLLNHWKVRNFEVHRGDIVSLVSPKNPEQKIIKRVIALEGDIVRTIGHKNRYVKVPRGHIWVEGDHHGHSFDSNSFGPVSLGLLHAHATHILWPPERWQKLESVLPPERLPVQREEE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
43	Phosphorylation	VARVEGASMQPSLNP EEEEECCCCCCCCCC	28.89	-
47	Phosphorylation	EGASMQPSLNPGGSQ ECCCCCCCCCCCCCC	24.72	-
81	Phosphorylation	GDIVSLVSPKNPEQK CCEEEEECCCCHHHH	35.14	24719451
83	Ubiquitination	IVSLVSPKNPEQKII EEEEECCCCHHHHHH	77.08	-
88	Ubiquitination	SPKNPEQKIIKRVIA CCCCHHHHHHHHHHH	44.74	-
112	Methylation	GHKNRYVKVPRGHIW CCCCCEEEECCCEEE	37.27	116253581

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IMP2L_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IMP2L_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IMP2L_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of IMP2L_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.