IMB4_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IMB4_SCHPO
• UniProt AC: O60100
• Protein Name: Probable importin subunit beta-4
• Gene Name: kap123
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 1067
• Subcellular Localization: Cytoplasm. Nucleus. Nucleus envelope.
• Protein Description: Required for nuclear protein import, its predominant substrate seems to be ribosomal proteins. Binds to nucleoporins and the GTP-bound form of gsp1 (Ran) (By similarity)..
• Protein Sequence: MDAQFTLELTQLLFQSIAPDTTQITEATRALETKYLKEPGSLLSLFHIMGTCENPQVRQLAAIEARKLCHKYWSSVDADVQNQIRSNLLDITLKEPESIVRHAFGRVIAALAKLDLPEGKWNELSAFLVQATMDQNDSIREMAVYVLYSIAETVDLDNKLLLDFVNLFSQTITDSSRTVRVTSVQGLGAIAEVLESDDKKLLHAYRATLPGMLLVLQDVVQVGDVDASKQVFDVFNTFLIASGAIISKALGNIIEIITGIANSKQVDDEIRCMALSFIISCIRFKSRKLQALKLGKPLVLTLMEVATEETTDDIDEDCPARLALRSIDLLSTHLSPSQVFYPMFEAACAFSQSPQASYRKAALLSIGVAVEGSSESVAGNLPNIFPIIINGLCDNDMDVRQAALLALSQIAVEIPTEVSKHHAQLLPLVFELMSTQGVKVGKSACNCIDALLEGLDKSEISGYLPMLMERLVGLLEFSDTPDIKSCVAAAIGSAAFAAQDDFIPYFERTMASLSQCLHTTDDDEGYELRGTVMDTLGAIANAVGKQAFLPYTEQLIQLAYEGIQIDHSRLRECSFCFYAVLARVYKEEFAPFLEHIVPALFKSIDQDESDILSERIGAPTAEEISQLLDSVETNEEENDEELEKAMGVNSAIAMEKEIAADALGEICMYVGAPFTPYLEPTVEKLVACTTHFYEGVRKSALSSLWRCATTYYKVCNVPQWQPGLPLKVPVPDTVKNIFEAVRKCTFDTLEEEYEKTVATDILRNFAESIKTCGPVVLGDDYEKLCEVVMEVLQKQHIVQAGDVFDDDFEEEDIVSNEEVDDTEQDALLIDSACDVVIALAVALGGSFADSFKVFYPQIVKYYMSKNGNERAMAVACVGEVAGGIESAITPFTRDVFSLFMAALEDSEGEVRSNAAYSMGLLCQFSTEDLSSEYLNILQKLQPFFTQEVFRTALDNAIGCISRLILHNQNAIPVDQVLPIVFSKLPLKEDYLENAPLYHMILALYRQQNPCLVQHLGELIPVFASVLTGSPEQLNDELRSELLSMVKEIAPQYESVVSNYPQLVALLQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
86	Phosphorylation	DVQNQIRSNLLDITL HHHHHHHHHCCCEEC	33.20	25720772
609	Phosphorylation	KSIDQDESDILSERI HCCCCCHHHHHHHHC	37.94	28889911
613	Phosphorylation	QDESDILSERIGAPT CCHHHHHHHHCCCCC	25.76	28889911
620	Phosphorylation	SERIGAPTAEEISQL HHHCCCCCHHHHHHH	46.28	29996109
625	Phosphorylation	APTAEEISQLLDSVE CCCHHHHHHHHHHHH	20.32	29996109
630	Phosphorylation	EISQLLDSVETNEEE HHHHHHHHHHCCHHH	23.09	25720772
633	Phosphorylation	QLLDSVETNEEENDE HHHHHHHCCHHHCHH	45.86	29996109

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IMB4_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IMB4_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IMB4_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IMB3_SCHPO	sal3	genetic	19818717

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.