| UniProt ID | ILKAP_MOUSE | |
|---|---|---|
| UniProt AC | Q8R0F6 | |
| Protein Name | Integrin-linked kinase-associated serine/threonine phosphatase 2C | |
| Gene Name | Ilkap | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 392 | |
| Subcellular Localization | Cytoplasm. | |
| Protein Description | Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation (By similarity).. | |
| Protein Sequence | MDLFGDLPEPERAPRPSAGKEAQGRPVLFEDLPPASSTDSGSGGPLLFDDLPPAASGNSGSLATSGSQVVKTEGKGAKRKAPEEEKNGGEELVEKKVCKASSVIFGLKGYVAERKGEREEMQDAHVILNDITQECNPPSSLITRVSYFAVFDGHGGIRASKFAAQNLHQNLIRKFPKGDIISVEKTVKRCLLDTFKHTDEEFLKQASSQKPAWKDGSTATCVLAVDNILYIANLGDSRAILCRYNEESQKHAALSLSKEHNPTQYEERMRIQKAGGNVRDGRVLGVLEVSRSIGDGQYKRCGVTSVPDIRRCQLTPNDRFILLACDGLFKVFTPEEAVNFILSCLEDDKIQTREGKPAVDARYEAACNRLANKAVQRGSADNVTVMVVRIGH | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 1 | Acetylation | -------MDLFGDLP -------CCCCCCCC | 10.23 | - | |
| 17 | Phosphorylation | PERAPRPSAGKEAQG CCCCCCCCCCCCCCC | 51.43 | 25266776 | |
| 20 | Acetylation | APRPSAGKEAQGRPV CCCCCCCCCCCCCCC | 49.98 | 155435 | |
| 41 | Ubiquitination | PASSTDSGSGGPLLF CCCCCCCCCCCCEEC | 32.87 | 27667366 | |
| 133 | Ubiquitination | VILNDITQECNPPSS EEHHHHHHHCCCCCH | 54.29 | 27667366 | |
| 139 | Ubiquitination | TQECNPPSSLITRVS HHHCCCCCHHEEEEE | 38.75 | 27667366 | |
| 153 | Ubiquitination | SYFAVFDGHGGIRAS EEEEEECCCCCHHHH | 15.18 | 27667366 | |
| 155 | Ubiquitination | FAVFDGHGGIRASKF EEEECCCCCHHHHHH | 38.46 | 27667366 | |
| 161 | Ubiquitination | HGGIRASKFAAQNLH CCCHHHHHHHHHHHH | 37.73 | 22790023 | |
| 185 | Acetylation | GDIISVEKTVKRCLL CCCEEEHHHHHHHHH | 57.36 | 22826441 | |
| 210 | Acetylation | LKQASSQKPAWKDGS HHHHHHCCCCCCCCC | 38.35 | - | |
| 253 | Ubiquitination | EESQKHAALSLSKEH HHHHHHHHHHHCCCC | 9.45 | 27667366 | |
| 303 | Ubiquitination | GQYKRCGVTSVPDIR CCCEECCCCCCCCCC | 4.06 | 27667366 | |
| 305 | Phosphorylation | YKRCGVTSVPDIRRC CEECCCCCCCCCCCC | 29.28 | 29899451 | |
| 345 | Ubiquitination | VNFILSCLEDDKIQT HHHHHHHHHCCCCCC | 7.90 | 27667366 | |
| 351 | Ubiquitination | CLEDDKIQTREGKPA HHHCCCCCCCCCCCC | 40.00 | 27667366 | |
| 365 | Ubiquitination | AVDARYEAACNRLAN CCHHHHHHHHHHHHH | 14.37 | 27667366 | |
| 367 | Ubiquitination | DARYEAACNRLANKA HHHHHHHHHHHHHHH | 3.82 | 27667366 | |
| 373 | Ubiquitination | ACNRLANKAVQRGSA HHHHHHHHHHHCCCC | 44.31 | 27667366 | |
| 373 | Malonylation | ACNRLANKAVQRGSA HHHHHHHHHHHCCCC | 44.31 | 26320211 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ILKAP_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ILKAP_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ILKAP_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of ILKAP_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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