ILF2_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ILF2_RAT
• UniProt AC: Q7TP98
• Protein Name: Interleukin enhancer-binding factor 2
• Gene Name: Ilf2
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 463
• Subcellular Localization: Nucleus, nucleolus. Cytoplasm. Nucleus. Localized in cytoplasmic mRNP granules containing untranslated mRNAs..
• Protein Description: Appears to function predominantly as a heterodimeric complex with ILF3. This complex may regulate transcription of the IL2 gene during T-cell activation. It can also promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA (By similarity). Essential for the efficient reshuttling of ILF3 into the nucleus (By similarity)..
• Protein Sequence: MVSTHLTSTTLPDCYRSLIVNSELGSSALMDLNSPSFLYPLLHTPADKGTLCTYQAALGKVYASLEVIGVGDDKLQAVHGLNGGKPHRDILGSRITRPTGIKPLCLPRHILAYDWLAQSLLGIVIGSISLAYNELLMMEKLKGFRPFVPHIPFDFYLCEMAFPRVKPAPDETSFSEALLKRNQDLAPNSAEQQIEEVRQVGSYKKGTMTTGHNVADLVVILKILPTFLTMLTNETGFEISSSDATVKILITTVPPNLRKLDPELHLDIKVLQSALAAIRHARWFEENASQSTVKVLIRLLKDLRIRFPGFEPLTPWILDLLGHYAVMNNPTRQPLALNVAYRRCLQILAAGLFLPGSVGITDPCESGNFRVHTVMTLEQQDMVCYTAQTLVRILSHGGFRKILGQEGDASYLASEISTWDGVIVTPSEKAYEKPPEKKEGEEEEENTEEPPQGEEEESMETQE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
94	Asymmetric dimethylarginine	HRDILGSRITRPTGI CHHHCCCCCCCCCCC	32.28	-
94	Methylation	HRDILGSRITRPTGI CHHHCCCCCCCCCCC	32.28	-
145	Methylation	MEKLKGFRPFVPHIP HHHHCCCCCCCCCCC	32.20	-
166	Ubiquitination	EMAFPRVKPAPDETS HHHCCCCCCCCCCCC	36.42	-
172	Phosphorylation	VKPAPDETSFSEALL CCCCCCCCCHHHHHH	42.31	23984901
173	Phosphorylation	KPAPDETSFSEALLK CCCCCCCCHHHHHHH	25.40	23984901
175	Phosphorylation	APDETSFSEALLKRN CCCCCCHHHHHHHHC	23.02	23984901
189	Phosphorylation	NQDLAPNSAEQQIEE CCCCCCCCHHHHHHH	31.93	-
289	Phosphorylation	RWFEENASQSTVKVL HHHHHCCCHHHHHHH	35.92	27097102
291	Phosphorylation	FEENASQSTVKVLIR HHHCCCHHHHHHHHH	32.45	27097102
292	Phosphorylation	EENASQSTVKVLIRL HHCCCHHHHHHHHHH	19.40	27097102
461	Phosphorylation	EEEESMETQE----- CHHHHHCCCC-----	29.38	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ILF2_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ILF2_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ILF2_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of ILF2_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.