dbPTM

IKKE1_CAEEL - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	IKKE1_CAEEL
UniProt AC	P32742
Protein Name	Inhibitor of nuclear factor kappa-B kinase epsilon subunit homolog 1 {ECO:0000312\|WormBase:R107.4b}
Gene Name	ikke-1 {ECO:0000312\|WormBase:R107.4b}
Organism	Caenorhabditis elegans.
Sequence Length	820
Subcellular Localization	Cytoplasm . Localizes to cytoplasmic puncta in oocytes. After fertilization, localizes to paternal organelles during meiosis I and meiosis II. Co-localizes with allo-1 in embryos and oocytes.
Protein Description	Serine/threonine-protein kinase, which plays a role in regulating allophagy, an autophagic process in which paternal organelles, including mitochondria and membranous organelles, are degraded in embryos. Phosphorylates the allophagy receptor allo-1, which is required for allophagy..
Protein Sequence	MAVSPHKTYPIVITHGEKYTLFNDESIGKGAYSEVYRGRTESGRLVAVKTACKKLEVAAIGIEIEILKKLKGASNIVQYFGSNHTKMAPGSVTSETISFAMEYASSSLEAEMRRPKNHRGLSSNALIDLVVDCSMALSALREHNIAHRDIKHMNILLFPGTPTRGRRSTHLFKLCDMGCSKSLSENSSHEMRTLVGTPNLLHPFLAHEMVDPLMAQNRHNWKTKSAYTSEQCDLWALGCTLYFCATGKFPFEHERNNKSLYHKAVVALTQNPDAIAMVLVQKGRDPGRRTDIFEFQPVTELPAKFTRYPKWLVSTMTCLLRSFFHEPSIEYYAKVADAMRNSKRRTFSSVDQMSIVEHTDMSNVPHLGFSIPSISKCLGYPEGTDILLLSNTSTHYLDSKQKSVDGLPDDLYLVVPQTSHVDMRKILARNIEFHEFDDMTDRKLSEIRIKKCYEGLSMLTEIDEYLALFDRVSTILSTQFSLLVQELSQFERVQTASRFAVYVDMASVPLMLFDEANPETKMISDQCIQQAKRAREELERHAKVSMDIEACAKQLSKDAEDLRLEDMDLPGICEEIESYVFYDKQAILSTQKYSQELVELCLKRRNNIMEQIFNSPDRINKSKLNKAMNLAASLSQLRSNYRKLQDMISECVDLLEKPFQEMKDTVNRYLQAQGCSRNTMQKSMHLLRPEFHESQIRIKKTTKSCRKLIDQLNIELDQLGFVRLGDILIKAESEQTLTRSEEIQETQVVSFFCQAESSPNKEQFPKPEQDSILESSIDEGSTSFESTPPSSPPDVGSNNYFQAVFQYFAKPTSSPSSSAK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
649	Phosphorylation	RKLQDMISECVDLLE HHHHHHHHHHHHHHH	20.50	28854356

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of IKKE1_CAEEL !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of IKKE1_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of IKKE1_CAEEL !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of IKKE1_CAEEL !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of IKKE1_CAEEL

Related Literatures of Post-Translational Modification