IKIP_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IKIP_RAT
• UniProt AC: Q5EAJ6
• Protein Name: Inhibitor of nuclear factor kappa-B kinase-interacting protein
• Gene Name: Ikbip
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 373
• Subcellular Localization: Endoplasmic reticulum membrane; Single-pass membrane protein.
• Protein Description: Target of p53/TP53 with pro-apoptotic function..
• Protein Sequence: MSEVKSRKKPGPKVAAPEPEKRSDGRKNPEARGGAGWADPRTGLSLLSLATSLGLAWLVFQQSEKFAKVENQYRLLQTESSEFQGLQSKISLISNKLESTENTLQEATSSMSLMTQFEQEVAGLQRSIHDIENSEEMLTQKLQNLNEKFQNITDLWKRTLVEMSDNTAVFKSEAKSTHSEVTLKINSAEQEIKLLTERLKDLEDSTLRNIRTVSRQEEEDLLRVEAQLSSDTKAVEKLEEEQRTLLARDEDLTDKLSSYEPKVEECKAHLPTIENAVHSVLRVSQDLIGTERKMEELTVQMFNMEDDMLKAVSEIMEMQNTLEGIQYDNSLLKMQNELVVLKGKVHDFMAYSSAGEKGTLEEYNLENKGTDDY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	Ubiquitination	VAAPEPEKRSDGRKN CCCCCCCCCCCCCCC	68.84	-
78	Phosphorylation	NQYRLLQTESSEFQG HHHHHHHCCCHHHHH	37.49	22108457
151	N-linked_Glycosylation	NLNEKFQNITDLWKR HHHHHHHHHHHHHHH	42.11	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IKIP_RAT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
151	N	Glycosylation	N-glycosylated at Asn-151.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IKIP_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of IKIP_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.