IKBZ_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IKBZ_MOUSE
• UniProt AC: Q9EST8
• Protein Name: NF-kappa-B inhibitor zeta
• Gene Name: Nfkbiz
• Organism: Mus musculus (Mouse).
• Sequence Length: 728
• Subcellular Localization: Nucleus .
• Protein Description: Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Seems also to activate NF-kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS. Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling. May promote apoptosis (By similarity). Involved in the induction of T helper 17 cells (Th17) differentiation upon recognition of antigen by T cell antigen receptor (TCR). [PubMed: 25282160]
• Protein Sequence: MIVDKLLDDSRGGEGLLDAAGDCGLMTSPLNLAYFYGASPPSAPGAGDTGYLSAVPSAPGSPGSDSSDFSSTSSVSSCGAVESRPRGGARAERPQVEPHMGVGRQQRGPFQGVRVKNSVKELLLHIRSNKQKASGQPVDEFKTQSVNIEQLTDLKSAVSAVGKRKGPDPLSDGPVCKRPALLPSHFVTSPQTPTPGESMEDVRHSESKLDSSAALLQNIINIKNECNPVSLNTVQVSWMSPTVPQNSPRDQCQDFHGGQAFSPPQKYQPFQVSGSPQMMDQASMYQYSPQTQNMQQPPPLPPQQQHQQNYPHNSPLQFSPYSRMSQSPKYDSNLFDTHEPQFCTGQSFVSLLTGPGEPESLAVPVPAPTSIPPQTETQLQTFSLMPSNACEAVVGVHDVGSHSLGTSLSLQNIMGSPMNTTQLGKSFFQWQVEQEESKLANIPQDQFLARDGDGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNLGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVRSNQFVDLEATNYDGLTPLHCAVVAHNAVVHELQRNRQSHSPEVQDLLLRNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRVTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGKSIQQRAPPY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
134	Phosphorylation	RSNKQKASGQPVDEF HCCCCCCCCCCCCCH	45.02	21454597
189	Phosphorylation	LPSHFVTSPQTPTPG CCCCCCCCCCCCCCC	15.09	22942356
192	Phosphorylation	HFVTSPQTPTPGESM CCCCCCCCCCCCCCH	32.30	22942356
240	Phosphorylation	TVQVSWMSPTVPQNS EEEEEEECCCCCCCC	15.91	22942356
247	Phosphorylation	SPTVPQNSPRDQCQD CCCCCCCCCCHHCCC	18.96	22942356
262	Phosphorylation	FHGGQAFSPPQKYQP CCCCCCCCCCCCCCC	38.39	23459991
544	Acetylation	QVLQAIQKGAVRSNQ HHHHHHHHCCCCCCC	42.60	15614257
586	Phosphorylation	ELQRNRQSHSPEVQD HHHHHHHCCCHHHHH	23.77	26643407
588	Phosphorylation	QRNRQSHSPEVQDLL HHHHHCCCHHHHHHH	28.18	26643407
600	Phosphorylation	DLLLRNKSLVDTIKC HHHHCCHHHHHHHHH	36.85	-
604	Phosphorylation	RNKSLVDTIKCLIQM CCHHHHHHHHHHHHC	18.17	-
674	Phosphorylation	ASLQYRVTQLDAVRL HHCHHCHHHHHHHHH	17.89	21659605
717	Acetylation	EQIRRILKGKSIQQR HHHHHHHCCCCHHHC	63.02	-
719	Acetylation	IRRILKGKSIQQRAP HHHHHCCCCHHHCCC	42.68	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IKBZ_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IKBZ_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IKBZ_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of IKBZ_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.