IKBZ_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IKBZ_HUMAN
• UniProt AC: Q9BYH8
• Protein Name: NF-kappa-B inhibitor zeta
• Gene Name: NFKBIZ
• Organism: Homo sapiens (Human).
• Sequence Length: 718
• Subcellular Localization: Nucleus . Aggregated in dot-like structures. Colocalizes with NCOR2.
• Protein Description: Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Seems also to activate NF-kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS. Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling. May promote apoptosis (By similarity). Involved in the induction of T helper 17 cells (Th17) differentiation upon recognition of antigen by T cell antigen receptor (TCR) (By similarity)..
• Protein Sequence: MIVDKLLDDSRGGEGLRDAAGGCGLMTSPLNLSYFYGASPPAAAPGACDASCSVLGPSAPGSPGSDSSDFSSASSVSSCGAVESRSRGGARAERQPVEPHMGVGRQQRGPFQGVRVKNSVKELLLHIRSHKQKASGQAVDDFKTQGVNIEQFRELKNTVSYSGKRKGPDSLSDGPACKRPALLHSQFLTPPQTPTPGESMEDVHLNEPKQESSADLLQNIINIKNECSPVSLNTVQVSWLNPVVVPQSSPAEQCQDFHGGQVFSPPQKCQPFQVRGSQQMIDQASLYQYSPQNQHVEQQPHYTHKPTLEYSPFPIPPQSPAYEPNLFDGPESQFCPNQSLVSLLGDQRESENIANPMQTSSSVQQQNDAHLHSFSMMPSSACEAMVGHEMASDSSNTSLPFSNMGNPMNTTQLGKSLFQWQVEQEESKLANISQDQFLSKDADGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNIGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVGSNQFVDLEATNYDGLTPLHCAVIAHNAVVHELQRNQQPHSPEVQELLLKNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRLTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGKSIQQRAPPY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	VDKLLDDSRGGEGLR CCCCCCCCCCCCCHH	32.27	24505115
56	Ubiquitination	DASCSVLGPSAPGSP CCCCEECCCCCCCCC	16.38	29967540
156	Ubiquitination	IEQFRELKNTVSYSG HHHHHHHHCCCCCCC	45.91	29967540
158	Phosphorylation	QFRELKNTVSYSGKR HHHHHHCCCCCCCCC	14.83	29083192
160	Phosphorylation	RELKNTVSYSGKRKG HHHHCCCCCCCCCCC	16.14	29083192
161	Phosphorylation	ELKNTVSYSGKRKGP HHHCCCCCCCCCCCC	19.67	29083192
162	Phosphorylation	LKNTVSYSGKRKGPD HHCCCCCCCCCCCCC	30.27	29083192
170	Phosphorylation	GKRKGPDSLSDGPAC CCCCCCCCCCCCCCC	32.67	-
172	Phosphorylation	RKGPDSLSDGPACKR CCCCCCCCCCCCCCC	44.46	-
189	Phosphorylation	LLHSQFLTPPQTPTP HHCCCCCCCCCCCCC	33.92	24719451
193	Phosphorylation	QFLTPPQTPTPGESM CCCCCCCCCCCCCCH	34.60	24719451
661	Phosphorylation	HVAASLQYRLTQLDA HHHHHHHHHHHHHHH	16.94	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IKBZ_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IKBZ_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IKBZ_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NFKB1_HUMAN	NFKB1	physical	11356851
STAT3_HUMAN	STAT3	physical	19595668
STAT3_HUMAN	STAT3	physical	21988832

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.