IKBP1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IKBP1_HUMAN
• UniProt AC: Q5VVH5
• Protein Name: Interleukin-1 receptor-associated kinase 1-binding protein 1
• Gene Name: IRAK1BP1
• Organism: Homo sapiens (Human).
• Sequence Length: 260
• Subcellular Localization: Cytoplasm. Nucleus.
• Protein Description: Component of the IRAK1-dependent TNFRSF1A signaling pathway that leads to NF-kappa-B activation and is required for cell survival. Acts by enhancing RELA transcriptional activity (By similarity)..
• Protein Sequence: MSLQKTPPTRVFVELVPWADRSRENNLASGRETLPGLRHPLSSTQAQTATREVQVSGTSEVSAGPDRAQVVVRVSSTKEAAAEAKKSVCRRLDYITQSLQQQGVQAENITVTKDFRRVENAYHMEAEVCITFTEFGKMQNICNFLVEKLDSSVVISPPQFYHTPGSVENLRRQACLVAVENAWRKAQEVCNLVGQTLGKPLLIKEEETKEWEGQIDDHQSSRLSSSLTVQQKIKSATIHAASKVFITFEVKGKEKRKKHL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Ubiquitination	---MSLQKTPPTRVF ---CCCCCCCCCEEE	69.19	-
56	Phosphorylation	ATREVQVSGTSEVSA CEEEEEECCCCEECC	21.18	-
62	Phosphorylation	VSGTSEVSAGPDRAQ ECCCCEECCCCCCEE	24.37	-
122	Phosphorylation	FRRVENAYHMEAEVC HHHHHHHHCCCEEEE	17.18	-
235	Phosphorylation	TVQQKIKSATIHAAS CHHHHHHHCHHEECC	33.83	-
237	Phosphorylation	QQKIKSATIHAASKV HHHHHHCHHEECCEE	22.01	-
242	Phosphorylation	SATIHAASKVFITFE HCHHEECCEEEEEEE	30.09	-
247	Phosphorylation	AASKVFITFEVKGKE ECCEEEEEEEECCHH	11.41	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IKBP1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
56	S	Phosphorylation	Phosphorylation at Ser-56 and/or Ser-62 is required for full activity.	-
62	S	Phosphorylation	Phosphorylation at Ser-56 and/or Ser-62 is required for full activity.	-
235	S	Phosphorylation	Phosphorylated on at least one of Ser-235, Thr-237, Ser-242 and Thr-247 upon TNF-alpha activation, which favors nuclear translocation (By similarity).	-
237	T	Phosphorylation	Phosphorylated on at least one of Ser-235, Thr-237, Ser-242 and Thr-247 upon TNF-alpha activation, which favors nuclear translocation (By similarity).	-
242	S	Phosphorylation	Phosphorylated on at least one of Ser-235, Thr-237, Ser-242 and Thr-247 upon TNF-alpha activation, which favors nuclear translocation (By similarity).	-
247	T	Phosphorylation	Phosphorylated on at least one of Ser-235, Thr-237, Ser-242 and Thr-247 upon TNF-alpha activation, which favors nuclear translocation (By similarity).	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IKBP1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of IKBP1_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.