IFI2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IFI2_MOUSE
• UniProt AC: Q9R002
• Protein Name: Interferon-activable protein 202
• Gene Name: Ifi202
• Organism: Mus musculus (Mouse).
• Sequence Length: 445
• Subcellular Localization: Cytoplasm . Nucleus . Accumulates first in the cytoplasm, and is translocated to the nucleus after a delay, where it is primarily chromatin-associated.
• Protein Description: Inhibits the transcriptional activity of several transcription factors, including NF-kappa-B p50 and p65, FOS, JUN, E2F1, E2F4, MYOD1 and myogenin. Has anti-apoptotic effects due to inhibition of the transcriptional activity of p53. Binds dsDNA in the cytosol. Is involved in innate immune response and has anti-inflammatory activity. Inhibits caspase activation in response to cytosolic DNA and inhibits the activation of the AIM2 inflammasome, probably by sequestering cytoplasmic DNA and preventing its being bound by AIM2..
• Protein Sequence: MSNRNLRSSTNSEFSEGQHQTPSSDSSGHGEDQPQASPGPNKKSHTPKKNISKGAVLHEKPMTVMVLTATEPFNYKEGKENMFHATVATESQYYRVKVFNMDLKEKFTENKFITISKYFNSSGILEINETATVSEAAPNQIIEVPKNIIRSAKETLKISKIKELDSGTLIYGVFAVEKKKVNDKSITFKIKDNEDNIKVVWDKKQHNINYEKGDKLQLFSFHLRKGNGKPILHSGNHSFIKGEKLLKESFEGDGYHKGPKQVVALKATKLFTYDSIKSKKMFHATVATDTEFFRVMVFEENLEKKFIPGNTIALSDYFGMYGSLAIHEYSSVSEVKSQNKEDSSSSDERLIEHLKICDLHLQTKERLVDGEFKVYRKSTGNNCICYGIWDDTGAMKVVVSGQLTSVNCEIGNTIRLVCFELTSNADEWFLRSTRYSYMEVIMPEK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MSNRNLRSSTNSEFS CCCCCCCCCCCCCCC	44.68	25777480
9	Phosphorylation	SNRNLRSSTNSEFSE CCCCCCCCCCCCCCC	25.77	25777480
10	Phosphorylation	NRNLRSSTNSEFSEG CCCCCCCCCCCCCCC	43.97	25777480
12	Phosphorylation	NLRSSTNSEFSEGQH CCCCCCCCCCCCCCC	39.86	25777480
15	Phosphorylation	SSTNSEFSEGQHQTP CCCCCCCCCCCCCCC	36.44	25777480
21	Phosphorylation	FSEGQHQTPSSDSSG CCCCCCCCCCCCCCC	24.02	25777480
23	Phosphorylation	EGQHQTPSSDSSGHG CCCCCCCCCCCCCCC	50.60	25777480
24	Phosphorylation	GQHQTPSSDSSGHGE CCCCCCCCCCCCCCC	42.59	25777480
26	Phosphorylation	HQTPSSDSSGHGEDQ CCCCCCCCCCCCCCC	39.92	25777480
27	Phosphorylation	QTPSSDSSGHGEDQP CCCCCCCCCCCCCCC	39.54	25777480
37	Phosphorylation	GEDQPQASPGPNKKS CCCCCCCCCCCCCCC	25.74	23684622
46	Phosphorylation	GPNKKSHTPKKNISK CCCCCCCCCCCCCCC	43.84	24719451
86	Phosphorylation	KENMFHATVATESQY CCCCCEEEEECCCCE	11.34	25293948
89	Phosphorylation	MFHATVATESQYYRV CCEEEEECCCCEEEE	31.65	25293948
91	Phosphorylation	HATVATESQYYRVKV EEEEECCCCEEEEEE	21.09	25293948
93	Phosphorylation	TVATESQYYRVKVFN EEECCCCEEEEEEEC	11.52	25293948
94	Phosphorylation	VATESQYYRVKVFNM EECCCCEEEEEEECC	10.99	25293948
268	Phosphorylation	QVVALKATKLFTYDS HEEEEEEEECCCHHH	27.05	22817900
272	Phosphorylation	LKATKLFTYDSIKSK EEEEECCCHHHHCCC	36.53	22817900
275	Phosphorylation	TKLFTYDSIKSKKMF EECCCHHHHCCCCEE	22.85	24719451
278	Phosphorylation	FTYDSIKSKKMFHAT CCHHHHCCCCEEEEE	35.52	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IFI2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IFI2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IFI2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of IFI2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.