IFC2_CAEEL - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IFC2_CAEEL
• UniProt AC: Q21067
• Protein Name: Intermediate filament protein ifc-2
• Gene Name: ifc-2
• Organism: Caenorhabditis elegans.
• Sequence Length: 622
• Subcellular Localization: Cytoplasm .
• Protein Description: Cytoplasmic intermediate filaments provide mechanical strength to cells. Not essential protein, although its absence leads to mild defects in locomotion..
• Protein Sequence: MSTYAAYTTSTYQGRGLASGTYASGFGQLVSGMSSAGAICTTQIRDAREREKREIGLLNDRLADYIEKVRFLEAQNRCLSHDIDILRNGFSGGGHVSGLFDAEINQAKHILEQTTAHRSTFERDITGLSAEIEVFRKKWLDAVNAVKAHREDHDVDLDRLAKIEAEISLFKRKIRIVEEDVIRIRRENDGIYNEIARIKQLTHNEIALKNERSLNVSDLLQRINLLQTENNVRIEQELVFIRRDTTADNRDYFRHELQAAIRDIRADYEAISIRNRQDIEVWYREQIRKIQDESVRVNPDLYKEELISIRTTVTNVRSRLAEVEGRNFFLERLIDDLKNNEEAKFFEISLAERDAQIATLRDQCTELSIQMEKLCDNEISLRAEIERYRILLNGANVTTYTSNTHGSGSGIAVGGVVGGSTRVISQTTRTHSSSNTSYSNVPASRGGYSISGNVGGISVGGTIGSHGASAHATGGIIGSGVQAHRGSVSSLITDKPRDRVHDEKGVDQSGRHFHSWYLGTISINQVTPSYIELKNICKIRRVDVGGFRIEQSVNGQVLGSAQINVPLILDPQEVVRFNHRHGKYLGQFFMDVDAFDNSTVARTSMYNYTEPHEERAWFVYLD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MSTYAAYTTSTYQG -CCCEEEEECCCCCC	11.46	27067626
19	Phosphorylation	YQGRGLASGTYASGF CCCCCCCCCCCCCCC	36.39	30078680
21	Phosphorylation	GRGLASGTYASGFGQ CCCCCCCCCCCCCHH	17.26	19060867
22	Phosphorylation	RGLASGTYASGFGQL CCCCCCCCCCCCHHH	11.42	30078680
24	Phosphorylation	LASGTYASGFGQLVS CCCCCCCCCCHHHHC	25.00	19060867
31	Phosphorylation	SGFGQLVSGMSSAGA CCCHHHHCCCCCCCC	37.05	19060867
34	Phosphorylation	GQLVSGMSSAGAICT HHHHCCCCCCCCEEH	22.14	19060867
35	Phosphorylation	QLVSGMSSAGAICTT HHHCCCCCCCCEEHH	23.10	19060867
41	Phosphorylation	SSAGAICTTQIRDAR CCCCCEEHHHHHHHH	18.67	19530675
42	Phosphorylation	SAGAICTTQIRDARE CCCCEEHHHHHHHHH	20.00	18806794
294	Phosphorylation	IRKIQDESVRVNPDL HHHHCCCCCCCCHHH	24.42	30078680
425	Phosphorylation	GGSTRVISQTTRTHS CCCEEEEEEEEECCC	20.72	19530675
427	Phosphorylation	STRVISQTTRTHSSS CEEEEEEEEECCCCC	16.08	19530675
428	Phosphorylation	TRVISQTTRTHSSSN EEEEEEEEECCCCCC	26.40	19530675
430	Phosphorylation	VISQTTRTHSSSNTS EEEEEEECCCCCCCC	24.82	19060867
432	Phosphorylation	SQTTRTHSSSNTSYS EEEEECCCCCCCCCC	34.54	19060867
433	Phosphorylation	QTTRTHSSSNTSYSN EEEECCCCCCCCCCC	21.72	21082442
434	Phosphorylation	TTRTHSSSNTSYSNV EEECCCCCCCCCCCC	47.33	21082442
436	Phosphorylation	RTHSSSNTSYSNVPA ECCCCCCCCCCCCCH	30.87	19060867
437	Phosphorylation	THSSSNTSYSNVPAS CCCCCCCCCCCCCHH	30.71	21082442
438	Phosphorylation	HSSSNTSYSNVPASR CCCCCCCCCCCCHHH	11.39	27067626
487	Phosphorylation	GVQAHRGSVSSLITD CCCCCCCCHHHHCCC	20.84	19060867
487 (in isoform 2)	Phosphorylation	-	20.84	19530675
489	Phosphorylation	QAHRGSVSSLITDKP CCCCCCHHHHCCCCC	22.56	30078680
489 (in isoform 2)	Phosphorylation	-	22.56	19530675
490	Phosphorylation	AHRGSVSSLITDKPR CCCCCHHHHCCCCCC	22.95	30078680
490 (in isoform 2)	Phosphorylation	-	22.95	19530675
493 (in isoform 2)	Phosphorylation	-	43.17	19530675
493	Phosphorylation	GSVSSLITDKPRDRV CCHHHHCCCCCCCCC	43.17	19530675
496 (in isoform 2)	Phosphorylation	-	46.33	19530675
498 (in isoform 2)	Phosphorylation	-	66.53	19530675
500 (in isoform 2)	Phosphorylation	-	8.59	19530675

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IFC2_CAEEL !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IFC2_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IFC2_CAEEL !!

Protein-Protein Interaction

Oops, there are no PPI records of IFC2_CAEEL !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.