IFB1_CAEEL - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IFB1_CAEEL
• UniProt AC: Q19289
• Protein Name: Intermediate filament protein ifb-1
• Gene Name: ifb-1
• Organism: Caenorhabditis elegans.
• Sequence Length: 589
• Subcellular Localization: Cytoplasm.
• Protein Description: Cytoplasmic intermediate filaments provide mechanical strength to cells. Essential protein, involved in attachment structures in epidermal cells that connect muscles to the external cuticle. Required in morphogenesis and epidermal integrity. Probable component of embryonic epidermal attachment structures. Functions in larval muscle attachment independently of ifa-2..
• Protein Sequence: MSSHKESSEYEMQYRSTIQPRTAVRSQSRQSGNYVSGGNGAGSGGRVLKMVTEMGSATVGGISPALSANAAKSFLEATDKEKKTLQGLNDRLGNYIDRVKKLEEQNRKLVADLDELRGKWGKDTSEIKIKYSESLSTARKDIDDAARRKAEVDVKVARHRDDLAEYRSRYEDIQQRRESDREKISQWTNAIADAQSEVEMLRARFKQLTDEEKRVTADNSRIWEELQKARSDLDDETIGRIDFQNQVQTLMEELEFLRRVHEQEVKELQALLAQAPADTREFFKNELALAIRDIKDEYDIIAKQGKQDMESWYKLKVSEVQGSANRANMESTYQRDEVKRMRDNIGDLRGKLGDLENKNSLLEKEVQNLNYQLTDDQRQYEAALNDRDATLRRMREECQTLVAELQALLDTKQMLDAEIAIYRKMLEGEETRVGLTQMVEQAVKTHSLQQQENTDSTRSVRGEVSTKTTFQRSAKGNVTISECDPNGKFIKLENSHRNKDENVGEHKIRRKLDGRREIVYSIPANVVIKPGKNLTIYARDQGGINNPPESLVFDGENTWGIGANVVTSLVNKDGEERATHTQKTIQSGQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSSHKESSE ------CCCCCCCCC	40.94	18806794
3	Phosphorylation	-----MSSHKESSEY -----CCCCCCCCCH	36.96	19530675
7	Phosphorylation	-MSSHKESSEYEMQY -CCCCCCCCCHHHHH	33.02	30078680
8	Phosphorylation	MSSHKESSEYEMQYR CCCCCCCCCHHHHHH	45.34	18806794
10	Phosphorylation	SHKESSEYEMQYRST CCCCCCCHHHHHHCC	20.74	19530675
12 (in isoform 2)	Phosphorylation	-	4.09	19530675
26	Phosphorylation	QPRTAVRSQSRQSGN CCCCHHHCCCCCCCC	26.38	18806794
28	Phosphorylation	RTAVRSQSRQSGNYV CCHHHCCCCCCCCCC	33.27	19530675
31	Phosphorylation	VRSQSRQSGNYVSGG HHCCCCCCCCCCCCC	28.09	19060867
34	Phosphorylation	QSRQSGNYVSGGNGA CCCCCCCCCCCCCCC	10.26	21082442
36	Phosphorylation	RQSGNYVSGGNGAGS CCCCCCCCCCCCCCC	30.53	18806794
43	Phosphorylation	SGGNGAGSGGRVLKM CCCCCCCCHHHHHHH	37.22	19060867
56	Phosphorylation	KMVTEMGSATVGGIS HHEEECCCCEECCCC	21.32	30078680
58	Phosphorylation	VTEMGSATVGGISPA EEECCCCEECCCCHH	22.75	30078680
63	Phosphorylation	SATVGGISPALSANA CCEECCCCHHHCHHH	13.85	28854356
67	Phosphorylation	GGISPALSANAAKSF CCCCHHHCHHHHHHH	22.91	28854356
134	Phosphorylation	IKIKYSESLSTARKD HEEEECCHHHHHHHC	22.98	28854356
136	Phosphorylation	IKYSESLSTARKDID EEECCHHHHHHHCHH	29.33	19530675
137	Phosphorylation	KYSESLSTARKDIDD EECCHHHHHHHCHHH	35.46	19530675
166	Phosphorylation	HRDDLAEYRSRYEDI CHHHHHHHHHHHHHH	14.31	27067626
216	Phosphorylation	TDEEKRVTADNSRIW CHHHHHHCCCHHHHH	32.12	19530675
231	Phosphorylation	EELQKARSDLDDETI HHHHHHHHCCCCCCH	47.59	28854356
360	Phosphorylation	GDLENKNSLLEKEVQ HCCCCCCHHHHHHHH	35.62	19530675
390	Phosphorylation	ALNDRDATLRRMREE HHCCHHHHHHHHHHH	25.70	19530675
445	Phosphorylation	MVEQAVKTHSLQQQE HHHHHHHHCCCCCHH	15.31	19530675
447	Phosphorylation	EQAVKTHSLQQQENT HHHHHHCCCCCHHCC	32.86	19060867
456	Phosphorylation	QQQENTDSTRSVRGE CCHHCCCCCHHHCCE	24.55	21082442
460 (in isoform 2)	Sumoylation	-	9.09	-
491	Sumoylation	DPNGKFIKLENSHRN CCCCCEEEEECCCCC	53.53	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IFB1_CAEEL !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IFB1_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IFB1_CAEEL !!

Protein-Protein Interaction

Oops, there are no PPI records of IFB1_CAEEL !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.