IFA2_CAEEL - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IFA2_CAEEL
• UniProt AC: O02365
• Protein Name: Intermediate filament protein ifa-2
• Gene Name: mua-6 {ECO:0000312|WormBase:W10G6.3}
• Organism: Caenorhabditis elegans.
• Sequence Length: 581
• Subcellular Localization: Cell junction, hemidesmosome . Colocalizes with myoactin.
• Protein Description: Cytoplasmic intermediate filaments provide mechanical strength to cells. Essential protein, involved in attachment structures in epidermal cells that connect muscles to the external cuticle. Probably acts by forming hypodermal hemidesmosome complexes that help mediate muscle-cuticle force transduction. Although expressed during embryogenesis, it is not required for embryonic development of muscle-cuticle linkages nor for the localization of other proteins to the hemidesmosomes in embryos..
• Protein Sequence: MTDPDSYRSSITSRPSFNRTVTSSSQNYGAPGSGNRVLKIVTETHSSSVSSGLSPYGQNAASTIRDNREREKKEIMELNDRLASYIEKVRFLDAQNRKLDADLKMLQGRFGKSTGSVKVMYEMEITTATNVVKQTGKDHGETEKEIRKLQDQLDELRKKFEEAQRGRAEDRLKIDDLLVTLSNLEAEINLLKRRIALLEEEVARLKKENFRLTSELQRVRIELDQETLLRIDNQNKVKTILEEIDFMKRGFETELKELQAQAARDTTSENREYFKNELANAMRDIRAEYDQIMNGNRNDMESWYQLRVQEINTQSNRQNAENNYQKEEVKRLRNQTSELRQKLSDLESRNLLLEKQIEDLNYQLEDDQRSYEAALNDKDAQIRKLREECQALMVELQMLLDTKQTLDGELKVYRQMLEGNSEGNGLRQLVEKVVRTSAINEEADTETMRVVKGEHSSRTSYQRSAKGNVAIKETSPEGKFVILENTHRAKEEPLGDWKLKRKIDGKREIVFTFPSDYILHPFQSVKIFARGQGIANPPEVLIFEGDETFGVGANVQTILYNNKGEERATHIQRQSQQTTSS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	TDPDSYRSSITSRPS CCHHHHHHCCCCCCC	20.19	19530675
10	Phosphorylation	DPDSYRSSITSRPSF CHHHHHHCCCCCCCC	22.38	19530675
12	Phosphorylation	DSYRSSITSRPSFNR HHHHHCCCCCCCCCC	22.19	18806794
13	Phosphorylation	SYRSSITSRPSFNRT HHHHCCCCCCCCCCE	40.29	18806794
16	Phosphorylation	SSITSRPSFNRTVTS HCCCCCCCCCCEECC	33.76	19060867
23	Phosphorylation	SFNRTVTSSSQNYGA CCCCEECCCCCCCCC	24.53	21082442
24	Phosphorylation	FNRTVTSSSQNYGAP CCCEECCCCCCCCCC	26.95	19530675
25	Phosphorylation	NRTVTSSSQNYGAPG CCEECCCCCCCCCCC	23.39	19060867
28	Phosphorylation	VTSSSQNYGAPGSGN ECCCCCCCCCCCCCC	13.66	27067626
33	Phosphorylation	QNYGAPGSGNRVLKI CCCCCCCCCCCEEEE	31.66	19060867
42	Phosphorylation	NRVLKIVTETHSSSV CCEEEEEEEECCCCC	38.34	18806794
44	Phosphorylation	VLKIVTETHSSSVSS EEEEEEEECCCCCCC	20.07	19530675
46	Phosphorylation	KIVTETHSSSVSSGL EEEEEECCCCCCCCC	31.56	19530675
47	Phosphorylation	IVTETHSSSVSSGLS EEEEECCCCCCCCCC	27.44	19530675
48	Phosphorylation	VTETHSSSVSSGLSP EEEECCCCCCCCCCC	29.09	19530675
50	Phosphorylation	ETHSSSVSSGLSPYG EECCCCCCCCCCCCC	22.19	18806794
51	Phosphorylation	THSSSVSSGLSPYGQ ECCCCCCCCCCCCCC	41.41	19060867
54	Phosphorylation	SSVSSGLSPYGQNAA CCCCCCCCCCCCCHH	21.43	28854356
56	Phosphorylation	VSSGLSPYGQNAAST CCCCCCCCCCCHHHH	28.15	27067626
436	Phosphorylation	LVEKVVRTSAINEEA HHHHHHHHHCCCCCC	15.76	28854356
437	Phosphorylation	VEKVVRTSAINEEAD HHHHHHHHCCCCCCC	19.31	28854356
575	Phosphorylation	ATHIQRQSQQTTSS- HHHHHHHHHHCCCC-	26.84	28854356
578	Phosphorylation	IQRQSQQTTSS---- HHHHHHHCCCC----	22.47	30078680
579	Phosphorylation	QRQSQQTTSS----- HHHHHHCCCC-----	23.72	30078680
580	Phosphorylation	RQSQQTTSS------ HHHHHCCCC------	37.12	30078680
581	Phosphorylation	QSQQTTSS------- HHHHCCCC-------	41.99	30078680

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IFA2_CAEEL !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IFA2_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IFA2_CAEEL !!

Protein-Protein Interaction

Oops, there are no PPI records of IFA2_CAEEL !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.