IFA1_CAEEL - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IFA1_CAEEL
• UniProt AC: P90901
• Protein Name: Intermediate filament protein ifa-1
• Gene Name: ifa-1
• Organism: Caenorhabditis elegans.
• Sequence Length: 575
• Subcellular Localization: Cytoplasm .
• Protein Description: Cytoplasmic intermediate filaments make up the structural component of the cytoskeleton providing mechanical strength to cells. Essential protein required during embryogenesis especially for survival past the L1 larva stage, involved in intestine morphogenesis..
• Protein Sequence: MMEITRETMSFTSTTPSARAPLGGRTTGNVTSQDRMLKIVTEMRSGAGSGLSPFGQNAASTIRDSREREKKEMSDLNDRLASYIEKVRFLEAQNRKLAADLDALRSKWGKDTHNIRNMYEGELVDAQKLIDETNKQRKDMEGQLKKMQDELAEMRRKLEDATKGREQDRAKIDALLVTLSNLEAEISLLKRRIAQLEDEVKRIKQENQRLLSELQRARTDLDQETLNRIDYQNQVQTLLEEIDFLRRVHDNEIKELQTLASRDTTPENREFFKNELSSAIRDIREEYDQVNNVHRNDMESWYRLKVQEIQTQSARQNMEQGYAKEEVKRLRTQLSDLRGKLADLESRNSLLEKQIQELNYQLEDDQRSYEAALNDRDSQIRKMREECQALMVELQMLLDTKQTLDAEIAIYRKMLEGEENRAGLKQLVEQVVKTHAITQETDTETMRVVKGETASRQSFQRSAKGNVSIHEASPDGKFIVLQNTHRAKDEAIGEWKLKRRIDGKRENVYTLPRDFVLRAGKTLKIFARNQGVASPPDQLVYDAEDSFGSGNNVQTILFNKEGEERATHIQRQSTA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	EITRETMSFTSTTPS CCCCCCCCCCCCCCC	32.56	19530675
12	Phosphorylation	TRETMSFTSTTPSAR CCCCCCCCCCCCCCC	20.18	19530675
13	Phosphorylation	RETMSFTSTTPSARA CCCCCCCCCCCCCCC	28.42	19530675
14	Phosphorylation	ETMSFTSTTPSARAP CCCCCCCCCCCCCCC	39.40	19530675
15	Phosphorylation	TMSFTSTTPSARAPL CCCCCCCCCCCCCCC	18.27	19530675
17	Phosphorylation	SFTSTTPSARAPLGG CCCCCCCCCCCCCCC	28.44	19530675
31	Phosphorylation	GRTTGNVTSQDRMLK CCCCCCCCCHHHHHH	25.35	30078680
32	Phosphorylation	RTTGNVTSQDRMLKI CCCCCCCCHHHHHHH	26.29	19060867
41	Phosphorylation	DRMLKIVTEMRSGAG HHHHHHHHHHCCCCC	27.77	28854356
45	Phosphorylation	KIVTEMRSGAGSGLS HHHHHHCCCCCCCCC	31.52	28854356
49	Phosphorylation	EMRSGAGSGLSPFGQ HHCCCCCCCCCCCCC	35.71	28854356
52	Phosphorylation	SGAGSGLSPFGQNAA CCCCCCCCCCCCCHH	23.00	28854356
219	Phosphorylation	SELQRARTDLDQETL HHHHHHCCCCCHHHH	39.67	19530675
265	Phosphorylation	TLASRDTTPENREFF HHHHCCCCHHHHHHH	32.66	22923814
458	Phosphorylation	GETASRQSFQRSAKG CCCCCHHHHHHHHCC	23.41	28854356
468	Phosphorylation	RSAKGNVSIHEASPD HHHCCCEEEEECCCC	23.40	30078680
473	Phosphorylation	NVSIHEASPDGKFIV CEEEEECCCCCCEEE	22.12	22923814
573	Phosphorylation	ATHIQRQSTA----- HHHHHHCCCC-----	28.61	28854356
574	Phosphorylation	THIQRQSTA------ HHHHHCCCC------	28.22	28854356

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IFA1_CAEEL !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IFA1_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IFA1_CAEEL !!

Protein-Protein Interaction

Oops, there are no PPI records of IFA1_CAEEL !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.