IF6_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IF6_SCHPO
• UniProt AC: O94476
• Protein Name: Eukaryotic translation initiation factor 6 {ECO:0000255|HAMAP-Rule:MF_03132}
• Gene Name: tif6
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 244
• Subcellular Localization: Cytoplasm . Nucleus, nucleolus . Shuttles between cytoplasm and nucleus/nucleolus.
• Protein Description: Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export..
• Protein Sequence: MALRAQFENSNEIGVFSNLTNSYALVALGGSENFYSVFEAELGDVVPVVHTTIGGTRIIGRLTCGNRKGLLVPSSTTDNELQHLRNSLPDPVKIQRVDERLSALGNIVACNDYVALVHPDIERETEEIIADVLDVEVFRQTVAGNVLTGSYCALSNQGALVHPRTSIQEQDELSSLLQVPLVAGTINRGSDVIGAGLVVNDWCAFAGLDTTATELAVCESIFKLQDAQPSAIISNRDTLVESYT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
174	Phosphorylation	IQEQDELSSLLQVPL HHHHHHHHHHHCCCC	19.52	29996109
175	Phosphorylation	QEQDELSSLLQVPLV HHHHHHHHHHCCCCC	45.80	29996109
230	Phosphorylation	KLQDAQPSAIISNRD HCCCCCCCEEECCCC	21.73	29996109

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
174	S	Phosphorylation	Kinase	CK1	-	Uniprot
175	S	Phosphorylation	Kinase	CK1	-	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IF6_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IF6_SCHPO !!

Protein-Protein Interaction

Oops, there are no PPI records of IF6_SCHPO !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.