| UniProt ID | IF4G_ARATH | |
|---|---|---|
| UniProt AC | Q76E23 | |
| Protein Name | Eukaryotic translation initiation factor 4G | |
| Gene Name | EIF4G | |
| Organism | Arabidopsis thaliana (Mouse-ear cress). | |
| Sequence Length | 1727 | |
| Subcellular Localization | ||
| Protein Description | Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. Plays a role in the accumulation of some potyvirus during viral infection. Required for the accumulation of cucumber mosaic virus 3a protein and turnip crinkle virus p28 replication protein during viral infection. These proteins are necessary for cell-to-cell movement of the virus.. | |
| Protein Sequence | MSYNQSRPDRSETQYRRTGRSTGNQQQQQQHRSSSAAGYGKGAGAPGSAPAPSTYPDNSSLSSNRSFKKPGNAQGGGQPRVNLPPVNHPNNHNNGPNAHSRSQVTGEPGVGGPTNPTESFNRNTGPIPKAPTSQSTVMSSKINETPNTAKVAASGDASQAFPLQFGSLGPDLMVPARTTSAPPNMDDQKRAQMQQSSLRTASNVPASVPKKDSSNKGADNQLMRKEGHNPSSEKADIQVPHIAPPSQTQKSPITNIRMPSVQTPYQHTQVPHPVHFGGPNMHMQTPVTATSFQMPMPMALSMGNTPQIPPQVFYQGHPPHPMHHQGMMHQAQGHGFATPMGAQIHPQLGHVGVGLSPQYPQQQGGKYGGARKTTPVKITHPDTHEELRLDRRGDPYSEGDSTALKPHSNPPPRSQPVSSFAPRPVNLVQPSYNSNTMIYPPVSVPLNNGPMSSAQAPRYHYPVIDGSQRVQLINQPAHTAPQLIRPAAPAHLSSDSTSSVKARNAQNVMSSALPVNAKVSVKPAGVSEKLGSPKDRSHGEVNISLSQKNVEACSLSSSQQPKPSFVSGVPNSSAPPAKSPVETVPLAKSSVETVPPVKSSVETAPVTTTEIRRAEMVSESISVEDQTCKVEPPHNLTENRGQTMPDSLVSDPETATVAAKENLSLPATNGFRKQLLKVSTTSDAPTSDSVDTSIDKSTEGSSHASSEISGSSPQEKDLKCDNRTASDKLDERSVISDAKHETLSGVLEKAQNEVDGATDVCPVSEKLAVTDDTSSDLPHSTHVLSSTVPLGHSETHKSAVETNTRRNTSTKGKKKIKEILQKADAAGTTSDLYMAYKGPEEKKESSNVVHDVSNQNLLPAIPQAVEAIVDTEPVKNEPEDWEDAADVSTPKLETADNSVNAKRGSSDEVSDNCINTEKKYSRDFLLKFADLCTALPEGFDVSPDIANALIVAYMGASHHEHDSYPTPGKVMDRQASGARLDRRPSNVAGDDRWTKNQGSLPAGYGGNVGFRPGQGGNSGVLRNPRMQGPIISRPMQPVGPMGGMGRNTPDLERWQRGSNFQQKGLFPSPHTPMQVMHKAERKYQVGTIADEEQAKQRQLKSILNKLTPQNFEKLFEQVKSVNIDNAVTLSGVISQIFDKALMEPTFCEMYADFCFHLSGALPDFNENGEKITFKRLLLNKCQEEFERGEKEEEEASRVAEEGQVEQTEEEREEKRLQVRRRMLGNIRLIGELYKKRMLTEKIMHACIQKLLGYNQDPHEENIEALCKLMSTIGVMIDHNKAKFQMDGYFEKMKMLSCKQELSSRVRFMLINAIDLRKNKWQERMKVEGPKKIEEVHRDAAQERQTQANRLSRGPSMNSSGRRGHMEFSSPRGGGGMLSPPAAQMGSYHGPPQGRGFSNQDIRFDDRPSYEPRMVPMPQRSVCEEPITLGPQGGLGQGMSIRRPAVASNTYQSDATQAGGGDSRRPAGGLNGFGSHRPASPVTHGRSSPQERGTAYVHREFASLSRASDLSPEVSSARQVLQGPSATVNSPRENALSEEQLENLSLSAIKEYYSARDENEIGMCMKDMNSPAYHPTMISLWVTDSFERKDKERDLLAKLLVNLVKSADNALNEVQLVKGFESVLKTLEDAVNDAPKAAEFLGRIFGKSVTEKVVTLTEIGRLIQEGGEEPGSLIEFGLGGDVLGSVLEMIKTEAGEETLVEIRRSSGLRIENFKPHAPNRSKILEKFT | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 34 | Phosphorylation | QQQQHRSSSAAGYGK HHHHHHHHCHHCCCC | 25561503 | ||
| 35 | Phosphorylation | QQQHRSSSAAGYGKG HHHHHHHCHHCCCCC | 25561503 | ||
| 66 | Phosphorylation | SSLSSNRSFKKPGNA CCCCCCCCCCCCCCC | 30291188 | ||
| 102 (in isoform 2) | Phosphorylation | - | 29654922 | ||
| 112 (in isoform 2) | Phosphorylation | - | 22631563 | ||
| 114 | Phosphorylation | EPGVGGPTNPTESFN CCCCCCCCCCCHHCC | 22631563 | ||
| 178 | Phosphorylation | DLMVPARTTSAPPNM CCEEECCCCCCCCCC | 19376835 | ||
| 179 | Phosphorylation | LMVPARTTSAPPNMD CEEECCCCCCCCCCC | 25561503 | ||
| 180 | Phosphorylation | MVPARTTSAPPNMDD EEECCCCCCCCCCCH | 27531888 | ||
| 200 | Phosphorylation | MQQSSLRTASNVPAS HHHHHHHHHHCCCCC | 22631563 | ||
| 202 | Phosphorylation | QSSLRTASNVPASVP HHHHHHHHCCCCCCC | 22631563 | ||
| 248 | Phosphorylation | HIAPPSQTQKSPITN CCCCCCCCCCCCCCC | 29654922 | ||
| 532 | Phosphorylation | GVSEKLGSPKDRSHG CHHHCCCCCCCCCCC | 27531888 | ||
| 579 | Phosphorylation | SSAPPAKSPVETVPL CCCCCCCCCCCCCCC | 25561503 | ||
| 650 | Phosphorylation | TMPDSLVSDPETATV CCCHHHCCCHHHHCH | 30589143 | ||
| 701 | Phosphorylation | IDKSTEGSSHASSEI CCCCCCCCCCCCCCC | 23776212 | ||
| 702 | Phosphorylation | DKSTEGSSHASSEIS CCCCCCCCCCCCCCC | 23776212 | ||
| 705 | Phosphorylation | TEGSSHASSEISGSS CCCCCCCCCCCCCCC | 23776212 | ||
| 706 | Phosphorylation | EGSSHASSEISGSSP CCCCCCCCCCCCCCC | 23776212 | ||
| 709 | Phosphorylation | SHASSEISGSSPQEK CCCCCCCCCCCCCCC | 23776212 | ||
| 711 | Phosphorylation | ASSEISGSSPQEKDL CCCCCCCCCCCCCCC | 23776212 | ||
| 712 | Phosphorylation | SSEISGSSPQEKDLK CCCCCCCCCCCCCCC | 23776212 | ||
| 724 | Phosphorylation | DLKCDNRTASDKLDE CCCCCCCCHHHHCCC | 25561503 | ||
| 726 | Phosphorylation | KCDNRTASDKLDERS CCCCCCHHHHCCCCH | 25561503 | ||
| 802 | Phosphorylation | THKSAVETNTRRNTS HHHHHHHCCCCCCCC | 29797451 | ||
| 888 | Phosphorylation | WEDAADVSTPKLETA HHHHCCCCCCCCCCC | 27288362 | ||
| 889 | Phosphorylation | EDAADVSTPKLETAD HHHCCCCCCCCCCCC | 27288362 | ||
| 898 | Phosphorylation | KLETADNSVNAKRGS CCCCCCCCCCCCCCC | 27288362 | ||
| 905 | Phosphorylation | SVNAKRGSSDEVSDN CCCCCCCCCCHHHHH | 23776212 | ||
| 906 | Phosphorylation | VNAKRGSSDEVSDNC CCCCCCCCCHHHHHH | 23776212 | ||
| 910 | Phosphorylation | RGSSDEVSDNCINTE CCCCCHHHHHHCCCC | 23776212 | ||
| 916 | Phosphorylation | VSDNCINTEKKYSRD HHHHHCCCCCHHCHH | 23776212 | ||
| 985 | Phosphorylation | ARLDRRPSNVAGDDR CCCCCCCCCCCCCCC | 19376835 | ||
| 1018 | Phosphorylation | RPGQGGNSGVLRNPR CCCCCCCCCCCCCCC | 27288362 | ||
| 1068 | Phosphorylation | QQKGLFPSPHTPMQV CCCCCCCCCCCCHHH | 19880383 | ||
| 1355 | Phosphorylation | NRLSRGPSMNSSGRR HHHHCCCCCCCCCCC | 23111157 | ||
| 1358 | Phosphorylation | SRGPSMNSSGRRGHM HCCCCCCCCCCCCCC | 25561503 | ||
| 1368 | Phosphorylation | RRGHMEFSSPRGGGG CCCCCCCCCCCCCCC | 27288362 | ||
| 1369 | Phosphorylation | RGHMEFSSPRGGGGM CCCCCCCCCCCCCCC | 19880383 | ||
| 1378 | Phosphorylation | RGGGGMLSPPAAQMG CCCCCCCCCCHHHCC | 25561503 | ||
| 1474 | Phosphorylation | GGLNGFGSHRPASPV CCCCCCCCCCCCCCC | 29654922 | ||
| 1479 | Phosphorylation | FGSHRPASPVTHGRS CCCCCCCCCCCCCCC | 29654922 | ||
| 1482 | Phosphorylation | HRPASPVTHGRSSPQ CCCCCCCCCCCCCCC | 25561503 | ||
| 1502 | Phosphorylation | YVHREFASLSRASDL HHHHHHHHHHCCCCC | 29654922 | ||
| 1507 | Phosphorylation | FASLSRASDLSPEVS HHHHHCCCCCCHHHH | 23776212 | ||
| 1510 | Phosphorylation | LSRASDLSPEVSSAR HHCCCCCCHHHHHHH | 23776212 | ||
| 1514 | Phosphorylation | SDLSPEVSSARQVLQ CCCCHHHHHHHHHHC | 23776212 | ||
| 1515 | Phosphorylation | DLSPEVSSARQVLQG CCCHHHHHHHHHHCC | 23776212 | ||
| 1524 | Phosphorylation | RQVLQGPSATVNSPR HHHHCCCCCCCCCHH | 23776212 | ||
| 1526 | Phosphorylation | VLQGPSATVNSPREN HHCCCCCCCCCHHHC | 23776212 | ||
| 1529 | Phosphorylation | GPSATVNSPRENALS CCCCCCCCHHHCCCC | 30291188 | ||
| 1605 | Phosphorylation | LLVNLVKSADNALNE HHHHHHHHHHHHHHH | 24894044 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of IF4G_ARATH !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of IF4G_ARATH !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of IF4G_ARATH !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of IF4G_ARATH !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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