IF4A2_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IF4A2_RAT
• UniProt AC: Q5RKI1
• Protein Name: Eukaryotic initiation factor 4A-II
• Gene Name: Eif4a2
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 407
• Protein Description: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity)..
• Protein Sequence: MSGGSADYNREHGGPEGMDPDGVIESNWNEIVDNFDDMNLKESLLRGIYAYGFEKPSAIQQRAIIPCIKGYDVIAQAQSGTGKTATFAISILQQLEIEFKETQALVLAPTRELAQQIQKVILALGDYMGATCHACIGGTNVRNEMQKLQAEAPHIVVGTPGRVFDMLNRRYLSPKWIKMFVLDEADEMLSRGFKDQIYEIFQKLNTSIQVVLLSATMPTDVLEVTKKFMRDPIRILVKKEELTLEGIKQFYINVEREEWKLDTLCDLYETLTITQAVIFLNTRRKVDWLTEKMHARDFTVSALHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINFVTEEDKRILRDIETFYNTTVEEMPMNVADLI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
49	Phosphorylation	ESLLRGIYAYGFEKP HHHHHHHHHCCCCCC	9.15	-
55	Acetylation	IYAYGFEKPSAIQQR HHHCCCCCCCHHHHH	41.85	37986853
55	Ubiquitination	IYAYGFEKPSAIQQR HHHCCCCCCCHHHHH	41.85	-
79	Phosphorylation	DVIAQAQSGTGKTAT EEEEEECCCCCHHHH	41.14	22817900
81	Phosphorylation	IAQAQSGTGKTATFA EEEECCCCCHHHHHH	40.53	22817900
84	Phosphorylation	AQSGTGKTATFAISI ECCCCCHHHHHHHHH	32.07	22817900
159	Phosphorylation	APHIVVGTPGRVFDM CCEEEECCCHHHHHH	15.80	-
175	Acetylation	NRRYLSPKWIKMFVL CCCCCCHHHHHEEEC	59.17	22902405
194	Acetylation	EMLSRGFKDQIYEIF HHHHCCCHHHHHHHH	52.10	22902405
227	Acetylation	DVLEVTKKFMRDPIR CHHHHHHHHHCCCEE	34.72	22902405
239	Acetylation	PIRILVKKEELTLEG CEEEEEECCEECHHH	49.28	22902405
243	Phosphorylation	LVKKEELTLEGIKQF EEECCEECHHHHHHE	26.50	23984901
290	Phosphorylation	RRKVDWLTEKMHARD CCCCHHHHHHHHHCC	29.34	23984901
292	Acetylation	KVDWLTEKMHARDFT CCHHHHHHHHHCCCC	30.65	22902405
310	Acetylation	LHGDMDQKERDVIMR HCCCCCHHHHHHHHH	50.91	22902405
321	Phosphorylation	VIMREFRSGSSRVLI HHHHHHHCCCCCEEE	48.63	23984901
323	Phosphorylation	MREFRSGSSRVLITT HHHHHCCCCCEEEEH	19.06	23984901
324	Phosphorylation	REFRSGSSRVLITTD HHHHCCCCCEEEEHH	29.90	23984901
329	Phosphorylation	GSSRVLITTDLLARG CCCCEEEEHHHHHCC	15.31	23984901
382	Ubiquitination	NFVTEEDKRILRDIE EEECHHHHHHHHHHH	44.62	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IF4A2_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IF4A2_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IF4A2_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of IF4A2_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.