IF4A2_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IF4A2_ARATH
• UniProt AC: P41377
• Protein Name: Eukaryotic initiation factor 4A-2
• Gene Name: TIF4A-2
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 412
• Subcellular Localization: Cytoplasm.
• Protein Description: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity)..
• Protein Sequence: MAGSAPEGTQFDTRQFDQRLNEVLDGQDEFFTSYDEVHESFDAMGLQENLLRGIYAYGFEKPSAIQQRGIVPFCKGLDVIQQAQSGTGKTATFCSGVLQQLDYALLQCQALVLAPTRELAQQIEKVMRALGDYQGVKVHACVGGTSVREDQRILQAGVHVVVGTPGRVFDMLRRQSLRPDCIKMFVLDEADEMLSRGFKDQIYDIFQLLPPKIQVGVFSATMPPEALEITRKFMSKPVRILVKRDELTLEGIKQFYVNVEKEDWKLETLCDLYETLAITQSVIFVNTRRKVDWLTDKMRSRDHTVSATHGDMDQNTRDIIMREFRSGSSRVLITTDLLARGIDVQQVSLVINFDLPTQPENYLHRIGRSGRFGRKGVAINFVTLDDQRMLFDIQKFYNVVVEELPSNVADLL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAGSAPEGT ------CCCCCCCCC	22.20	22223895
4	Phosphorylation	----MAGSAPEGTQF ----CCCCCCCCCCC	30.98	19880383
9	Phosphorylation	AGSAPEGTQFDTRQF CCCCCCCCCCCHHHH	25.13	19880383
85	Phosphorylation	DVIQQAQSGTGKTAT HHHHHHHCCCCHHHH	41.14	19880383
87	Phosphorylation	IQQAQSGTGKTATFC HHHHHCCCCHHHHHH	40.53	23111157
145	Phosphorylation	VHACVGGTSVREDQR EEEEECCCCHHHHHH	20.37	30291188
146	Phosphorylation	HACVGGTSVREDQRI EEEECCCCHHHHHHH	23.58	27532006
312	Sulfoxidation	VSATHGDMDQNTRDI CCCCCCCCCCCHHHH	7.27	23289948
334	Phosphorylation	GSSRVLITTDLLARG CCCEEEEEHHHHHCC	15.31	19880383

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IF4A2_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IF4A2_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IF4A2_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of IF4A2_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.