UniProt ID | IF2B_SCHPO | |
---|---|---|
UniProt AC | P56329 | |
Protein Name | Probable eukaryotic translation initiation factor 2 subunit beta | |
Gene Name | tif212 | |
Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). | |
Sequence Length | 321 | |
Subcellular Localization | ||
Protein Description | eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (By similarity).. | |
Protein Sequence | MTETEAVVDQIDLNGALPEKKKKPKKSVAFDDEVDAVSKDGPEASSAGATDEDDSERKSSAKDLTTPVTEGEVDELKDMFSSMKKKKKSKKSSASAEEQTEDITTESGELDFSSMKKKKKKKKSADLSAFEKELEASSTGDATSDLSKQTFDSENMGEHAWLKSDRDYYYPELLNRFFTLLRTNNPELAGEKRKYTIVPPSVHREGKKTIFANISDISKRMHRSLDHVIQFLFAELGTSGSVDGSSRLIIKGRFQQKQIENVLRRYIVEYVTCKTCKSPDTILTKENRIFFMTCEACGSVRSVQAIKTGYQAQIGKRKHVS | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
2 | Phosphorylation | ------MTETEAVVD ------CCCCHHHHC | 52.17 | 29996109 | |
27 | Phosphorylation | KKKKPKKSVAFDDEV CCCCCCCCCCCCCCC | 25.46 | 25720772 | |
38 | Phosphorylation | DDEVDAVSKDGPEAS CCCCCHHHCCCCCHH | 27.10 | 24763107 | |
45 | Phosphorylation | SKDGPEASSAGATDE HCCCCCHHHCCCCCC | 21.04 | 28889911 | |
46 | Phosphorylation | KDGPEASSAGATDED CCCCCHHHCCCCCCC | 37.46 | 28889911 | |
50 | Phosphorylation | EASSAGATDEDDSER CHHHCCCCCCCCCCC | 38.72 | 28889911 | |
55 | Phosphorylation | GATDEDDSERKSSAK CCCCCCCCCCHHHCC | 52.18 | 25720772 | |
60 | Phosphorylation | DDSERKSSAKDLTTP CCCCCHHHCCCCCCC | 42.23 | 25720772 | |
66 | Phosphorylation | SSAKDLTTPVTEGEV HHCCCCCCCCCCHHH | 24.06 | 24763107 | |
124 | Phosphorylation | KKKKKKKSADLSAFE CCCCCCCCCCHHHHH | 35.58 | 28889911 | |
128 | Phosphorylation | KKKSADLSAFEKELE CCCCCCHHHHHHHHH | 31.31 | 28889911 | |
137 | Phosphorylation | FEKELEASSTGDATS HHHHHHHCCCCCCCC | 21.03 | 28889911 | |
138 | Phosphorylation | EKELEASSTGDATSD HHHHHHCCCCCCCCH | 43.38 | 28889911 | |
139 | Phosphorylation | KELEASSTGDATSDL HHHHHCCCCCCCCHH | 36.26 | 28889911 | |
143 | Phosphorylation | ASSTGDATSDLSKQT HCCCCCCCCHHHHHC | 27.75 | 27738172 | |
144 | Phosphorylation | SSTGDATSDLSKQTF CCCCCCCCHHHHHCC | 37.97 | 27738172 | |
164 | Phosphorylation | GEHAWLKSDRDYYYP CCCEEECCCCCCCHH | 35.39 | 25720772 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of IF2B_SCHPO !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of IF2B_SCHPO !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of IF2B_SCHPO !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
Oops, there are no PPI records of IF2B_SCHPO !! |
Kegg Drug | ||||||
---|---|---|---|---|---|---|
DrugBank | ||||||
There are no disease associations of PTM sites. |
loading...