IDHC_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IDHC_MOUSE
• UniProt AC: O88844
• Protein Name: Isocitrate dehydrogenase [NADP] cytoplasmic
• Gene Name: Idh1
• Organism: Mus musculus (Mouse).
• Sequence Length: 414
• Subcellular Localization: Cytoplasm.
• Protein Sequence: MSRKIQGGSVVEMQGDEMTRIIWELIKEKLILPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPKDGTQKVTYMVHDFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKKYKSQFEAQKICYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWSRGLAHRAKLDNNTELSFFAKALEDVCIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKAKLAQAKL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSRKIQGGS ------CCCCCCCCC	42.13	30635358
2	Acetylation	------MSRKIQGGS ------CCCCCCCCC	42.13	-
4	Ubiquitination	----MSRKIQGGSVV ----CCCCCCCCCEE	31.88	-
4	Malonylation	----MSRKIQGGSVV ----CCCCCCCCCEE	31.88	26320211
9	Phosphorylation	SRKIQGGSVVEMQGD CCCCCCCCEEEECCC	29.79	30635358
19	Phosphorylation	EMQGDEMTRIIWELI EECCCHHHHHHHHHH	19.37	30635358
27	Succinylation	RIIWELIKEKLILPY HHHHHHHHHCCCCCE	62.51	23954790
27	Ubiquitination	RIIWELIKEKLILPY HHHHHHHHHCCCCCE	62.51	-
27	Acetylation	RIIWELIKEKLILPY HHHHHHHHHCCCCCE	62.51	22826441
42	Phosphorylation	VELDLHSYDLGIENR EEEEEEECCCCCCCC	12.39	-
58	Succinylation	ATNDQVTKDAAEAIK CCCCCCCHHHHHHHH	46.65	23954790
58	Acetylation	ATNDQVTKDAAEAIK CCCCCCCHHHHHHHH	46.65	23864654
58	Ubiquitination	ATNDQVTKDAAEAIK CCCCCCCHHHHHHHH	46.65	27667366
58	Malonylation	ATNDQVTKDAAEAIK CCCCCCCHHHHHHHH	46.65	26320211
66	Malonylation	DAAEAIKKYNVGVKC HHHHHHHHCCCCCEE	35.62	26320211
73	S-nitrosocysteine	KYNVGVKCATITPDE HCCCCCEEEEECCCH	3.62	-
73	S-nitrosylation	KYNVGVKCATITPDE HCCCCCEEEEECCCH	3.62	21278135
73	S-palmitoylation	KYNVGVKCATITPDE HCCCCCEEEEECCCH	3.62	26165157
77	Phosphorylation	GVKCATITPDEKRVE CCEEEEECCCHHHHH	21.97	-
81	Malonylation	ATITPDEKRVEEFKL EEECCCHHHHHHHHH	69.95	26320211
81	Acetylation	ATITPDEKRVEEFKL EEECCCHHHHHHHHH	69.95	23576753
81	Ubiquitination	ATITPDEKRVEEFKL EEECCCHHHHHHHHH	69.95	-
87	Ubiquitination	EKRVEEFKLKQMWKS HHHHHHHHHHHHHCC	59.04	27667366
87	Acetylation	EKRVEEFKLKQMWKS HHHHHHHHHHHHHCC	59.04	23864654
93	Succinylation	FKLKQMWKSPNGTIR HHHHHHHCCCCCCCC	51.17	23806337
93	Malonylation	FKLKQMWKSPNGTIR HHHHHHHCCCCCCCC	51.17	26320211
93	Ubiquitination	FKLKQMWKSPNGTIR HHHHHHHCCCCCCCC	51.17	27667366
93	Acetylation	FKLKQMWKSPNGTIR HHHHHHHCCCCCCCC	51.17	23864654
94	Phosphorylation	KLKQMWKSPNGTIRN HHHHHHCCCCCCCCH	14.21	23737553
115	Succinylation	FREAIICKNIPRLVT HHEHHHHCCCHHHCC	47.72	24315375
115	Malonylation	FREAIICKNIPRLVT HHEHHHHCCCHHHCC	47.72	26320211
115	Acetylation	FREAIICKNIPRLVT HHEHHHHCCCHHHCC	47.72	23576753
126	Succinylation	RLVTGWVKPIIIGRH HHCCCCCCCEEEEEC	24.80	-
126	Ubiquitination	RLVTGWVKPIIIGRH HHCCCCCCCEEEEEC	24.80	-
126	Acetylation	RLVTGWVKPIIIGRH HHCCCCCCCEEEEEC	24.80	22826441
126	Succinylation	RLVTGWVKPIIIGRH HHCCCCCCCEEEEEC	24.80	23806337
135	Phosphorylation	IIIGRHAYGDQYRAT EEEEECCCCCCCEEE	18.34	25367039
151	Succinylation	FVVPGPGKVEITYTP EEECCCCEEEEEEEC	39.57	23954790
151	Acetylation	FVVPGPGKVEITYTP EEECCCCEEEEEEEC	39.57	22733758
151	Malonylation	FVVPGPGKVEITYTP EEECCCCEEEEEEEC	39.57	26320211
151	Ubiquitination	FVVPGPGKVEITYTP EEECCCCEEEEEEEC	39.57	27667366
159	Succinylation	VEITYTPKDGTQKVT EEEEEECCCCCEEEE	62.07	23954790
159	Malonylation	VEITYTPKDGTQKVT EEEEEECCCCCEEEE	62.07	26320211
159	Sumoylation	VEITYTPKDGTQKVT EEEEEECCCCCEEEE	62.07	28289178
159	Acetylation	VEITYTPKDGTQKVT EEEEEECCCCCEEEE	62.07	23201123
159	Ubiquitination	VEITYTPKDGTQKVT EEEEEECCCCCEEEE	62.07	27667366
167	Phosphorylation	DGTQKVTYMVHDFEE CCCEEEEEEEEEECC	10.50	22802335
208	Phosphorylation	LSKGWPLYLSTKNTI HHCCCCEEEEECCCH	8.43	25195567
210	Phosphorylation	KGWPLYLSTKNTILK CCCCEEEEECCCHHH	24.63	26643407
211	Phosphorylation	GWPLYLSTKNTILKK CCCEEEEECCCHHHH	26.22	26643407
212	Succinylation	WPLYLSTKNTILKKY CCEEEEECCCHHHHC	49.03	26388266
212	Ubiquitination	WPLYLSTKNTILKKY CCEEEEECCCHHHHC	49.03	-
224	Phosphoglycerylation	KKYDGRFKDIFQEIY HHCCCCHHHHHHHHH	48.86	-
224	Acetylation	KKYDGRFKDIFQEIY HHCCCCHHHHHHHHH	48.86	23576753
224	Ubiquitination	KKYDGRFKDIFQEIY HHCCCCHHHHHHHHH	48.86	-
224	Malonylation	KKYDGRFKDIFQEIY HHCCCCHHHHHHHHH	48.86	26320211
233	Succinylation	IFQEIYDKKYKSQFE HHHHHHCHHCHHHHH	40.82	23954790
233	Acetylation	IFQEIYDKKYKSQFE HHHHHHCHHCHHHHH	40.82	23576753
233	Malonylation	IFQEIYDKKYKSQFE HHHHHHCHHCHHHHH	40.82	26320211
233	Ubiquitination	IFQEIYDKKYKSQFE HHHHHHCHHCHHHHH	40.82	27667366
234	Acetylation	FQEIYDKKYKSQFEA HHHHHCHHCHHHHHH	55.82	7622383
235	Phosphorylation	QEIYDKKYKSQFEAQ HHHHCHHCHHHHHHH	22.93	29472430
236	Malonylation	EIYDKKYKSQFEAQK HHHCHHCHHHHHHHH	46.81	26320211
236	Ubiquitination	EIYDKKYKSQFEAQK HHHCHHCHHHHHHHH	46.81	27667366
237	Phosphorylation	IYDKKYKSQFEAQKI HHCHHCHHHHHHHHH	36.69	23684622
243	Acetylation	KSQFEAQKICYEHRL HHHHHHHHHHHHHHC	41.62	23576753
243	Malonylation	KSQFEAQKICYEHRL HHHHHHHHHHHHHHC	41.62	26320211
243	Ubiquitination	KSQFEAQKICYEHRL HHHHHHHHHHHHHHC	41.62	-
245	S-palmitoylation	QFEAQKICYEHRLID HHHHHHHHHHHHCHH	4.14	26165157
269	S-nitrosocysteine	EGGFIWACKNYDGDV CCCEEEEEECCCCCC	1.44	-
269	Glutathionylation	EGGFIWACKNYDGDV CCCEEEEEECCCCCC	1.44	19291592
269	S-palmitoylation	EGGFIWACKNYDGDV CCCEEEEEECCCCCC	1.44	28526873
269	S-nitrosylation	EGGFIWACKNYDGDV CCCEEEEEECCCCCC	1.44	24926564
311	Phosphorylation	EAEAAHGTVTRHYRM EEHHHCCCCHHHHCC	14.61	28059163
321	Acetylation	RHYRMYQKGQETSTN HHHCCHHCCCCCCCC	45.11	-
321	Malonylation	RHYRMYQKGQETSTN HHHCCHHCCCCCCCC	45.11	26320211
321	Ubiquitination	RHYRMYQKGQETSTN HHHCCHHCCCCCCCC	45.11	27667366
337	Phosphorylation	IASIFAWSRGLAHRA HHHHHHHHHHCHHHH	17.03	26643407
345	Acetylation	RGLAHRAKLDNNTEL HHCHHHHCCCCCCCH	57.22	23236377
345	Ubiquitination	RGLAHRAKLDNNTEL HHCHHHHCCCCCCCH	57.22	27667366
345	Malonylation	RGLAHRAKLDNNTEL HHCHHHHCCCCCCCH	57.22	26320211
363	S-nitrosylation	AKALEDVCIETIEAG HHHHHHHHHHHHHHC	3.44	21278135
363	S-palmitoylation	AKALEDVCIETIEAG HHHHHHHHHHHHHHC	3.44	28526873
363	S-nitrosocysteine	AKALEDVCIETIEAG HHHHHHHHHHHHHHC	3.44	-
363	Glutathionylation	AKALEDVCIETIEAG HHHHHHHHHHHHHHC	3.44	24333276
379	Glutathionylation	MTKDLAACIKGLPNV CCHHHHHHHCCCCCC	2.48	24333276
381	Ubiquitination	KDLAACIKGLPNVQR HHHHHHHCCCCCCCH	55.04	-
389	Phosphorylation	GLPNVQRSDYLNTFE CCCCCCHHHCCCHHH	17.32	27180971
391	Phosphorylation	PNVQRSDYLNTFEFM CCCCHHHCCCHHHHH	11.78	25521595
394	Phosphorylation	QRSDYLNTFEFMDKL CHHHCCCHHHHHHHH	23.19	23984901
400	Ubiquitination	NTFEFMDKLGENLKA CHHHHHHHHCHHHHH	46.75	-
400	Succinylation	NTFEFMDKLGENLKA CHHHHHHHHCHHHHH	46.75	23806337
400	Acetylation	NTFEFMDKLGENLKA CHHHHHHHHCHHHHH	46.75	23806337
400	Succinylation	NTFEFMDKLGENLKA CHHHHHHHHCHHHHH	46.75	-
406	Malonylation	DKLGENLKAKLAQAK HHHCHHHHHHHHHHC	55.87	26320211

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IDHC_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
374	K	Acetylation	Acetylation at Lys-374 dramatically reduces catalytic activity.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IDHC_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of IDHC_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.