IDH3A_MOUSE - dbPTM
IDH3A_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID IDH3A_MOUSE
UniProt AC Q9D6R2
Protein Name Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
Gene Name Idh3a
Organism Mus musculus (Mouse).
Sequence Length 366
Subcellular Localization Mitochondrion.
Protein Description Catalytic subunit of the enzyme which catalyzes the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers..
Protein Sequence MAGSAWVSKVSRLLGAFHNTKQVTRGFAGGVQTVTLIPGDGIGPEISASVMKIFDAAKAPIQWEERNVTAIQGPGGKWMIPPEAKESMDKNKMGLKGPLKTPIAAGHPSMNLLLRKTFDLYANVRPCVSIEGYKTPYTDVNIVTIRENTEGEYSGIEHVIVDGVVQSIKLITEEASKRIAEFAFEYARNNHRSNVTAVHKANIMRMSDGLFLQKCREVAENCKDIKFNEMYLDTVCLNMVQDPSQFDVLVMPNLYGDILSDLCAGLIGGLGVTPSGNIGANGVAIFESVHGTAPDIAGKDMANPTALLLSAVMMLRHMGLFDHAAKIEAACFATIKDGKSLTKDLGGNAKCSDFTEEICRRVKDLD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Phosphorylation----MAGSAWVSKVS
----CCCHHHHHHHH		14.9320495213
58AcetylationMKIFDAAKAPIQWEE
HHHHHHHCCCCCEEC		57.3123864654
58UbiquitinationMKIFDAAKAPIQWEE
HHHHHHHCCCCCEEC		57.31-
58SuccinylationMKIFDAAKAPIQWEE
HHHHHHHCCCCCEEC		57.3123806337
77AcetylationAIQGPGGKWMIPPEA
EEECCCCCEECCHHH		39.2323864654
77SuccinylationAIQGPGGKWMIPPEA
EEECCCCCEECCHHH		39.23-
77SuccinylationAIQGPGGKWMIPPEA
EEECCCCCEECCHHH		39.2323806337
85AcetylationWMIPPEAKESMDKNK
EECCHHHHHCCCCCC		48.9723864654
90AcetylationEAKESMDKNKMGLKG
HHHHCCCCCCCCCCC		50.2323201123
96AcetylationDKNKMGLKGPLKTPI
CCCCCCCCCCCCCCC		53.402395061
100AcetylationMGLKGPLKTPIAAGH
CCCCCCCCCCCCCCC		56.2224062335
100UbiquitinationMGLKGPLKTPIAAGH
CCCCCCCCCCCCCCC		56.22-
100SuccinylationMGLKGPLKTPIAAGH
CCCCCCCCCCCCCCC		56.22-
100MalonylationMGLKGPLKTPIAAGH
CCCCCCCCCCCCCCC		56.2226320211
100GlutarylationMGLKGPLKTPIAAGH
CCCCCCCCCCCCCCC		56.2224703693
101PhosphorylationGLKGPLKTPIAAGHP
CCCCCCCCCCCCCCC		27.8419060867
127S-nitrosocysteineLYANVRPCVSIEGYK
HHCCCCCCEEECCCC		2.35-
127S-nitrosylationLYANVRPCVSIEGYK
HHCCCCCCEEECCCC		2.3521278135
167PhosphorylationIVDGVVQSIKLITEE
EECHHHHHHHHHCHH		15.3023140645
177SuccinylationLITEEASKRIAEFAF
HHCHHHHHHHHHHHH		55.6726388266
177UbiquitinationLITEEASKRIAEFAF
HHCHHHHHHHHHHHH		55.6727667366
177AcetylationLITEEASKRIAEFAF
HHCHHHHHHHHHHHH		55.6721728379
193PhosphorylationYARNNHRSNVTAVHK
HHHHCCCCCCHHHHH		28.2723684622
200SuccinylationSNVTAVHKANIMRMS
CCCHHHHHHHHHHHC		36.2123806337
200UbiquitinationSNVTAVHKANIMRMS
CCCHHHHHHHHHHHC		36.21-
200AcetylationSNVTAVHKANIMRMS
CCCHHHHHHHHHHHC		36.2123806337
214AcetylationSDGLFLQKCREVAEN
CCCCHHHHHHHHHHH		37.0924062335
216MethylationGLFLQKCREVAENCK
CCHHHHHHHHHHHCC		48.7558856157
216DimethylationGLFLQKCREVAENCK
CCHHHHHHHHHHHCC		48.75-
222GlutathionylationCREVAENCKDIKFNE
HHHHHHHCCCCCCCH		2.9324333276
222S-nitrosylationCREVAENCKDIKFNE
HHHHHHHCCCCCCCH		2.9321278135
222S-nitrosocysteineCREVAENCKDIKFNE
HHHHHHHCCCCCCCH		2.93-
223SuccinylationREVAENCKDIKFNEM
HHHHHHCCCCCCCHH		74.2526388266
223AcetylationREVAENCKDIKFNEM
HHHHHHCCCCCCCHH		74.2523576753
326AcetylationGLFDHAAKIEAACFA
CCHHHHHHHHHHEEE		41.6924062335
331S-nitrosylationAAKIEAACFATIKDG
HHHHHHHEEEEECCC		2.8424895380
331S-nitrosocysteineAAKIEAACFATIKDG
HHHHHHHEEEEECCC		2.84-
336SuccinylationAACFATIKDGKSLTK
HHEEEEECCCCCCCC		56.9523806337
336AcetylationAACFATIKDGKSLTK
HHEEEEECCCCCCCC		56.9523864654
339AcetylationFATIKDGKSLTKDLG
EEEECCCCCCCCCCC		53.0423201123
343SuccinylationKDGKSLTKDLGGNAK
CCCCCCCCCCCCCCC		57.1423806337
343UbiquitinationKDGKSLTKDLGGNAK
CCCCCCCCCCCCCCC		57.1427667366
343SuccinylationKDGKSLTKDLGGNAK
CCCCCCCCCCCCCCC		57.14-
343AcetylationKDGKSLTKDLGGNAK
CCCCCCCCCCCCCCC		57.1424062335
350SuccinylationKDLGGNAKCSDFTEE
CCCCCCCCCCHHHHH		37.97-
350SuccinylationKDLGGNAKCSDFTEE
CCCCCCCCCCHHHHH		37.9723806337
350AcetylationKDLGGNAKCSDFTEE
CCCCCCCCCCHHHHH		37.9723806337
351S-nitrosylationDLGGNAKCSDFTEEI
CCCCCCCCCHHHHHH		4.3624895380
359S-nitrosylationSDFTEEICRRVKDLD
CHHHHHHHHHHHCCC		2.2924895380
363AcetylationEEICRRVKDLD----
HHHHHHHHCCC----		51.252416169
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of IDH3A_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of IDH3A_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of IDH3A_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of IDH3A_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of IDH3A_MOUSE

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Related Literatures of Post-Translational Modification

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