IDE_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IDE_RAT
• UniProt AC: P35559
• Protein Name: Insulin-degrading enzyme
• Gene Name: Ide
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 1019
• Subcellular Localization: Cytoplasm. Cell membrane. Secreted.
• Protein Description: Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP..
• Protein Sequence: MRNGLVWLLHPALPSTLHSILGARPPPVKRLCGFPKQIYSTMNNPAIQRIEDHIVKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIPGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDASCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVREELLKFHSTYYSSNLMAICVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQQYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGKLHYYPLNGVLTAEYLLEEFRPDLIDMVLDKLRPENVRVAIVSKSFEGKTDRTEQWYGTQYKQEAIPEDVIQKWQNADLNGKFKLPTKNEFIPTNFEILALEKDATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKITEKMATFEIDKKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGVMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQRRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKAIEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNYDRDNIEVAYLKTLSKDDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPSQNDINLSEAPPLPQPEVIHNMTEFKRGLPLFPLVKPHINFMAAKL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
188	Phosphorylation	REVNAVDSEHEKNVM CCCCCCCCHHHHHHH	33.96	28432305
192	Acetylation	AVDSEHEKNVMNDAW CCCCHHHHHHHHHHH	57.67	22902405
192	Succinylation	AVDSEHEKNVMNDAW CCCCHHHHHHHHHHH	57.67	-
192	Succinylation	AVDSEHEKNVMNDAW CCCCHHHHHHHHHHH	57.67	-
303	Acetylation	EHLKQLYKIVPIKDI HHHHHHHHEEEHHHH	45.91	22902405
308	Acetylation	LYKIVPIKDIRNLYV HHHEEEHHHHEEEEE	40.82	22902405
308	Ubiquitination	LYKIVPIKDIRNLYV HHHEEEHHHHEEEEE	40.82	-
364	Acetylation	NTLVGGQKEGARGFM EEECCCCCCCCCEEE	62.48	22902405
436	Acetylation	RPRGYTSKIAGKLHY CCCCCCCCCCCEEEC	28.86	22902405
566	Acetylation	LWFKQDDKFFLPKAC CCCCCCCCCCCCHHH	46.43	22902405
651	Phosphorylation	KITEKMATFEIDKKR HHHHHHCCEEECHHH	20.50	22673903
656	Acetylation	MATFEIDKKRFEIIK HCCEEECHHHHHHHH	52.05	22902405
697	Succinylation	MTEVAWTKDELKEAL HHHHCCCHHHHHHHH	38.20	-
697	Succinylation	MTEVAWTKDELKEAL HHHHCCCHHHHHHHH	38.20	-
713	Acetylation	DVTLPRLKAFIPQLL CCCHHHHHHHHHHHH	42.40	22902405
901	Phosphorylation	LDKPKKLSAECAKYW CCCCCCCCHHHHHHH	30.79	23991683

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IDE_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IDE_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IDE_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of IDE_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.