dbPTM

ICR2_ARATH - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ICR2_ARATH
UniProt AC	Q9ZQC5
Protein Name	Interactor of constitutive active ROPs 2, chloroplastic
Gene Name	ICR2
Organism	Arabidopsis thaliana (Mouse-ear cress).
Sequence Length	583
Subcellular Localization	Plastid, chloroplast .
Protein Description	Acts as a scaffold, mediating interaction of ROPs with different proteins..
Protein Sequence	MQTPKPRPGSLEVPQKKSPASTPKTARKLKTSESDPVSSPNTKIRTPKTQSPKVVADRRSPRTPVNEIQKKRTGKTPELASQISQLQEELKKAKEQLSASEALKKEAQDQAEETKQQLMEINASEDSRIDELRKLSQERDKAWQSELEAMQRQHAMDSAALSSTMNEVQKLKAQLSESENVENLRMELNETLSLVEKLRGELFDAKEGEAQAHEIVSGTEKQLEIANLTLEMLRSDGMKMSEACNSLTTELEQSKSEVRSLEQLVRQLEEEDEARGNANGDSSSVEELKEEINVARQEISQLKSAVEVTERRYHEEYIQSTLQIRTAYEQVDEVKSGYAQREAELGEELKKTKAERDSLHERLMDKEAKLRILVDENEILNSKIKEKEEVYLNLENSLNQNEPEDTGELKKLESDVMELRANLMDKEMELQSVMSQYESLRSEMETMQSEKNKAIDEALAKLGSLTEEADKSGKRAENATEQLGAAQVTNTELEAELRRLKVQCDQWRKAAEAAATMLSGGNNNNNSNGKYVERTGSLESPLRRRNVNMSPYMGETDDELSSPKKKNGSMLKKIGVLLKKSQK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Phosphorylation	LEVPQKKSPASTPKT CCCCCCCCCCCCCHH	32.50	25561503
21	Phosphorylation	PQKKSPASTPKTARK CCCCCCCCCCHHHHH	48.94	25561503
22	Phosphorylation	QKKSPASTPKTARKL CCCCCCCCCHHHHHC	30.80	25561503
25	Phosphorylation	SPASTPKTARKLKTS CCCCCCHHHHHCCCC	32.66	25561503
38	Phosphorylation	TSESDPVSSPNTKIR CCCCCCCCCCCCCCC	45.53	23776212
39	Phosphorylation	SESDPVSSPNTKIRT CCCCCCCCCCCCCCC	23.54	23776212
60	Phosphorylation	KVVADRRSPRTPVNE CCCCCCCCCCCCHHH	21.45	23111157
63	Phosphorylation	ADRRSPRTPVNEIQK CCCCCCCCCHHHHHH	34.67	23111157
535	Phosphorylation	NGKYVERTGSLESPL CCCCCCCCCCCCCCH	20.02	23776212
537	Phosphorylation	KYVERTGSLESPLRR CCCCCCCCCCCCHHH	28.49	23776212
540	Phosphorylation	ERTGSLESPLRRRNV CCCCCCCCCHHHCCC	34.23	30291188
550	Phosphorylation	RRRNVNMSPYMGETD HHCCCCCCCCCCCCC	14.00	23776212
552	Phosphorylation	RNVNMSPYMGETDDE CCCCCCCCCCCCCCC	15.50	23776212
556	Phosphorylation	MSPYMGETDDELSSP CCCCCCCCCCCCCCC	42.92	23776212
561	Phosphorylation	GETDDELSSPKKKNG CCCCCCCCCCCCCCC	42.41	23776212
562	Phosphorylation	ETDDELSSPKKKNGS CCCCCCCCCCCCCCH	54.05	23776212

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ICR2_ARATH !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ICR2_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ICR2_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of ICR2_ARATH !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ICR2_ARATH

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale Arabidopsis phosphoproteome profiling reveals novelchloroplast kinase substrates and phosphorylation networks."; Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,Grossmann J., Gruissem W., Baginsky S.; Plant Physiol. 150:889-903(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-540, AND MASSSPECTROMETRY.	19376835 [Abstract]