dbPTM

ICDHC_ARATH - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ICDHC_ARATH
UniProt AC	Q9SRZ6
Protein Name	Cytosolic isocitrate dehydrogenase [NADP]
Gene Name	CICDH
Organism	Arabidopsis thaliana (Mouse-ear cress).
Sequence Length	410
Subcellular Localization	Cytoplasm, cytosol.
Protein Description	May supply 2-oxoglutarate for amino acid biosynthesis and ammonia assimilation via the glutamine synthetase/glutamate synthase (GS/GOGAT) pathway. May be involved in the production of NADPH to promote redox signaling or homeostasis in response to oxidative stress..
Protein Sequence	MAFEKIKVANPIVEMDGDEMTRVIWKSIKDKLITPFVELDIKYFDLGLPHRDATDDKVTIESAEATKKYNVAIKCATITPDEGRVTEFGLKQMWRSPNGTIRNILNGTVFREPIICKNVPKLVPGWTKPICIGRHAFGDQYRATDAVIKGPGKLTMTFEGKDGKTETEVFTFTGEGGVAMAMYNTDESIRAFADASMNTAYEKKWPLYLSTKNTILKKYDGRFKDIFQEVYEASWKSKYDAAGIWYEHRLIDDMVAYALKSEGGYVWACKNYDGDVQSDFLAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHFRVHQKGGETSTNSIASIFAWTRGLAHRAKLDDNAKLLDFTEKLEAACVGTVESGKMTKDLALIIHGSKLSRDTYLNTEEFIDAVAAELKERLNA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	Reference
15	Sulfoxidation	VANPIVEMDGDEMTR CCCCEEEECHHHHHH	23289948
20	Sulfoxidation	VEMDGDEMTRVIWKS EEECHHHHHHHHHHH	23289948
34	Phosphorylation	SIKDKLITPFVELDI HHHHCCCCCEEEEEE	19880383
127	Phosphorylation	PKLVPGWTKPICIGR CCCCCCCCCCEEEEC	22092075
156	Sulfoxidation	KGPGKLTMTFEGKDG ECCCEEEEEEECCCC	25693801
211	Phosphorylation	KWPLYLSTKNTILKK CCCEEEECCCCHHHH	22438062

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ICDHC_ARATH !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ICDHC_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ICDHC_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of ICDHC_ARATH !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ICDHC_ARATH

Related Literatures of Post-Translational Modification