ICAM5_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ICAM5_MOUSE
• UniProt AC: Q60625
• Protein Name: Intercellular adhesion molecule 5
• Gene Name: Icam5
• Organism: Mus musculus (Mouse).
• Sequence Length: 917
• Subcellular Localization: Membrane ; Single-pass type I membrane protein .
• Protein Description: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2)..
• Protein Sequence: MPGPSPGLRRALLGLWAALGLGILGISAVALEPFWADLQPRVALVERGGSLWLNCSTNCPRPERGGLETSLRRNGTQRGLRWLARQLVDIREPETQPVCFFRCARRTLQARGLIRTFQRPDRVELVPLPSWQPVGENFTLSCRVPGAGPRASLTLTLLRGGQELIRRSFVGEPPRARGAMLTARVLARREDHRVNFSCLAELDLRPHGLGLFANSSAPRQLRTFAMPPHSPSLIAPRVLEVDSERPVTCTLDGLFPAPEAGVYLSLGDQRLNPNVTLDGDSLVATATATASAEQEGTKQLMCVVTLGGESRETQENLTVYSFPTPLLTLSEPEAPEGKMVTISCWAGARALVTLEGIPAAVPGQPAELQLNVTKNDDKRGFFCDAALDVDGETLRKNQSSELRVLYAPRLDDLDCPRSWTWPEGPEQTLHCEARGNPEPSVHCARPEGGAVLALGLLGPVTRALAGTYRCTAVNGQGQAVKDVTLTVEYAPALDSVGCPEHITWLEGTEASLSCVAHGVPPPSVSCVRSGKEEVMEGPLRVAREHAGTYRCEAINARGSAAKNVAVTVEYGPSFEELGCPSNWTWVEGSGKLFSCEVDGKPEPRVECVGSEGASEGIVLPLVSSNSGPRNSMTPGNLSPGIYLCNATNRHGSTVKTVVVSAESPPQMDESSCPSHQTWLEGAEATALACSARGRPSPRVHCSREGAARLERLQVSREDAGTYRCVATNAHGTDSRTVTVGVEYRPVVAELAASPPSVRPGGNFTLTCRAEAWPPAQISWRAPPGALNLGLSSNNSTLSVAGAMGSHGGEYECAATNAHGRHARRITVRVAGPWLWVAVGGAAGGAALLAAGAGLAFYVQSTACKKGEYNVQEAESSGEAVCLNGAGGTPGAEGGAETPGTAESPADGEVFAIQLTSS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
54	N-linked_Glycosylation	RGGSLWLNCSTNCPR CCCEEEEECCCCCCC	13.20	22187327
74	N-linked_Glycosylation	LETSLRRNGTQRGLR CCHHHHHCCCHHHHH	51.97	-
137	N-linked_Glycosylation	SWQPVGENFTLSCRV CCCCCCCCEEEEEEC	29.31	-
182	Phosphorylation	RARGAMLTARVLARR CHHHHHHHHHHHHCC	10.18	-
195	N-linked_Glycosylation	RREDHRVNFSCLAEL CCCCCCCCEEEEEEC	24.07	-
214	N-linked_Glycosylation	HGLGLFANSSAPRQL CCEEEECCCCCCCCH	29.21	-
274	N-linked_Glycosylation	GDQRLNPNVTLDGDS CCCCCCCCCEECCCE	38.03	-
316	N-linked_Glycosylation	ESRETQENLTVYSFP CCCCCCCCEEEEECC	31.06	-
371	N-linked_Glycosylation	QPAELQLNVTKNDDK CCEEEEEECCCCCCC	26.84	-
397	N-linked_Glycosylation	DGETLRKNQSSELRV CCCHHCCCCCCCCEE	40.30	-
399	Phosphorylation	ETLRKNQSSELRVLY CHHCCCCCCCCEEEE	34.86	24759943
400	Phosphorylation	TLRKNQSSELRVLYA HHCCCCCCCCEEEEC	30.77	24759943
406	Phosphorylation	SSELRVLYAPRLDDL CCCCEEEECCCCCCC	16.23	24759943
582	N-linked_Glycosylation	EELGCPSNWTWVEGS HHHCCCCCCEEEECC	25.91	-
645	N-linked_Glycosylation	SPGIYLCNATNRHGS CCCEEEEECCCCCCC	47.40	-
762	N-linked_Glycosylation	PSVRPGGNFTLTCRA CCCCCCCCEEEEEEE	32.42	-
793	N-linked_Glycosylation	LNLGLSSNNSTLSVA EEECCCCCCCEEEEE	42.99	-
794	N-linked_Glycosylation	NLGLSSNNSTLSVAG EECCCCCCCEEEEEE	38.02	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ICAM5_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
54	N	Glycosylation	Glycosylation at Asn-54 is critical for functional folding.	22187327

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ICAM5_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ICAM5_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.