IBTK_MOUSE - dbPTM
IBTK_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID IBTK_MOUSE
UniProt AC Q6ZPR6
Protein Name Inhibitor of Bruton tyrosine kinase
Gene Name Ibtk
Organism Mus musculus (Mouse).
Sequence Length 1352
Subcellular Localization Cytoplasm. Membrane
Peripheral membrane protein. Translocates to the plasma membrane upon IgM stimulation..
Protein Description Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription (By similarity)..
Protein Sequence MDAATPDCTSKCRSLKHALDVLSVVTKGSESQIKSFLARYCYNAATVKDAFGRNAGHLASSCGKKGVLDWLIEKGVDLLVKDKESGWTALHRSVFYGHIDCVWSLLKHGVSLYMQDKEGLSPLDLLMKDRPTHVVFKDTDPTEVYTWGDNTNFTLGHGSQNSKHHPELLDLFSRSGVYVKQVVLCKFHSVFLSQKGQVYTCGHGRGGRLGHGDEQTCLVPRLVEGLSGHNCSQVAAAKDHTVVLTDDGCVYTFGLNMFHQLGIIPPPASCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWTREAVYTLGLNGGQLGHLLDPNGEKCVTTPRQVSALHHKDIAVSLVAASDGATVCVTTRGDIYLLADYQCKKMATKQLNLKKVLVSGGCMEYKVDPEHLTENGGQKICVLAMDGAGRVFCWRSISSSLKQCRWAYPRQVSISDIALNRNEILFVTQDGEGFKGKWFEDKRKNSEKKADILPNLHHSSSDVSCVPDTNSVYERIRLEKLPFAHRAVSVSTDPSGCNFAILQSDPKTSLYEIPVVSSSSFFEEFGKLLRETDEMDSFHDVTFQVGNRHFPAHKYILAVRSDFFQKLFLSDGSSLELTDVYQKDEDAAGCHLFVVEKVHPDLFEYLLQFMYTDTCDLLTHGFKPRMIVKRKAEDCEGSPDSHLHTVNCHVDDKQKSAFEVYRSNQAHTLSERQKSKPKSSKKGKGVGDDDPVRMLQSVAKKFGLSNLSSRLEGVRLENEKINVIAKKTGNKLKLSQKKCSFLYDVTMKSVDGKEFSCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQSEILKVILDYLYTDEAVVIKESQNVDFVCSVLVVADQLLITRLKEICEVALTENLTLKNAAMLLEFAALYNAGQLKLSCLQFIGLNMAALLEARSLDVLSEDVLKDLSIFYRKMIPAMERRVITPYQDGPDISSMQVEDGEVFFKEEINMEPNYSETMFKKAKTRAKKKPRKRSDSSGGYTLSDVIQSPPSAGLLKSAKTNSVESLPELLTSDSEGSYAGVASPRDLQSPDFTAGFHSDKVEGKAKPYVNGIPPPCTREDVKPWEKSPTTKSAPQFIPSNRVDTAASSSWLAGSCSPVSPPVVDLRTIMETEENRQKYGAAPKSNLGKIISHGIKLSQKQRKMIALTTKENNSGTNSMEAILTAPSKSPKPANAWAPLHSPLSRSFRDFLLEEKKPVPGYGSGDHVKKVCFKGTENSPALNVARCSTHGTPGLESNHVSDFPLLDSPNPWQSSSLAASPAVAPVTFASIVEEERQQEAALIRSREKPLALIQVEEHAIQDLLVFYEAFGNPEEFVVVERAPQGPLAVPMWNKHGC
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
35PhosphorylationGSESQIKSFLARYCY
CCHHHHHHHHHHHHH		27.4124719451
61PhosphorylationNAGHLASSCGKKGVL
CHHHHHHHHCCCCHH		22.6828285833
178PhosphorylationLFSRSGVYVKQVVLC
HHHCCCCCEEEEEEE		12.8820139300
285PhosphorylationAKYLKGRTIIGVAAG
HHHCCCCEEEEEEEC		26.1422871156
300PhosphorylationRFHTVLWTREAVYTL
CCEEEEEECCEEEEE		17.9222871156
424PhosphorylationVFCWRSISSSLKQCR
EEEHHHHCHHHHHCC		18.3422942356
425PhosphorylationFCWRSISSSLKQCRW
EEHHHHCHHHHHCCC		37.71-
426PhosphorylationCWRSISSSLKQCRWA
EHHHHCHHHHHCCCC		32.56-
461UbiquitinationTQDGEGFKGKWFEDK
EECCCCCCCCCCCCH		71.1322790023
664PhosphorylationKAEDCEGSPDSHLHT
ECHHCCCCCCCCCEE		11.8425159016
667PhosphorylationDCEGSPDSHLHTVNC
HCCCCCCCCCEEEEE		31.1925777480
671PhosphorylationSPDSHLHTVNCHVDD
CCCCCCEEEEEECCC		21.5525777480
731PhosphorylationVAKKFGLSNLSSRLE
HHHHHCCCCHHHHHH		35.7822817900
930UbiquitinationDLSIFYRKMIPAMER
HHHHHHHHHHHHHHC		29.7822790023
991PhosphorylationKKKPRKRSDSSGGYT
CCCCCCCCCCCCCCC		44.9027087446
993PhosphorylationKPRKRSDSSGGYTLS
CCCCCCCCCCCCCHH		31.9321082442
994PhosphorylationPRKRSDSSGGYTLSD
CCCCCCCCCCCCHHH		41.0227087446
997PhosphorylationRSDSSGGYTLSDVIQ
CCCCCCCCCHHHHHC		14.1825521595
998PhosphorylationSDSSGGYTLSDVIQS
CCCCCCCCHHHHHCC		24.0625168779
1000PhosphorylationSSGGYTLSDVIQSPP
CCCCCCHHHHHCCCC		23.2528833060
1005PhosphorylationTLSDVIQSPPSAGLL
CHHHHHCCCCCCCCH		27.8821082442
1008PhosphorylationDVIQSPPSAGLLKSA
HHHCCCCCCCCHHCC		38.0521082442
1017PhosphorylationGLLKSAKTNSVESLP
CCHHCCCCCCCCCHH		32.2325293948
1019PhosphorylationLKSAKTNSVESLPEL
HHCCCCCCCCCHHHH		32.2825293948
1022PhosphorylationAKTNSVESLPELLTS
CCCCCCCCHHHHHHC		47.2525293948
1028PhosphorylationESLPELLTSDSEGSY
CCHHHHHHCCCCCCC		43.0125293948
1029PhosphorylationSLPELLTSDSEGSYA
CHHHHHHCCCCCCCC		38.8225293948
1031PhosphorylationPELLTSDSEGSYAGV
HHHHHCCCCCCCCCC		43.5625293948
1034PhosphorylationLTSDSEGSYAGVASP
HHCCCCCCCCCCCCC		14.0425293948
1035PhosphorylationTSDSEGSYAGVASPR
HCCCCCCCCCCCCCC		20.4525293948
1040PhosphorylationGSYAGVASPRDLQSP
CCCCCCCCCCCCCCC		20.3325293948
1046PhosphorylationASPRDLQSPDFTAGF
CCCCCCCCCCCCCCC		33.4627087446
1050PhosphorylationDLQSPDFTAGFHSDK
CCCCCCCCCCCCCCC		33.0027742792
1055PhosphorylationDFTAGFHSDKVEGKA
CCCCCCCCCCCCCCC		36.5425619855
1084PhosphorylationDVKPWEKSPTTKSAP
HCCCCCCCCCCCCCC		18.9026824392
1086PhosphorylationKPWEKSPTTKSAPQF
CCCCCCCCCCCCCCC		54.6825159016
1087PhosphorylationPWEKSPTTKSAPQFI
CCCCCCCCCCCCCCC		26.7925159016
1101PhosphorylationIPSNRVDTAASSSWL
CCCCCCCCCCCCCHH		22.6725293948
1104PhosphorylationNRVDTAASSSWLAGS
CCCCCCCCCCHHCCC		23.5725293948
1105PhosphorylationRVDTAASSSWLAGSC
CCCCCCCCCHHCCCC		22.3225293948
1106PhosphorylationVDTAASSSWLAGSCS
CCCCCCCCHHCCCCC		24.5025293948
1111PhosphorylationSSSWLAGSCSPVSPP
CCCHHCCCCCCCCCC		13.0521659605
1113PhosphorylationSWLAGSCSPVSPPVV
CHHCCCCCCCCCCEE		29.9921659605
1116PhosphorylationAGSCSPVSPPVVDLR
CCCCCCCCCCEECHH		27.2026745281
1135PhosphorylationTEENRQKYGAAPKSN
CHHHHHHHCCCCCCH		12.03-
1141PhosphorylationKYGAAPKSNLGKIIS
HHCCCCCCHHHHHHH		35.9121454597
1154PhosphorylationISHGIKLSQKQRKMI
HHHCCCCCHHHHHEE		30.2621454597
1156AcetylationHGIKLSQKQRKMIAL
HCCCCCHHHHHEEEE		49.016567399
1170PhosphorylationLTTKENNSGTNSMEA
EEECCCCCCCCCCEE		59.5821183079
1174PhosphorylationENNSGTNSMEAILTA
CCCCCCCCCEEHEEC		20.1721183079
1180PhosphorylationNSMEAILTAPSKSPK
CCCEEHEECCCCCCC		30.3421183079
1185PhosphorylationILTAPSKSPKPANAW
HEECCCCCCCCCCCC		42.3629233185
1197PhosphorylationNAWAPLHSPLSRSFR
CCCCCCCCCCCHHHH		34.9130352176
1200PhosphorylationAPLHSPLSRSFRDFL
CCCCCCCCHHHHHHH		29.3025266776
1202PhosphorylationLHSPLSRSFRDFLLE
CCCCCCHHHHHHHHH		22.6624899341
1219PhosphorylationKPVPGYGSGDHVKKV
CCCCCCCCCCCCEEE		32.3428066266
1234PhosphorylationCFKGTENSPALNVAR
EEECCCCCCCHHEEE		12.8128066266
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of IBTK_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of IBTK_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of IBTK_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of IBTK_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of IBTK_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"The phagosomal proteome in interferon-gamma-activated macrophages.";
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.;
Immunity 30:143-154(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1046, AND MASSSPECTROMETRY.
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1046, AND MASSSPECTROMETRY.
"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-998, AND MASSSPECTROMETRY.

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