IBP4_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IBP4_RAT
• UniProt AC: P21744
• Protein Name: Insulin-like growth factor-binding protein 4
• Gene Name: Igfbp4
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 254
• Subcellular Localization: Secreted.
• Protein Description: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors..
• Protein Sequence: MLPFGLVAALLLAAGPRPSLGDEAIHCPPCSEEKLARCRPPVGCEELVREPGCGCCATCALGLGMPCGVYTPRCGSGMRCYPPRGVEKPLRTLMHGQGVCTELSEIEAIQESLQTSDKDESEHPNNSFNPCSAHDHRCLQKHMAKVRDRSKMKVVGTPREEPRPVPQGSCQSELHRALERLAASQSRTHEDLFIIPIPNCDRNGNFHPKQCHPALDGQRGKCWCVDRKTGVKLPGGLEPKGELDCHQLADSLQE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
125	N-linked_Glycosylation	KDESEHPNNSFNPCS CCCCCCCCCCCCCCH	59.70	-
251	Phosphorylation	DCHQLADSLQE---- CHHHHHHHHCC----	26.75	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IBP4_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IBP4_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IBP4_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of IBP4_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.