dbPTM

IAPP_RAT - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	IAPP_RAT
UniProt AC	P12969
Protein Name	Islet amyloid polypeptide
Gene Name	Iapp
Organism	Rattus norvegicus (Rat).
Sequence Length	93
Subcellular Localization	Secreted.
Protein Description	Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism..
Protein Sequence	MRCISRLPAVLLILSVALGHLRATPVGSGTNPQVDKRKCNTATCATQRLANFLVRSSNNLGPVLPPTNVGSNTYGKRNVAEDPNRESLDFLLL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
74	Tyrosine amide	TNVGSNTYGKRNVAE CCCCCCCCCCCCCCC	25.54	-
74	Amidation	TNVGSNTYGKRNVAE CCCCCCCCCCCCCCC	25.54	2679555

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of IAPP_RAT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of IAPP_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of IAPP_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of IAPP_RAT !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of IAPP_RAT

Related Literatures of Post-Translational Modification

Amidation
Reference	PubMed
"Isolation and sequence determination of rat islet amyloidpolypeptide."; Asai J., Nakazato M., Kangawa K., Matsukura S., Matsuo H.; Biochem. Biophys. Res. Commun. 164:400-405(1989). Cited for: PROTEIN SEQUENCE OF 38-74.	2679555 [Abstract]