I2BP1_MOUSE - dbPTM
I2BP1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID I2BP1_MOUSE
UniProt AC Q8R3Y8
Protein Name Interferon regulatory factor 2-binding protein 1
Gene Name Irf2bp1
Organism Mus musculus (Mouse).
Sequence Length 584
Subcellular Localization Nucleus .
Protein Description Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities. May act as an E3 ligase towards JDP2, enhancing its polyubiquitination. Represses ATF2-dependent transcriptional activation..
Protein Sequence MASVQASRRQWCYLCDLPKMPWAMVWDFSEAVCRGCVNFEGADRIELLIDAARQLKRSHVLPEGRSPGPPALKHPTSKDLASTGSQGSQLPPPQAQAQPSGTGGSVSGPDRYDRATSSSRLALPSPALEYTLGSRLANGLGREEAVAEGARRALLGSIPSLMPPGLLAAAVSGLGGRALTLAPGLSPARPLFGSDFEKEKQQRNADCLAELNEAMRGRAEEWHGRPKAVREQLLALSACAPFNVRFKKDHGLVGRVFAFDATARPPGYEFELKLFTEYPCGSGNVYAGVLAVARQMFHDALREPGKALASSGFKYLEYERRHGSGEWRQLGELLTDGVRSFREPAPAEALPQQYPEPAPAALCGPPPRAPSRNLAPTPRRRKASPEPEGETAGKMTTEEQQQRHWVAPGGPYSSETPGVPSPIAALKNVAEALGHSPKDPGGGGGSVRAGGASPAASSTTQPPAQHRLVARNGEAEVSPTAGAEAVSGGGSGTGATPGAPLCCTLCRERLEDTHFVQCPSVPGHKFCFPCSREFIKAQGPAGEVYCPSGDKCPLVGSSVPWAFMQGEIATILAGDIKVKKERDP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
66PhosphorylationHVLPEGRSPGPPALK
CCCCCCCCCCCCCCC		45.1025521595
125PhosphorylationSSRLALPSPALEYTL
CCCCCCCCHHHHHHH		24.5326239621
130PhosphorylationLPSPALEYTLGSRLA
CCCHHHHHHHHHHHH		14.2328066266
177MethylationAVSGLGGRALTLAPG
HHHCCCCCHHHCCCC		25.32-
180PhosphorylationGLGGRALTLAPGLSP
CCCCCHHHCCCCCCC		21.6427600695
186PhosphorylationLTLAPGLSPARPLFG
HHCCCCCCCCCCCCC		23.5626824392
194PhosphorylationPARPLFGSDFEKEKQ
CCCCCCCCHHHHHHH		31.6227717184
314UbiquitinationALASSGFKYLEYERR
HHHHCCCCEEEEEHH		53.0722790023
354PhosphorylationAEALPQQYPEPAPAA
HHHCCCCCCCCCCHH		12.3324759943
371PhosphorylationGPPPRAPSRNLAPTP
CCCCCCCCCCCCCCC		32.5824453211
377PhosphorylationPSRNLAPTPRRRKAS
CCCCCCCCCCCCCCC		24.6624453211
384PhosphorylationTPRRRKASPEPEGET
CCCCCCCCCCCCCCC		32.6027087446
391PhosphorylationSPEPEGETAGKMTTE
CCCCCCCCCCCCCHH		52.1228833060
413PhosphorylationVAPGGPYSSETPGVP
CCCCCCCCCCCCCCC		25.4929472430
414PhosphorylationAPGGPYSSETPGVPS
CCCCCCCCCCCCCCC		39.3829472430
416PhosphorylationGGPYSSETPGVPSPI
CCCCCCCCCCCCCHH		27.5629514104
421PhosphorylationSETPGVPSPIAALKN
CCCCCCCCHHHHHHH		26.9125521595
436PhosphorylationVAEALGHSPKDPGGG
HHHHHCCCCCCCCCC		31.6727087446
446PhosphorylationDPGGGGGSVRAGGAS
CCCCCCCCCCCCCCC		16.2325619855
453PhosphorylationSVRAGGASPAASSTT
CCCCCCCCCCCCCCC		20.5327087446
457PhosphorylationGGASPAASSTTQPPA
CCCCCCCCCCCCCCH		30.2623984901
458PhosphorylationGASPAASSTTQPPAQ
CCCCCCCCCCCCCHH		30.6525619855
459PhosphorylationASPAASSTTQPPAQH
CCCCCCCCCCCCHHH		27.2725619855
460PhosphorylationSPAASSTTQPPAQHR
CCCCCCCCCCCHHHC		40.8125619855
478PhosphorylationRNGEAEVSPTAGAEA
ECCEEEECCCCCCCC		14.1924453211
480PhosphorylationGEAEVSPTAGAEAVS
CEEEECCCCCCCCCC		30.1621183079
487PhosphorylationTAGAEAVSGGGSGTG
CCCCCCCCCCCCCCC		38.4823984901
491PhosphorylationEAVSGGGSGTGATPG
CCCCCCCCCCCCCCC		36.1323984901
493PhosphorylationVSGGGSGTGATPGAP
CCCCCCCCCCCCCCC		25.9123984901
496PhosphorylationGGSGTGATPGAPLCC
CCCCCCCCCCCCCEE		24.4923984901
504PhosphorylationPGAPLCCTLCRERLE
CCCCCEEHHHHHHHC		28.0925777480
548PhosphorylationAGEVYCPSGDKCPLV
CCEEECCCCCCCCCC		56.9429899451
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of I2BP1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of I2BP1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of I2BP1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of I2BP1_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of I2BP1_MOUSE

loading...

Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large scale localization of protein phosphorylation by use ofelectron capture dissociation mass spectrometry.";
Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.;
Mol. Cell. Proteomics 8:904-912(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-453, AND MASSSPECTROMETRY.
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-384; SER-436 ANDSER-453, AND MASS SPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory