HXK1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HXK1_RAT
• UniProt AC: P05708
• Protein Name: Hexokinase-1
• Gene Name: Hk1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 918
• Subcellular Localization: Mitochondrion outer membrane. Its hydrophobic N-terminal sequence may be involved in membrane binding.
• Protein Sequence: MIAAQLLAYYFTELKDDQVKKIDKYLYAMRLSDEILIDILTRFKKEMKNGLSRDYNPTASVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQNVSMESEIYDTPENIVHGSGTQLFDHVADCLGDFMEKKKIKDKKLPVGFTFSFPCRQSKIDEAVLITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQQCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDRELDRGSLNPGKQLFEKMVSGMYMGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVSAIEKDKEGIQNAKEILTRLGVEPSDVDCVSVQHICTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKMHPQYSRRFHKTLRRLVPDSDVRFLLSESGTGKGAAMVTAVAYRLAEQHRQIEETLAHFRLSKQTLMEVKKRLRTEMEMGLRKETNSKATVKMLPSFVRSIPDGTEHGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYSIPLEIMQGTGDELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCHQTNLDCGILISWTKGFKATDCEGHDVASLLRDAVKRREEFDLDVVAVVNDTVGTMMTCAYEEPTCEIGLIVGTGTNACYMEEMKNVEMVEGNQGQMCINMEWGAFGDNGCLDDIRTDFDKVVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISEPLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSKRAAQLCGAGMAAVVEKIRENRGLDHLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCTVSFLLSEDGSGKGAALITAVGVRLRGDPSIA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MIAAQLLA -------CHHHHHHH	4.19	-
21	Acetylation	LKDDQVKKIDKYLYA CCHHHHHHHHHHHHH	58.23	22902405
24	Acetylation	DQVKKIDKYLYAMRL HHHHHHHHHHHHHHC	40.40	22902405
25	Phosphorylation	QVKKIDKYLYAMRLS HHHHHHHHHHHHHCC	10.95	-
27	Phosphorylation	KKIDKYLYAMRLSDE HHHHHHHHHHHCCHH	8.68	-
62	Ubiquitination	YNPTASVKMLPTFVR CCCCCHHCCCCEEHH	32.02	-
62	Acetylation	YNPTASVKMLPTFVR CCCCCHHCCCCEEHH	32.02	22902405
77	Acetylation	SIPDGSEKGDFIALD CCCCCCCCCCEEEEE	66.53	22902405
88	Phosphorylation	IALDLGGSSFRILRV EEEECCCCCEEEEEE	25.22	22673903
89	Phosphorylation	ALDLGGSSFRILRVQ EEECCCCCEEEEEEE	23.09	22673903
176	Acetylation	ITWTKRFKASGVEGA EEECCCCHHCCCCCH	45.75	22902405
187	Ubiquitination	VEGADVVKLLNKAIK CCCHHHHHHHHHHHH	47.29	-
187	Acetylation	VEGADVVKLLNKAIK CCCHHHHHHHHHHHH	47.29	22902405
191	Ubiquitination	DVVKLLNKAIKKRGD HHHHHHHHHHHHCCC	52.00	-
191	Acetylation	DVVKLLNKAIKKRGD HHHHHHHHHHHHCCC	52.00	22902405
269	Phosphorylation	GAFGDDGSLEDIRTE CCCCCCCCHHHHHHH	35.26	22673903
312	Acetylation	LVRLILVKMAKEGLL HHHHHHHHHHHCCCC	29.69	22902405
333	Acetylation	PELLTRGKFNTSDVS HHHHHCCCCCHHHCH	31.95	22902405
333	Ubiquitination	PELLTRGKFNTSDVS HHHHHCCCCCHHHCH	31.95	-
336	Phosphorylation	LTRGKFNTSDVSAIE HHCCCCCHHHCHHHH	29.45	23991683
337	Phosphorylation	TRGKFNTSDVSAIEK HCCCCCHHHCHHHHH	36.80	23991683
344	Acetylation	SDVSAIEKDKEGIQN HHCHHHHHCHHHHHH	68.90	22902405
346	Acetylation	VSAIEKDKEGIQNAK CHHHHHCHHHHHHHH	69.75	22902405
353	Acetylation	KEGIQNAKEILTRLG HHHHHHHHHHHHHHC	53.49	22902405
415	Phosphorylation	TTVGVDGSLYKMHPQ EEECCCCCHHCCCHH	24.86	25403869
418	Acetylation	GVDGSLYKMHPQYSR CCCCCHHCCCHHHHH	35.71	22902405
429	Acetylation	QYSRRFHKTLRRLVP HHHHHHHHHHHHHCC	46.68	25786129
461	Phosphorylation	AMVTAVAYRLAEQHR HHHHHHHHHHHHHHH	10.28	18331841
480	Phosphorylation	TLAHFRLSKQTLMEV HHHHHHCCHHHHHHH	20.61	25403869
481	Acetylation	LAHFRLSKQTLMEVK HHHHHCCHHHHHHHH	52.47	22902405
488	Ubiquitination	KQTLMEVKKRLRTEM HHHHHHHHHHHHHHH	20.90	-
510	Ubiquitination	TNSKATVKMLPSFVR CCCHHHHHCCHHHHH	30.30	-
544	Acetylation	NFRVLLVKIRSGKKR EEEEEEEEECCCCCE	32.16	30595241
635	Phosphorylation	CEGHDVASLLRDAVK CCCCCHHHHHHHHHH	27.99	25403869
749	Phosphorylation	EKMISGMYLGEIVRN HHHHHHHHHHHHHHH	18.32	-
763	Ubiquitination	NILIDFTKKGFLFRG HHHHHHHCCCEEECE	51.39	-
763	Acetylation	NILIDFTKKGFLFRG HHHHHHHCCCEEECE	51.39	22902405
764	Acetylation	ILIDFTKKGFLFRGQ HHHHHHCCCEEECEE	52.41	22902405
777	Acetylation	GQISEPLKTRGIFET EECCCCCCCCCCEEH	47.06	22902405
880	Acetylation	RIMHQTVKELSPKCT HHHHHHHHHHCCCCE	57.22	22902405

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HXK1_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HXK1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HXK1_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of HXK1_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.