HXD11_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HXD11_HUMAN
• UniProt AC: P31277
• Protein Name: Homeobox protein Hox-D11
• Gene Name: HOXD11
• Organism: Homo sapiens (Human).
• Sequence Length: 338
• Subcellular Localization: Nucleus.
• Protein Description: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis..
• Protein Sequence: MNDFDECGQSAASMYLPGCAYYVAPSDFASKPSFLSQPSSCQMTFPYSSNLAPHVQPVREVAFRDYGLERAKWPYRGGGGGGSAGGGSSGGGPGGGGGGAGGYAPYYAAAAAAAAAAAAAEEAAMQRELLPPAGRRPDVLFKAPEPVCAAPGPPHGPAGAASNFYSAVGRNGILPQGFDQFYEAAPGPPFAGPQPPPPPAPPQPEGAADKGDPRTGAGGGGGSPCTKATPGSEPKGAAEGSGGDGEGPPGEAGAEKSSSAVAPQRSRKKRCPYTKYQIRELEREFFFNVYINKEKRLQLSRMLNLTDRQVKIWFQNRRMKEKKLNRDRLQYFTGNPLF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
76	Methylation	ERAKWPYRGGGGGGS HHCCCCCCCCCCCCC	32.95	115479633
83	Phosphorylation	RGGGGGGSAGGGSSG CCCCCCCCCCCCCCC	27.32	30278072
215	Phosphorylation	ADKGDPRTGAGGGGG CCCCCCCCCCCCCCC	36.45	27174698
223	Phosphorylation	GAGGGGGSPCTKATP CCCCCCCCCCCCCCC	21.78	30576142
226	Phosphorylation	GGGGSPCTKATPGSE CCCCCCCCCCCCCCC	27.39	27174698
229	Phosphorylation	GSPCTKATPGSEPKG CCCCCCCCCCCCCCC	29.73	21712546
232	Phosphorylation	CTKATPGSEPKGAAE CCCCCCCCCCCCCCC	52.51	29083192
241	Phosphorylation	PKGAAEGSGGDGEGP CCCCCCCCCCCCCCC	30.98	30175587
256	Ubiquitination	PGEAGAEKSSSAVAP CCHHCCCCCCCCCCC	55.92	-
306	Phosphorylation	LSRMLNLTDRQVKIW HHHHHCCCHHHHHHH	28.23	18767875

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HXD11_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HXD11_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HXD11_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of HXD11_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.